Research Article
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Year 2020, Volume: 7 Issue: 2, 617 - 634, 23.06.2020
https://doi.org/10.18596/jotcsa.718274

Abstract

References

  • 1. Irakli M, Tsifodimou K, Sarrou E, Chatzopoulou P. Optimization Infusions Conditions for Improving Phenolic Content and Antioxidant Activity in Sideritis scardica Tea Using Response Surface Methodology. J Appl Res Med Aromat Plants. 2018;8:67–74.
  • 2. Silveira TFF da, Meinhart AD, Ballus CA, Godoy HT. The Effect of the Duration of Infusion, Temperature, and Water Volume on the Rutin Content in the Preparation of Mate Tea Beverages: An Optimization Study. Food Res Int. 2014;60:241–5.
  • 3. Goulas V, Exarchou V, Kanetis L, Gerothanassis IP. Evaluation of the Phytochemical Content, Antioxidant Activity and Antimicrobial Properties of Mountain Tea (Sideritis syriaca) Decoction. J Funct Foods. 2013;6:248–58.
  • 4. Ozer Z. Investigation of Phenolic Compounds and Antioxidant Activity of Mentha spicata L. subsp. spicata and M. longifolia (L.) subsp. typhoides (Briq.) Harley Decoction and Infusion. JOTCSA.2018;5(2):445-456.
  • 5. Güvenç A, Duman H. Morphological and Anatomical Studies of Annual Taxa of Sideritis L. (Lamiaceae), With Notes on Chorology in Turkey. Turk J Bot. 2010;34:83–104.
  • 6. Obon de Castro C, Rivera–Nunez D. A Taxonomic revision of the section Sideritis genus Sideritis (Labiatae). In: Cramer J (Eds.), Berlin–Stuttgart, pp 86. 1994.
  • 7. Fraga BM. Phytochemistry and Chemotaxonomy of Sideritis Species from the Mediterranean Region. Phytochemistry. 2012;76:7–24.
  • 8. González-Burgos E, Carretero ME, Gómez-Serranillos MP. Sideritis spp.: Uses, Chemical Composition and Pharmacological Activities— A review. J Etnopharmacol. 2011;135:209–25.
  • 9. Kilic T, Topcu G, Goren AC, Aydogmus Z, Karagoz A, Yildiz YK, Aslan I. Ent-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities. Rec Nat Prod. 2020; 14(4):256-268.
  • 10. Çarıkçı S, Özer Z, Dereli S, Açar D, Gören AC, Kılıç T. Essential Oil Composition of Five Sideritis Species Endemic to Turkey. SDU J Nat Appl Sci. 2018;22(Special Issue):301–305.
  • 11. Çarıkçı S, Kılıç T, Azizoğlu A, Topçu G. Chemical Constituents of Two Endemic Sideritis Species from Turkey with Antioxidant Activity. Rec Nat Prod. 2012;2:101–109.
  • 12. Halfon B, Çiftçi E, Topçu G. Flavonoid Constituents of Sideritis caesarea. Turk J Chem. 2013;37:464–472.
  • 13. Sagir ZO, Carikci S, Kilic T, Goren AC. Metabolic Profile and Biological Activity of Sideritis brevibracteata P. H. Davis Endemic to Turkey. Int J Food Prop. 2017;20(12):2994–3005.
  • 14. Özer Z, Gören AC, Kılıç T, Öncü M, Çarıkçı S, Dirmenci, T. The Phenolic Contents, Antioxidant and Anticholinesterase Activity of Section Amaracus (Gled.) Vogel and Anatolicon Ietsw. of Origanum L. Species. Arab J Chem. 2020; 13:5027-5039.
  • 15. Vasilopoulou CG, Kontogianni VG, Linardaki ZI. Phytochemical Composition of "Mountain Tea" from Sideritis clandestina subsp. clandestina and Evaluation of Its Behavioral and Oxidant / Antioxidant Effects on Adult Mice. Eur J Nutr. 2013;107–116.
  • 16. Danesi F, Saha S, Kroon PA, Glibeti M. Bioactive-rich Sideritis scardica tea (Mountain Tea) is as Potent as Camellia sinensis Tea at Inducing Cellular Antioxidant Defences and Preventing Oxidative Stress. J Sci Food Agric. 2013:3558–3564.
  • 17. Petreska J, Stefova M, Ferreres F, Moreno DA, Tomás-barberán FA, Stefkov G, et al. Potential Bioactive Phenolics of Macedonian Sideritis species Used for Medicinal "Mountain Tea". Food Chem. 2011;125:13–20.
  • 18. Selvi S, Dağdelen A, Kara S. Medicinal and Aromatic Plants Consumed as Herbal Tea and Collected from Ida Mountains (Balıkesir -Edremit). J Tekirdag Agricul Facul. 2013;10(2):26-33.
  • 19. Kirimer N, Baser KHC, Demirci B, Duman H. Essential Oils of Sideritis Species of Turkey Belonging to the Section Empedoclia. Chem Nat Compd. 2004; 40:18–21.
  • 20. Kirmizibekmez H, Karaca N, Demirci B, Demirci F. Characterization of Sideritis trojana Bornm. Essential Oil and Its Antimicrobial Activity. Marmara Pharm J. 2017; 21(4): 860-865.
  • 21. Topçu G, Gören A, Kılıç T, Yıldız YK, Tümen G. Diterpenes from Sideritis trojana. Nat Prod Lett. 2002; 16:33–37.
