Cefoperazone metal complexes and their antimicrobial investigations

Year 2021, Volume: 8 Issue: 2, 375 - 390, 31.05.2021

Mehmet Emin Çınar Taner Erdoğan , Ayşegül Gölcü

https://doi.org/10.18596/jotcsa.721414

Cited By: 1

Abstract

Transition metal (Cd(II), Co(II), Cu(II), Fe(III), Ni(II), Pd(II), Pt(II), Ru(III), Zn(II)) complexes of cefoperazone (CFP) were synthesized and their spectroscopic (IR, UV-Vis), magnetic, thermal (DTA-TG) and mass investigations were conducted to characterize the metal-based complexes. Detailed insights into the electronic structures were provided by performing density functional theory (DFT) computations. Their antimicrobial studies were realized rendering their activities compared to that of the commercial cefoperazone.

Keywords

Cefoperazone, metal complexes, antimicrobial studies, computation

Supporting Institution

TUBITAK

Project Number

105T371

Thanks

The authors wish to thank TUBITAK (Project No: 105T371) for the financial support; Kahramanmaras Sutcu Imam University, Chemistry Department for laboratory environments; and Kahramanmaras Sutcu Imam University, Biology Department for cell culture studies. We thank the Istanbul Technical University for the laboratory (L105) facilities to redo the experiments. We are indebted to the Kocaeli University for the computer time provided.

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