Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine Schiff bases

Year 2019, Volume: 6 Issue: 2, 157 - 164, 15.06.2019

Süleyman Akocak , Nabih Lolak Muhammed Tuneg Mehmet Boga

https://doi.org/10.18596/jotcsa.521291

Cited By: 7

Abstract

In this work, a series of histamine Schiff bases H(1-20) were synthesized by reacting
histamine and substituted aldehydes A(1-20).
The compounds were assayed for antioxidant properties by using different
bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation
radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal
chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase
(BChE) inhibition profiles were also assessed. In general, the synthesized
compounds showed weak antioxidant activity against all tested methods, but some
of the compounds showed great inhibition potency against AChE and BChE enzymes.
Specifically, compound H9 showed
effective inhibition potency against both enzymes with % inhibition of 97.03
and 93.64, respectively.  

Keywords

Histamine, Schiff base, antioxidant, anticholinesterase

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