  • 22. Kirmizibekmez H, Ariburnu E, Masullo M, Festa M, Capasso A, Yesilada E, Piacente S. Iridoid, Phenylethanoid and Flavonoid Glycosides from Sideritis trojana. Fitoterapia. 2012; 83:130–136.
  • 23. Oztürk Y, Aydin S, Öztürk N, Başer KHC. Effects of Extracts from Certain Sideritis Species on Swimming Performance in Mice. Phytotherapy Res 1996; 10:70–73.
  • 24. Celep E, Seven M, Akyüz S, İnan Y, Yesilada E. Influence of Extraction Method on Enzyme Inhibition, Phenolic Profile and Antioxidant Capacity of Sideritis trojana Bornm. S Afr J Bot. 2019; 121:360-365.
  • 25. Özek T, Baser KHC. The Essential Oil of Sideritis athoa Papanikolaou et Kokkini. J Essent Oil Res. 1993; 5:669–670.
  • 26. Kilic T, Goren AC, Tumen G, Topcu G. Phytochemical Analysis of Some Sideritis Species of Turkey. Chem Nat Comp. 2003;39:373–374.
  • 27. Topçu G, Gören AC, Yildiz YK, Tümen G. Ent-kaurene Diterpenes from Sideritis athoa. Nat Prod Lett. 1999; 14(2):123-129.
  • 28. Dulger B, Gonuz A, Aysel V. Inhibition of Clotrimazole-resistant Candida albicans by Some Endemic Sideritis Species from Turkey. Fitoterapia. 2006; 77:404–405.
  • 29. Aslan I, Kılıç T, Gören AC, Topçu G. Toxicity of Acetone Extract of Sideritis trojana and (Say), Sitophilus granarius (L.) and Ephestia kuehniella (Zel.). Ind Crop Prod. 2006; 23:171–176.
  • 30. Blois MS. Antioxidant Determinations by the Use of A Stable Free Radical. Nature.1958;181:1199-1200.
  • 31. Marco GJ. A Rapid Method for Evaluation of Antioxidants. J American Oil Chem Soc. 1968; 45:594-598.
  • 32. Apak R, Güclü K, Özyürek M, Celik S E. Mechanism of Antioxidant Capacity Assays and the CUPRAC (cupric ion reducing antioxidant capacity) assay. Microchimica Acta. 2008;160(4):413-419.
  • 33. Ellman GL, Courtney KD, Andres V, Featherston RM. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem Pharmacol 1961; 7: 88-95.
  • 34. Charami MT, Lazari D, Karioti A, Skaltsa H, Hadjipavlou-Litina D, Souleles C. Antioxidant and Antiinflammatory Activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae). Phytother Res. 2008;22:450-454.
  • 35. Gabrieli CN, Kefalas PG, Kokkalou EL. Antioxidant Activity of Flavonoids from Sideritis raeseri. J Etnopharmacol 2005; 96:423–428.
  • 36. Kirmizibekmez H, Ariburnu E, Masullo M, Festa M, Capasso A, Yesilada E, et al. Iridoid, Phenylethanoid and Flavonoid Glycosides from Sideritis trojana. Fitoterapia. 2012;83(1):130–136.
  • 37. Deveci E, Tel-çayan G, Duru ME. Phenolic Profile, Antioxidant, Anticholinesterase, and Anti-tyrosinase Activities of the Various Extracts of Ferula elaeochytris and Sideritis stricta. Int J Food Prop 2018; 21:771–783.
  • 38. Zengin G, Sarikurkcu C, Aktumsek A. Sideritis galatica Bornm.: A Source of Multifunctional Agents for the Management of Oxidative Damage, Alzheimer's and Diabetes Mellitus. J Funct Foods. 2014; 11:538-547.
  • 39. Baki S, Tufan AN, Altun M, Özgökçe F, Güçlü K, Özyürek M. Microwave-assisted Extraction of Polyphenolics from Some Selected Medicinal Herbs Grown in Turkey. Rec Nat Prod. 2018; 12(1), 29.
  • 40. Yılmaz H, Çarıkçı S, Kılıç T, Dirmenci T, Arabacı T, Gören AC. Screening of Chemical Composition, Antioxidant and Anticholinesterase Activity of Section Brevifilamentum of Origanum (L.) Species. Rec Nat Prod. 2017; 5:439–455.
  • 41. Gülçin İ. Antioxidant Activity of Food Constituents: An Overview. Arch Toxicol 2012; 86(3):345–391.
  • 42. Vergine M, Nicolì F, Negro C, Luvisi A, Nutricati E, Accogli RA, Sabella E, Miceli A. Phytochemical Profiles and Antioxidant Activity of Salvia species from Southern Italy. Rec Nat Prod. 2019; 13(3):205-215.
  • 43. Erkan N, Cetin H, Ayranci E. Antioxidant Activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr.: Identification of Free Flavonoids and Cinnamic Acid Derivatives. Food Res Int. 2011;44(1):297–303.
  • 44. Silva BA, Malva O, Dias ACP. St. John' s Wort (Hypericum perforatum) Extracts and Isolated Phenolic Compounds are Effective Antioxidants in Several in Vitro Models of Oxidative Stress. Food Chem. 2008;110:611–619.
  • 45. Jaberian H, Piri K, Nazari J. Phytochemical Composition and in Vitro Antimicrobial and Antioxidant Activities of Some Medicinal Plants. Food Chem. 2013; 136(1):237-244.
  • 46. Orhan I, Kartal M, Tosun F, Şener B. Screening of Various Phenolic Acids and Flavonoid Derivatives for Their Anticholinesterase Potential. Z Naturforsch C 2007; 62(11-12):829-832.

