Akut intraserebral hemorajide platelet-albumin-bilirubin ve sistemik immun inflamatuar indekslerin değerlendirilmesi

Year 2022, Volume: 1 Issue: 3, 142 - 151, 23.12.2022

Aslı Bolayır , Hasan Ata Bolayır , Şeyda Figül Gökçe , Burhanettin Çiğdem , Sibel Çıplak

Abstract

Amaç: Biz bu çalışmada intraserebral hemoraji (İSH) hastalarında yeni inflamatuar göstergeler olan sistemik immun-inflamatuar indeks (Sİİ) ile platelet-albumin-bilirübin indeksi (PALBİ) ölçmeyi ve bu değerlerin hastalıkla ilişkisi ile İSH’nin kısa dönem prognozu üzerindeki etkisini ortaya koymayı hedefledik.

Materyal ve Metod: Retrospektif çalışmamıza İSH tanısı almış 245 hasta ile 250 sağlıklı gönüllü dahil edildi.

Bulgular: Sağlıklı gönüllülerle karşılaştırıldığında, İSH hastaları daha düşük PALBİ (p=0.028) ve daha yüksek Sİİ değerlerine (p<0.01) sahipti. Ayrıca mRS (modifiye Rankin skalası) ve NIHSS (National Institutes of Health Stroke Scale)'ye göre hem yatışta hem de 30 gün sonunda prognozu kötü ve şiddetli İSH olan hasta grubunda Sİİ oranı daha yüksek iken, PALBİ oranı daha düşüktü. 245 İSH hastasının 45'i 30 gün içinde ex olmuştu. Benzer şekilde, exitus olan grupta Sİİ değeri, hayatta kalan gruba göre istatistiksel olarak anlamlı derecede yüksek (p<0.01), PALBİ değeri ise daha düşüktü (p<0.01). Çok değişkenli lojistik regresyon analizi, başvuru sırasındaki Sİİ ve PALBİ değerlerinin İSH'den sonraki 30 gün içinde mortalitenin bağımsız öngörücüleri olduğunu ortaya koydu. Alıcı çalışma karakteristik eğrileri, Sİİ değeri için 1098.12'nin ve PALBİ değeri için -4.11'in İSH sonrası 30 günlük mortaliteyi tahmin etmek için optimal eşik değerler olduğunu gösterdi.

Sonuç: İSH hastalarında erken dönemde bakılan Sİİ ve PALBİ indeksleri, İSH hastalarının hem akut dönemde hem de 30 günlük ciddiyeti ve prognozu ile yakından ilişkilidir. Ayrıca, İSH sonrası 30 günlük mortaliteyi tahmin etmek için bağımsız öngörücü belirteçler olarak da kullanılabilirler.

Keywords

akut intraserebral kanama, platelet-albümin-bilirubin indeksi, sistemik immün-inflamasyon indeksi, inflamasyon, 30 günlük mortalite

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Project Number

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Thanks

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Evaluation of platelet-albumin-bilirubin (PALBI) and systemic immune-inflammation (SII) indices in acute intracerebral hemorrhage

Abstract

Background: We aimed to evaluate systemic immune-inflammation (SII) and platelet-albumin-bilirubin indices (PALBI), which are new inflammatory markers, in intracerebral hemorrhage (ICH) patients and reveal the relationship of these values with the disease and their effect on the short-term prognosis of ICH.

Materials and Methods: Our retrospective study included 245 patients who were diagnosed with ICH and 250 healthy volunteers.

Results: Compared to healthy volunteers, ICH patients had lower PALBI (p=0.028) and higher SII values (p<0.01). Additionlly while SII rate were higher, PALBI rate were lower in patient group with poor prognosis and severe ICH according to mRS (modified Rankin scale) and NIHSS (National Institutes of Health Stroke Scale) both at admission and at the end of 30 days. 45 of 245 patients died within 30 days. Similarly, the SII value in the group who died was statistically significantly higher than the survived group (p<0.01), while PALBI value was lower (p<0.01). Multivariate logistic regression analysis revealed that SII and PALBI values at admission were independent predictors of mortality within 30 days after ICH. Receiver operating characteristic curves showed that 1098.12 for the SII value and -4.11 for the PALBI value were optimal cut-off values to predict 30-day mortality after ICH.

Conclusions: The SII and PALBI indices, checked in early period in ICH patients, are closely related to the severity and prognosis of ICH patients both in the acute period and at the end of 30 days. Furthermore, they can be used as independent predictive markers to estimate 30-day mortality after ICH.

Keywords

acute intracerebral hemorrhage, platelet-albumin-bilirubin index, systemic immune-inflammation index, inflammation, 30- day mortality

Project Number

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