Research Article
BibTex RIS Cite

Son 10 yıldaki akciğer kanseri insidansındaki eğilimler: Doğu Anadolu'da tek merkez deneyimi

Year 2020, Volume: 4 Issue: 2, 112 - 115, 01.02.2020
https://doi.org/10.28982/josam.683464

Abstract

Amaç: Akciğer kanseri kadın ve erkeklerde kansere bağlı ölümlerin en sık nedeni olup farklı histolojik gruplara göre mortalite ve morbidite oranı değişkenlik göstermektedir. Bu nedenle histolojik tip tayini son derece önemlidir. Çalışmamızın amacı, 2015 Dünya Sağlık Örgütü (DSÖ) Akciğer tümörlerinin güncellenmesinde yapılan değişiklikleri temel alarak Doğu Anadolu Bölgesindeki en büyük merkezlerden birisinde son 10 yılda akciğer kanseri tanısı almış vakaların histolojik alt tiplerini ve aynı zamanda bu histolojik alt tiplerin yıl, cinsiyet ve yaş dağılımı arasındaki ilişkisini incelemektir.
Yöntemler: Kesitsel tipteki bu çalışmada, Ocak 2010-Aralık 2019 yılları arasında merkezimizde akciğer biyopsi materyali olarak gönderilmiş ve akciğer karsinomu tanılı olgular retrospektif olarak incelenmiştir.
Bulgular: Çalışmamızda akciğer kanseri sıklığı yıllara göre artmış olup histolojik tipler benzer oranda artmıştır. En fazla görülen akciğer kanseri tipi kadın ve erkelerin toplamında sırasıyla Skuamöz Hücreli Karsinom (SHK), Küçük Hücreli Akciğer Karsinomu (KHAK) ve Adenokarsinomdur. Kadınlarda en fazla adenokarsinom, erkeklerde ise SHK görülmüş olup istatiksel olarak cinsiyet ile histolojik tip arasında anlamlı bir ilişki izlenmiştir (P<0,001).
Sonuç: Çalışmamızda ülkemizdeki ve gelişmekte olan ülkelerdeki veriler ile benzer şekilde akciğer kanseri sıklığında yıllara göre bir artış izlenmiştir. Gelişmiş ülkelerde adenokarsinom sıklığı artarken SHK sıklığı azalmıştır. Çalışmamızda ise en fazla görülen histolojik tipler benzer oranda artmıştır. Bunun yanı sıra gelişmiş ülkelerle benzer şekilde kadınlarda en fazla görülen akciğer kanseri tipi adenokarsinom olarak bulunmuştur. Tüm popülasyonda ise en sık görülen akciğer kanser tipi değişmemiş olup halen SHK dur. Bu durum erkeklerde sigara içme alışkanlığındaki değişikliklerin olmaması ile ilişkilendirilebilir.