Antioxidant and Anticholinesterase Properties of Sideritis perfoliata subsp. athoa (Papan. &Kokkini) Baden and Sideritis trojana Bornm. Teas from Mount Ida-Turkey and Their Phenolic Characterization by LC-MS/MS

Year 2020, Volume: 7 Issue: 2, 617 - 634, 23.06.2020
https://doi.org/10.18596/jotcsa.718274

Abstract

The phenolic profile, antioxidant and anticholinesterase activities of teas prepared from two Sideritis(L.) species: Sideritis perfoliata subsp. athoa (Papan. &Kokkini) Baden. and Sideritis trojana Bornm, collected from Mount Ida (Kaz Dağı) Turkey, were determined. The teas were prepared by infusion and decoction methods. The quantitative amounts of the phenolic contents were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The major phytochemicals were found to be fumaric acid for infusion and decoction samples of S. trojana and infusion of S. perfoliata subsp. athoa, chlorogenic acid for decoction of S. perfoliata subsp. athoa. The tea samples prepared by decoction method were found to be rich in phenolics. Apart from the fact that the decoction sample of S. trojana exhibited the best antioxidant effect in 2, 2-diphenyl-1-picrylhydrazyl (DPPH), β -carotene bleaching and cupric (Cu2+) ion reducing power assay (CUPRAC) methods among the tested samples at all concentrations, and showed significant inhibition effect at 200 μg/mL against acetylcholinesterase and butyrylcholinesterase enzymes (59.74%, 64.99%, respectively).

