ALLYLATION OF ARYL GRIGNARD REAGENTS IN THE PRESENCE OF TRANSITION METAL CATALYSIS AND ORGANIC CATALYSIS

Year 2017, Volume: 4 Issue: 3, 877 - 888, 18.08.2017

Melike Kalkan

https://doi.org/10.18596/jotcsa.318333

Abstract

The allylation
yield and regioselectivity of phenyl Grignard reagent in THF was investigated
in the presence of complexed transition metals and also uncomplexed or
complexed transition metal salts. Additionally, the effect of Lewis acids and
Lewis baseson the yield and the regioselectivity of the allylic arylation was
also observed. Neither P-containing ligands for transition metal complexes, nor
transition metal salts did make a difference on the yield and a:g product ratio
and gave the is a-product as the main product. However, donor cosolvents resulted in
decrease in the yield and change of the regioselectivity.

Keywords

Allylic arylation, Transition metal salts/complexes, Organic catalyst, regioselectivity

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