ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Year 2019, Volume: 6 Issue: 3, 429 - 432, 20.10.2019

Hülya Çelik Onar , Fatma Ceren Anlaş Hasniye Yaşa , Fulya Üstün Alkan , Belma Hasdemir , Tülay Bakırel

https://doi.org/10.18596/jotcsa.583845

Abstract

This study was undertaken to examine the possible
cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic
acids (3.125 – 100 µM)
on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC₅₀
concentrations were recorded at 1.952 µM and 54.00 µM, respectively. 

Keywords

Anilide, Semicarbazone, Fatty Acid, Canine mammary tumor

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