References

  • 1. Irakli M, Tsifodimou K, Sarrou E, Chatzopoulou P. Optimization Infusions Conditions for Improving Phenolic Content and Antioxidant Activity in Sideritis scardica Tea Using Response Surface Methodology. J Appl Res Med Aromat Plants. 2018;8:67–74.
  • 2. Silveira TFF da, Meinhart AD, Ballus CA, Godoy HT. The Effect of the Duration of Infusion, Temperature, and Water Volume on the Rutin Content in the Preparation of Mate Tea Beverages: An Optimization Study. Food Res Int. 2014;60:241–5.
  • 3. Goulas V, Exarchou V, Kanetis L, Gerothanassis IP. Evaluation of the Phytochemical Content, Antioxidant Activity and Antimicrobial Properties of Mountain Tea (Sideritis syriaca) Decoction. J Funct Foods. 2013;6:248–58.
  • 4. Ozer Z. Investigation of Phenolic Compounds and Antioxidant Activity of Mentha spicata L. subsp. spicata and M. longifolia (L.) subsp. typhoides (Briq.) Harley Decoction and Infusion. JOTCSA.2018;5(2):445-456.
  • 5. Güvenç A, Duman H. Morphological and Anatomical Studies of Annual Taxa of Sideritis L. (Lamiaceae), With Notes on Chorology in Turkey. Turk J Bot. 2010;34:83–104.
  • 6. Obon de Castro C, Rivera–Nunez D. A Taxonomic revision of the section Sideritis genus Sideritis (Labiatae). In: Cramer J (Eds.), Berlin–Stuttgart, pp 86. 1994.
  • 7. Fraga BM. Phytochemistry and Chemotaxonomy of Sideritis Species from the Mediterranean Region. Phytochemistry. 2012;76:7–24.
  • 8. González-Burgos E, Carretero ME, Gómez-Serranillos MP. Sideritis spp.: Uses, Chemical Composition and Pharmacological Activities— A review. J Etnopharmacol. 2011;135:209–25.
  • 9. Kilic T, Topcu G, Goren AC, Aydogmus Z, Karagoz A, Yildiz YK, Aslan I. Ent-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities. Rec Nat Prod. 2020; 14(4):256-268.
  • 10. Çarıkçı S, Özer Z, Dereli S, Açar D, Gören AC, Kılıç T. Essential Oil Composition of Five Sideritis Species Endemic to Turkey. SDU J Nat Appl Sci. 2018;22(Special Issue):301–305.
  • 11. Çarıkçı S, Kılıç T, Azizoğlu A, Topçu G. Chemical Constituents of Two Endemic Sideritis Species from Turkey with Antioxidant Activity. Rec Nat Prod. 2012;2:101–109.
  • 12. Halfon B, Çiftçi E, Topçu G. Flavonoid Constituents of Sideritis caesarea. Turk J Chem. 2013;37:464–472.
  • 13. Sagir ZO, Carikci S, Kilic T, Goren AC. Metabolic Profile and Biological Activity of Sideritis brevibracteata P. H. Davis Endemic to Turkey. Int J Food Prop. 2017;20(12):2994–3005.
  • 14. Özer Z, Gören AC, Kılıç T, Öncü M, Çarıkçı S, Dirmenci, T. The Phenolic Contents, Antioxidant and Anticholinesterase Activity of Section Amaracus (Gled.) Vogel and Anatolicon Ietsw. of Origanum L. Species. Arab J Chem. 2020; 13:5027-5039.
  • 15. Vasilopoulou CG, Kontogianni VG, Linardaki ZI. Phytochemical Composition of "Mountain Tea" from Sideritis clandestina subsp. clandestina and Evaluation of Its Behavioral and Oxidant / Antioxidant Effects on Adult Mice. Eur J Nutr. 2013;107–116.
