Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Year 2018, Volume: 5 Issue: 2, 551 - 568, 01.01.2018

Fatih Yılmaz , Özlem Faiz

https://doi.org/10.18596/jotcsa.390928

Cited By: 6

Abstract

In this work, 15 different coumarin hydrazides were successfully synthesized
and screened for their antioxidant and antilipase activities. To do this,
firstly, salicylaldehyde derivatives and 2,2-dimethyl-1,3-dioxane-4,6-dione
(Meldrum's Acid) were reacted in ethanol in the presence  of catalytic amount of pyridine to obtain
coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds
were treated with benzotriazole in dichloromethane by using thionyl chloride to
synthesized benzotriazole derivatives (2a-e).
Then, compounds 2a-e were reacted
with three commercial hydrazides (nicotinic hydrazide, benzhydrazide and
phenylacetichydrazide) in ethanol by using microwave irradiation and
conventional heating procedures to obtain final products (3-5a-e). Finally, these compounds were tested for their anti-oxidant
and anti-pancreatic lipase activities. The structure of newly synthesized
compounds was identified by ¹H NMR, ¹³C NMR and elemental
analysis data.

Keywords

coumarin, hydrazide, pancreatic lipase

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