Supporting Institution

yok

Project Number

yok

Thanks

yok

References

  • 1. Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, et al. Cancer treatment and survivorship statistics, 2019. CA: a cancer journal for clinicians. 2019;69(5):363-85.
  • 2. Noone A, Howlader N, Krapcho M, Miller D, Brest A, Yu M, et al. SEER cancer statistics review, 1975-2015. Bethesda, MD: National Cancer Institute. 2018.
  • 3. Latimer K, Mott T. Lung cancer: diagnosis, treatment principles, and screening. American family physician. 2015;91(4):250-6.
  • 4. Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JH, Beasley MB, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. Journal of thoracic oncology. 2015;10(9):1243-60.
  • 5. Goksel T, Akkoclu A. Pattern of lung cancer in Turkey, 1994-1998. Turkish Thoracic Society, Lung and Pleural Malignancies Study Group. Respiration. 2002;69:207-10.
  • 6. Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, et al. The global burden of cancer 2013. JAMA oncology. 2015;1(4):505-27.
  • 7. Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung cancer. Annals of global health. 2019;85(1).
  • 8. Lewis DR, Check DP, Caporaso NE, Travis WD, Devesa SS. US lung cancer trends by histologic type. Cancer. 2014;120(18):2883-92.
  • 9. Goss PE, Strasser-Weippl K, Lee-Bychkovsky BL, Fan L, Li J, Chavarri-Guerra Y, et al. Challenges to effective cancer control in China, India, and Russia. The lancet oncology. 2014;15(5):489-538.
  • 10. Osmani L, Askin F, Gabrielson E, Li QK, editors. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Seminars in cancer biology; 2018: Elsevier.
  • 11. Zheng M. Classification and pathology of lung cancer. Surgical Oncology Clinics. 2016;25(3):447-68.
  • 12. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of thoracic oncology. 2011;6(2):244-85.
  • 13. Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, et al. Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clinical Cancer Research. 2014;20(22):5777-86.
  • 14. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, et al. Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Archives of Pathology and Laboratory Medicine. 2013;137(5):685-705.
  • 15. Myers DJ, Wallen JM. Cancer, Lung Adenocarcinoma. StatPearls (Internet): StatPearls Publishing; 2019.
  • 16. Li C, Lu H. Adenosquamous carcinoma of the lung. OncoTargets and therapy. 2018;11:4829.
  • 17. Youlden DR, Cramb SM, Baade PD. The International Epidemiology of Lung Cancer: geographical distribution and secular trends. Journal of Thoracic Oncology. 2008;3(8):819-31.
  • 18. Bircan HA, Öztürk Ö, Şahin Ü, Özaydın N, Akkaya A. Akciğer kanseri tanısı alan olgularımızın Retrospektif değerlendirilmesi. SDÜ Tıp Fakültesi Dergisi. 2005;12(3):1-6.
  • 19. Yurdakul AS, Çalışır HC, Demirağ F, Taci N, Öğretensoy M. Akciğer kanserinin histolojik tiplerinin dağılımı. Toraks Dergisi. 2002;3(1):59-65.

Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience

Year 2020, Volume: 4 Issue: 2, 112 - 115, 01.02.2020
https://doi.org/10.28982/josam.683464

Abstract

Aim: Lung cancer is the most common cause of cancer-related deaths among men and women, and mortality and morbidity rates vary according to different histological groups. Therefore, histological type determination is extremely important. The purpose of the study is to investigate the histological subtypes of lung cancer cases within the last 10 years in one of the biggest centers of the Eastern Anatolian Region, considering the changes made in the 2015 updates in lung tumors by World Health Organization (WHO), and investigate the relationship between these histological sub-types and distribution according to year, gender and age.
Methods: In this cross-sectional study, patients who were referred for lung biopsy between January 2010 and December 2019 and diagnosed with lung carcinoma were retrospectively analyzed.
Results: Our study shows that the frequency of lung cancer, along with histological subtypes, has increased throughout the years. The most common lung cancer type, regardless of gender, is Squamous Cell Carcinoma (SCC), followed by Small Cell Lung Carcinoma (SCLC) and Adenocarcinoma. Adenocarcinoma and SHC were the most common subtypes among females and males, respectively. A significant relationship was observed between gender and histological type (P<0.001).
Conclusion: The data from our study suggest that the incidence of lung cancer increased throughout the years, similar to the data from our country and other developing countries around the world. In terms of subtypes, among developing countries, Adenocarcinoma rate increased while SCC rate decreased. In our study, the most common histological types increased at a similar rate. Adenocarcinoma was the most common lung cancer among females, similar to other developing countries. The most common lung cancer overall remained the same: SCC. This was considered an indication of the unchanged smoking habits of males.