  • 16. Danesi F, Saha S, Kroon PA, Glibeti M. Bioactive-rich Sideritis scardica tea (Mountain Tea) is as Potent as Camellia sinensis Tea at Inducing Cellular Antioxidant Defences and Preventing Oxidative Stress. J Sci Food Agric. 2013:3558–3564.
  • 17. Petreska J, Stefova M, Ferreres F, Moreno DA, Tomás-barberán FA, Stefkov G, et al. Potential Bioactive Phenolics of Macedonian Sideritis species Used for Medicinal "Mountain Tea". Food Chem. 2011;125:13–20.
  • 18. Selvi S, Dağdelen A, Kara S. Medicinal and Aromatic Plants Consumed as Herbal Tea and Collected from Ida Mountains (Balıkesir -Edremit). J Tekirdag Agricul Facul. 2013;10(2):26-33.
  • 19. Kirimer N, Baser KHC, Demirci B, Duman H. Essential Oils of Sideritis Species of Turkey Belonging to the Section Empedoclia. Chem Nat Compd. 2004; 40:18–21.
  • 20. Kirmizibekmez H, Karaca N, Demirci B, Demirci F. Characterization of Sideritis trojana Bornm. Essential Oil and Its Antimicrobial Activity. Marmara Pharm J. 2017; 21(4): 860-865.
  • 21. Topçu G, Gören A, Kılıç T, Yıldız YK, Tümen G. Diterpenes from Sideritis trojana. Nat Prod Lett. 2002; 16:33–37.
  • 22. Kirmizibekmez H, Ariburnu E, Masullo M, Festa M, Capasso A, Yesilada E, Piacente S. Iridoid, Phenylethanoid and Flavonoid Glycosides from Sideritis trojana. Fitoterapia. 2012; 83:130–136.
  • 23. Oztürk Y, Aydin S, Öztürk N, Başer KHC. Effects of Extracts from Certain Sideritis Species on Swimming Performance in Mice. Phytotherapy Res 1996; 10:70–73.
  • 24. Celep E, Seven M, Akyüz S, İnan Y, Yesilada E. Influence of Extraction Method on Enzyme Inhibition, Phenolic Profile and Antioxidant Capacity of Sideritis trojana Bornm. S Afr J Bot. 2019; 121:360-365.
  • 25. Özek T, Baser KHC. The Essential Oil of Sideritis athoa Papanikolaou et Kokkini. J Essent Oil Res. 1993; 5:669–670.
  • 26. Kilic T, Goren AC, Tumen G, Topcu G. Phytochemical Analysis of Some Sideritis Species of Turkey. Chem Nat Comp. 2003;39:373–374.
  • 27. Topçu G, Gören AC, Yildiz YK, Tümen G. Ent-kaurene Diterpenes from Sideritis athoa. Nat Prod Lett. 1999; 14(2):123-129.
  • 28. Dulger B, Gonuz A, Aysel V. Inhibition of Clotrimazole-resistant Candida albicans by Some Endemic Sideritis Species from Turkey. Fitoterapia. 2006; 77:404–405.
  • 29. Aslan I, Kılıç T, Gören AC, Topçu G. Toxicity of Acetone Extract of Sideritis trojana and (Say), Sitophilus granarius (L.) and Ephestia kuehniella (Zel.). Ind Crop Prod. 2006; 23:171–176.
  • 30. Blois MS. Antioxidant Determinations by the Use of A Stable Free Radical. Nature.1958;181:1199-1200.
  • 31. Marco GJ. A Rapid Method for Evaluation of Antioxidants. J American Oil Chem Soc. 1968; 45:594-598.
  • 32. Apak R, Güclü K, Özyürek M, Celik S E. Mechanism of Antioxidant Capacity Assays and the CUPRAC (cupric ion reducing antioxidant capacity) assay. Microchimica Acta. 2008;160(4):413-419.
  • 33. Ellman GL, Courtney KD, Andres V, Featherston RM. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem Pharmacol 1961; 7: 88-95.
