2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery

Year 2019, Volume: 6 Issue: 1, 29 - 34, 15.05.2019

Fatih Mehmet Emen , Ruken Esra Demirdöğen , Göktürk Avşar , Derya Kılıç

https://doi.org/10.18596/jotcsa.467177

Cited By: 1

Abstract

Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41
was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO₂)
environment. 2-chloro-benzoythiourea modified MCM-41 was prepared
and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections
observed at low angle XRD show the mesoporous SiO₂ structure. The
paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET
surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m²/g
2-chloro-benzoythiourea
modified MCM-4, respectively. The absorption and
releasing studies of ibuprofen were caried out in simulated body fluid. The
result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea
modified MCM-41 and slower drug release rate was achieved.

Keywords

Drug delivery system(DDS), mesoporous MCM-41

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