Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Year 2018, Volume: 5 Issue: 2, 493 - 510, 01.01.2018

Gülmira Özek

https://doi.org/10.18596/jotcsa.389075

Cited By: 10

Abstract

Two samples of Tanacetum
praeteritum (Horwood) Heywood subsp. praeteritum
(Horwood) were collected in flowering period and subjected separately to
hydrodistillation to yield the essential oils (A and B). The oils were
investigated for chemical composition with GC-FID and GC/MS techniques and
evaluated against acetylcholinesterase and a-amylase enzymes and
free radicals (DPPH^• and ABTS^•+) using microtiter plate
assays. Both of the oils were characterized with high abundance of oxygenated
monoterpenes. The oils were distinguished by the main constituents, namely,
camphor (37.6 %), 1,8-cineole (19.5 %) and terpinen-4-ol (9.3 %) were found as
the major constituents in the oil A, while a-thujone (79.4 %) and
b-thujone
(8.5 %) were detected in the oil B. The oils demonstrated significant
inhibitory (80 % and 60.0 %) potentials on acetylcholinesterase (an IC₅₀
of 0.74 mg/mL and an IC₅₀ of 1.78 mg/mL, respectively) which
involved into Alzheimer’s disease. With respect to antidiabetic activity, the
oils demonstrated significant inhibiting potential on porcine pancreatic a-amylase
(an IC₅₀ of 1.02 mg/mL and an IC₅₀ of 0.89 mg/mL) in I₂/KI
assay. The oils demonstrated weak free radical scavenging activity against DPPH
radicals and moderate activity (0.23 mM and 0.15 mM) against ABTS^+•
in TEAC assay.

Keywords

Tanacetum; oil; chemical composition; GC/MS; activity

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