  • 34. Charami MT, Lazari D, Karioti A, Skaltsa H, Hadjipavlou-Litina D, Souleles C. Antioxidant and Antiinflammatory Activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae). Phytother Res. 2008;22:450-454.
  • 35. Gabrieli CN, Kefalas PG, Kokkalou EL. Antioxidant Activity of Flavonoids from Sideritis raeseri. J Etnopharmacol 2005; 96:423–428.
  • 36. Kirmizibekmez H, Ariburnu E, Masullo M, Festa M, Capasso A, Yesilada E, et al. Iridoid, Phenylethanoid and Flavonoid Glycosides from Sideritis trojana. Fitoterapia. 2012;83(1):130–136.
  • 37. Deveci E, Tel-çayan G, Duru ME. Phenolic Profile, Antioxidant, Anticholinesterase, and Anti-tyrosinase Activities of the Various Extracts of Ferula elaeochytris and Sideritis stricta. Int J Food Prop 2018; 21:771–783.
  • 38. Zengin G, Sarikurkcu C, Aktumsek A. Sideritis galatica Bornm.: A Source of Multifunctional Agents for the Management of Oxidative Damage, Alzheimer's and Diabetes Mellitus. J Funct Foods. 2014; 11:538-547.
  • 39. Baki S, Tufan AN, Altun M, Özgökçe F, Güçlü K, Özyürek M. Microwave-assisted Extraction of Polyphenolics from Some Selected Medicinal Herbs Grown in Turkey. Rec Nat Prod. 2018; 12(1), 29.
  • 40. Yılmaz H, Çarıkçı S, Kılıç T, Dirmenci T, Arabacı T, Gören AC. Screening of Chemical Composition, Antioxidant and Anticholinesterase Activity of Section Brevifilamentum of Origanum (L.) Species. Rec Nat Prod. 2017; 5:439–455.
  • 41. Gülçin İ. Antioxidant Activity of Food Constituents: An Overview. Arch Toxicol 2012; 86(3):345–391.
  • 42. Vergine M, Nicolì F, Negro C, Luvisi A, Nutricati E, Accogli RA, Sabella E, Miceli A. Phytochemical Profiles and Antioxidant Activity of Salvia species from Southern Italy. Rec Nat Prod. 2019; 13(3):205-215.
  • 43. Erkan N, Cetin H, Ayranci E. Antioxidant Activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr.: Identification of Free Flavonoids and Cinnamic Acid Derivatives. Food Res Int. 2011;44(1):297–303.
  • 44. Silva BA, Malva O, Dias ACP. St. John' s Wort (Hypericum perforatum) Extracts and Isolated Phenolic Compounds are Effective Antioxidants in Several in Vitro Models of Oxidative Stress. Food Chem. 2008;110:611–619.
  • 45. Jaberian H, Piri K, Nazari J. Phytochemical Composition and in Vitro Antimicrobial and Antioxidant Activities of Some Medicinal Plants. Food Chem. 2013; 136(1):237-244.
  • 46. Orhan I, Kartal M, Tosun F, Şener B. Screening of Various Phenolic Acids and Flavonoid Derivatives for Their Anticholinesterase Potential. Z Naturforsch C 2007; 62(11-12):829-832.
There are 46 citations in total.

Details

Primary Language English
Subjects Organic Chemistry
Journal Section Articles
Authors

Sema Çarıkçı 0000-0003-3657-9926

Publication Date June 23, 2020
Submission Date April 11, 2020
Acceptance Date June 15, 2020
Published in Issue Year 2020 Volume: 7 Issue: 2

Cite

Vancouver Çarıkçı S. Antioxidant and Anticholinesterase Properties of Sideritis perfoliata subsp. athoa (Papan. &Kokkini) Baden and Sideritis trojana Bornm. Teas from Mount Ida-Turkey and Their Phenolic Characterization by LC-MS/MS. JOTCSA. 2020;7(2):617-34.