Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Year 2019, Volume: 6 Issue: 1, 1 - 14, 15.05.2019

Şebnem Şenol , Emel Akyol

https://doi.org/10.18596/jotcsa.485817

Cited By: 3

Abstract

The aim of the present study is to
develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for
release of Donepezil HCl for potential treatment of Alzheimer’s disease.
[2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651),  1 Hydroxycyclohexyl phenyl ketone (Irgacure
184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure
2959)  were used as photo-initiators in
the synthesis of hydrogels and 
hydroxyapatite was used for modifying hydrogels. Fourier transform
infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital
microscope were utilized to investigate the characteristics properties of hydrogels.
Photopolymerization technique was selected to synthesize for hydrogels.  Swelling and drug release studies have been
performed under different pH conditions.

Keywords

Hydrogels, Photopolymerization, Donepezil HCl, Polyethylene diacyrlate, Alzheimer's Disease

References

• 1. Hagel V, Haraszti T, Boehm H. Diffusion and Interaction in PEG-DA Hydrogels. Biointerphases. 2013;8:36.
• 2. Rahimi S, Khoee S, Ghandi M. Development of Photo and pH Dual Crosslinked Coumarin-Containing Chitosan Nanoparticles for Controlled Drug Release, Carbohydrate Polymers. 2018;201:236-45.
• 3. Dash S, Murthy P.N, Nath L, Chowdhury P. Kinetic Modeling On Drug Release From Controlled Drug Delivery Systems. Polish Pharmaceutical Society. 2010;67:217-23.
• 4. Senol S, Akyol E. Synthesis and Characterization of Hydrogels Based on poly(2-hydroxyethyl methacrylate) for Drug Delivery Under UV Irradiation. Journal of Materials Science. 2018; 53:14953-63.
• 5. Akyol E, Senol S, Dogan O. Controlled Release of Donepezil Hydrochloride From the Ternary Sodium Alginate Based Hydrogels. Bulgarian Chemical Communications. 2017;49:57-63.
• 6. Wang Z, Zhang H, Chu J.A, Jackson J, Lin K, lim C.J, Lange D, Chiao M. Mechanically Enhanced Nested-Network Hydrogels as a Coating Material for Biomedical Devices. Acta Biomaterialia. 2018;70:98-109.
• 7. Ponnuvelu D.V, Kim S, Lee J. Polyethyleneglycol Diacrylate Hydrogels with Plasmonic Gold Nanospheres Incorporated via Functional Group Optimization. Micro and Nano Systems Letters. 2017;5:21.
• 8. Chiu Y-C, Brey E.M, Pérez-Luna M.B. A Study of the Intrinsic Autofluorescence of Poly(ethylene glycol)-co-(L-Lactic acid) Diacrylate. J Fluoresc.2012;22:907–13.
• 9. Ayhan H, Ayhan F. Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery. Turk J Biochem. 2014; 39(4):403–15.
• 10.Ural-Kayalık H, Çetin S. Synthesis and Drug-release Properties of Biodegradable Hydrogels Having b-cyclodextrin. JOTCSA. 2017;4(1):415–30.
• 11. Bat E. Hydroxyethyl Methacrylate-based Nanocomposite Hydrogels with Tunable Pore Architecture. JOTCSA. 2016;3(3):607–22.
• 12. Garćıa-Uriostegui L, Delgado E, Melendez-Ortiz H.I., Camacho-Villegas T.A. , Esquivel-Solís H, Gatenholm p, Toriz G. Carbohydrate Polymers.2018; 201:490-9.