Project Number

yok

References

  • 1. Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, et al. Cancer treatment and survivorship statistics, 2019. CA: a cancer journal for clinicians. 2019;69(5):363-85.
  • 2. Noone A, Howlader N, Krapcho M, Miller D, Brest A, Yu M, et al. SEER cancer statistics review, 1975-2015. Bethesda, MD: National Cancer Institute. 2018.
  • 3. Latimer K, Mott T. Lung cancer: diagnosis, treatment principles, and screening. American family physician. 2015;91(4):250-6.
  • 4. Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JH, Beasley MB, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. Journal of thoracic oncology. 2015;10(9):1243-60.
  • 5. Goksel T, Akkoclu A. Pattern of lung cancer in Turkey, 1994-1998. Turkish Thoracic Society, Lung and Pleural Malignancies Study Group. Respiration. 2002;69:207-10.
  • 6. Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, et al. The global burden of cancer 2013. JAMA oncology. 2015;1(4):505-27.
  • 7. Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung cancer. Annals of global health. 2019;85(1).
  • 8. Lewis DR, Check DP, Caporaso NE, Travis WD, Devesa SS. US lung cancer trends by histologic type. Cancer. 2014;120(18):2883-92.
  • 9. Goss PE, Strasser-Weippl K, Lee-Bychkovsky BL, Fan L, Li J, Chavarri-Guerra Y, et al. Challenges to effective cancer control in China, India, and Russia. The lancet oncology. 2014;15(5):489-538.
  • 10. Osmani L, Askin F, Gabrielson E, Li QK, editors. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Seminars in cancer biology; 2018: Elsevier.
  • 11. Zheng M. Classification and pathology of lung cancer. Surgical Oncology Clinics. 2016;25(3):447-68.
  • 12. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of thoracic oncology. 2011;6(2):244-85.
  • 13. Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, et al. Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clinical Cancer Research. 2014;20(22):5777-86.
  • 14. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, et al. Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Archives of Pathology and Laboratory Medicine. 2013;137(5):685-705.
  • 15. Myers DJ, Wallen JM. Cancer, Lung Adenocarcinoma. StatPearls (Internet): StatPearls Publishing; 2019.
  • 16. Li C, Lu H. Adenosquamous carcinoma of the lung. OncoTargets and therapy. 2018;11:4829.
  • 17. Youlden DR, Cramb SM, Baade PD. The International Epidemiology of Lung Cancer: geographical distribution and secular trends. Journal of Thoracic Oncology. 2008;3(8):819-31.
  • 18. Bircan HA, Öztürk Ö, Şahin Ü, Özaydın N, Akkaya A. Akciğer kanseri tanısı alan olgularımızın Retrospektif değerlendirilmesi. SDÜ Tıp Fakültesi Dergisi. 2005;12(3):1-6.
  • 19. Yurdakul AS, Çalışır HC, Demirağ F, Taci N, Öğretensoy M. Akciğer kanserinin histolojik tiplerinin dağılımı. Toraks Dergisi. 2002;3(1):59-65.
There are 19 citations in total.

Details

Primary Language English
Subjects Pathology
Journal Section Research article
Authors

Sevilay Özmen 0000-0002-1973-6101

Onur Ceylan 0000-0001-7025-0521

Project Number yok
Publication Date February 1, 2020
Published in Issue Year 2020 Volume: 4 Issue: 2

Cite

APA Özmen, S., & Ceylan, O. (2020). Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. Journal of Surgery and Medicine, 4(2), 112-115. https://doi.org/10.28982/josam.683464
AMA Özmen S, Ceylan O. Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. J Surg Med. February 2020;4(2):112-115. doi:10.28982/josam.683464
Chicago Özmen, Sevilay, and Onur Ceylan. “Trends in Lung Cancer Incidence Within the Last 10 Years: An Eastern Anatolian Single Center Experience”. Journal of Surgery and Medicine 4, no. 2 (February 2020): 112-15. https://doi.org/10.28982/josam.683464.
EndNote Özmen S, Ceylan O (February 1, 2020) Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. Journal of Surgery and Medicine 4 2 112–115.
IEEE S. Özmen and O. Ceylan, “Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience”, J Surg Med, vol. 4, no. 2, pp. 112–115, 2020, doi: 10.28982/josam.683464.
ISNAD Özmen, Sevilay - Ceylan, Onur. “Trends in Lung Cancer Incidence Within the Last 10 Years: An Eastern Anatolian Single Center Experience”. Journal of Surgery and Medicine 4/2 (February 2020), 112-115. https://doi.org/10.28982/josam.683464.
JAMA Özmen S, Ceylan O. Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. J Surg Med. 2020;4:112–115.
MLA Özmen, Sevilay and Onur Ceylan. “Trends in Lung Cancer Incidence Within the Last 10 Years: An Eastern Anatolian Single Center Experience”. Journal of Surgery and Medicine, vol. 4, no. 2, 2020, pp. 112-5, doi:10.28982/josam.683464.
Vancouver Özmen S, Ceylan O. Trends in lung cancer incidence within the last 10 years: An Eastern Anatolian single center experience. J Surg Med. 2020;4(2):112-5.