Microwave and ultrasound promoted greener synthesis of thiazolyl-pyrazoline derivatives and investigation of their biological activities

Year 2020, Volume: 7 Issue: 1, 25 - 36, 15.02.2020

Arif Mermer

https://doi.org/10.18596/jotcsa.563286

Cited By: 6

Abstract

Six
thiazolyl-pyrazoline derivatives were synthesized starting from
corresponding chalcone compounds for their antioxidant capacity and antiurease inhibitory activities. In addition
to the conventional method, ultrasonic sonication and microwave irradiation
methods which are environmental methods were
used in the synthesis stage. Compound
2-(5-(3-bromophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenyl thiazole (5a) exhibited the most potent antiurease
activity with IC₅₀ of 2,28±0,02, which was comparable to the
positive control.

Keywords

Thiazole, microwave irradiation, Ultrasound sonication, Biological activity

Thanks

Prof. Dr. Neslihan Demirbaş, Prof. Dr. Ahmet Demirbaş, Chemist MSc Yakup Şirin

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