• 13. Islas L, Burillo G, Ortega A. Graft Copolymerization of 2-Hydroxyethyl Methacrylate onto Chitosan Using Radiation Technique for Release of Diclofenac. Macromolecular Research. 2018;26:690-5.
• 14. Cao X-Y, Wen F, Bian W, Cao Y, Pang S-J, Zhang W-K. Preparation and comparison study of hydroxyapatite and Eu-hydroxyapatite. Front. Mater. Sci. 2009;3:255–8.
• 15. Sani T, Adem M, Fetter G, Bosch P, Diaz I. Defluoridation Performance Comparison of Nanohydrotalcite/Hydroxyapatite Composite with Calcined Hydrotalcite and Hydroxyapatite. Water Air Soil Pollut. 2016;227:90.
• 16. Verma D, Kattı S-K, Kattı D-R. Effect of Biopolymers on Structure of Hydroxyapatite and Interfacial Interactions in Biomimetically Synthesized Hydroxyapatite/Biopolymer Nanocomposites. Annals of Biomedical Engineering. 2008;36:1024-32.
• 17. Göktürk S. Effect of Hydrophobicity on Micellar Binding of Carminic Acid. Journal of Photochemistry and Photobiology A: Chemistry. 2005: 169:115-21.
• 18. Ayhan H, Ayhan F. Water based PHEMA Hydrogels for Controlled Drug Delivery. Turk J Biochem. 2017;43:3.
• 19. Kamoun E-A, Abu-Seaid M.A., Doma A.S., Menzel H, Chen X. Influence of Degree of Substitution and Folic Acid Coinitiator on pullulan-HEMA Hydrogel Properties Crosslinked Under Visible Light Initiating system. Biomac. 2018;116:1175-85.
• 20. Liew K-B, Tan Y.T.F, Peh K-K. Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease. AAPS PharmSciTech. 2012;13:134-42.
• 21. Zheng H, Niu S, Zhao H, Li S, Jiao J. Donepezil Improves the Cognitive Impairment in a Tree Shrew Model of Alzheimer’s Disease Induced by Amyloid-β1–40 via Activating the BDNF/TrkB Aignal Pathway. Metabolic Brain Disease.2018;1-14.
• 22. Wang Y-R, Yang Y-H, Lu C-Y, Lin S-H, Chen S-H. Trace Analysis of Acetylcholinesterase Inhibitors with Antipsychotic Drugs for Alzheimer’s Disease by Capillary Electrophoresis with on Column Field-Amplified Sample Injection , Anal Bioanal Chem.2013;405:3233–42.
• 23. Cutuli D, Bartolo P.B., Caporali P, Tartaglione A-M.,Oddi D, D’Amato F-R, Nobli A, D’Amelio M, Petrosini L. Neuroprotective Effects of Donepezil Against Cholinergic Depletion. Alzheimer's Research & Therapy.2013;5:50.
• 24. Choi Y, Rhee S-J, Jang I-J, Yu K-S, Yim S-V, Kim B-H. Bioequivalence Study of Donepezil Hydrochloride in Healthy Korean Volunteers. Transl Clin Pharmacol. 2015;23(1):26-30.
• 25. Abonassıf M.A, Hefnawy M.M, Kassem M.G, Mostafa G.A.E. Determination of Donepezil Hydrochloride In Human Plasma and Pharmaceutical Formulations by HPLC with Fluorescence Detection. Acta Pharm. 2011; 61:403–13.
• 26. Barot T.G., Patel P.K. RP-HPLC Method for the Estimation of Donepezil Hydrochloride Dosage Form. E-Journal of Chemistry. 2009;6(2):594-600.
• 27. Chothe P.P, Subramanian R.C., Kadam V.J. Stability Assessment Of Donepezil Hydrochloride Using Validated RP-HPLC Method. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2010;1(3):296.
• 28. Lakka NS, Goswami N. Solubility and Dissolution Profile Studies of Gliclazide in Pharmaceutical Formulations by HPLC. Int Res J Pharm. 2012; 3(6):126–9.
• 29. Senol S, Akyol E. Controlled Release of Donepezil Hydrochloride From PEG-DA Hydrogels. Bulgarian Chemical Communications. 2018; 50:12-17.