Review Article
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Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review

Year 2023, Volume: 6 Issue: 1, 43 - 56, 21.06.2023

Rebaz Omer , Rzgar Farooq Rashid , Khdir Othman

https://doi.org/10.54565/jphcfum.1263834
Cited By: 4

Abstract

The pharmacological activities of triazole derivatives have been studied extensively by researchers. Different derivatives of triazole have showed promise in treating various diseases. Most triazole derivatives have demonstrated anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal activities. The ability of these compounds to modulate various biological processes has made them attractive for pharmaceutical development. Furthermore, the low cost and wide availability of triazoles have made them even more attractive for drug development. In addition to the pharmacological activities, triazole derivatives have also been reported to possess antioxidant properties. Studies have shown that 1,2,3-triazole can protect against oxidative damage and inhibit lipid peroxidation. Furthermore, 1,2,4-triazole has been found to act as an antioxidant and scavenge free radicals. The antioxidant properties of triazoles make them attractive for the development of new drugs. The synthesis of triazole derivatives has also been studied extensively. Various methods have been developed to synthesize triazole derivatives, including chemical and enzymatic methods. Chemical methods involve the formation of cyclic structures by the reaction of alkyl halides with azides. Enzymatic methods involve the use.

Keywords

Synthesis 1,2,4-Triazole Derivatives Triazole derivatives Triazole substituted

Supporting Institution

Koya university

Project Number

NO

References

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Year 2023, Volume: 6 Issue: 1, 43 - 56, 21.06.2023

Rebaz Omer , Rzgar Farooq Rashid , Khdir Othman

https://doi.org/10.54565/jphcfum.1263834
Cited By: 4

Abstract

Project Number

NO

References

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  • 2. L.-P. Guan, et al., Synthesis and anticonvulsant activity of a new 6-alkoxy-[1, 2, 4] triazolo [4, 3-b] pyridazine. European journal of medicinal chemistry, 2010. 45(5): p. 1746-1752.
  • 3. N. Siddiqui and W. Ahsan, Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening. European journal of medicinal chemistry, 2010. 45(4): p. 1536-1543.
  • 4. R.A. Omar, A.K. Smail, and K.A. Omar, Study on the activity of Ag/Nylon 6, 10 nanocomposite against Escherichia coli. Int. J. Curr. Microbiol. App. Sci, 2016. 5(4): p. 935-941.
  • 5. R. Kaur, et al., Recent developments on 1, 2, 4-triazole nucleus in anticancer compounds: a review. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2016. 16(4): p. 465-489.
  • 6. K. Ilango and P. Valentina, Synthesis and biological activities of novel 1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazole. Der Pharma Chemica, 2010. 2(2): p. 16-22.
  • 7. K. Arul and K. Smith, In-Silico Design, Synthesis and In Vitro Anticancer Evaluation of Some Novel 1, 2, 4-Triazole Derivatives. The Experiment, 2014. 21(1): p. 1439-1452.
  • 8. C. Kurumurthy, et al., Synthesis of novel alkyltriazole tagged pyrido [2, 3-d] pyrimidine derivatives and their anticancer activity. European journal of medicinal chemistry, 2011. 46(8): p. 3462-3468.
  • 9. R.A. Omer, Antimicrobial Activity of Nylon Nanocomposites Against Staphylococcus Aureus and Escherichia Coli Bacteria. Science Journal of University of Zakho, 2019. 7(4): p. 138-143.
  • 10. Y.H. Alaraji, J.K. Shneine, and A.N.A.A. Ahmed, Journal of Science Chemistry.
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  • 12. H.A. Bay, et al., Synthesis and biological activity of new triazole compounds. Letters in Drug Design & Discovery, 2010. 7(1): p. 41-45.
  • 13. N.B. Patel, I.H. Khan, and S.D. Rajani, Pharmacological evaluation and characterizations of newly synthesized 1, 2, 4-triazoles. European journal of medicinal chemistry, 2010. 45(9): p. 4293-4299.
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  • 15. S. Sripriya, C. Subha, and A. Selvaraj, The inhibition chemistry of 2-amino, 5-phenyl 1, 3, 4-triazole for aluminium in hydrochloric acid solution. IOSRJAC, 2013. 6(2): p. 25-29.
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  • 17. O. Bekircan, et al., Synthesis of Some New 1, 2, 4‐Triazole Derivatives Starting from 3‐(4‐Chlorophenyl)‐5‐(4‐methoxybenzyl)‐4H‐1, 2, 4‐triazol with Anti‐Lipase and Anti‐Urease Activities. Archiv Der Pharmazie, 2014. 347(6): p. 387-397.
  • 18. V. Sharma, et al., Exploring potential of 1, 2, 4-triazole: a brief review. Pharmacol. Online, 2011. 1: p. 1192-1222.
  • 19. M. Asif, A mini review on antimalarial activities of biologically active substituted triazoles derivatives. Int J Adv Res Chem Sci, 2014. 1: p. 22-28.
  • 20. R. Satyendra, et al., Synthesis, in vitro antioxidant, anthelmintic and molecular docking studies of novel dichloro substituted benzoxazole-triazolo-thione derivatives. European journal of medicinal chemistry, 2011. 46(7): p. 3078-3084.
  • 21. D. Swarnkar, R. Ameta, and R. Vyas, Microwave-assisted synthesis of some 1, 3, 4-oxadiazole derivatives and evaluation of their antibacterial and antifungal activity. Organic Chemistry International, 2014. 2014.
  • 22. A. Husain, M.A. Naseer, and M. Sarafroz, Synthesis and anticonvulsant activity of some novel fused heterocyclic 1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazole derivatives. Acta Pol Pharm, 2009. 66(2): p. 135-40.
  • 23. C. Deliwala, et al., Synthesis and hypoglycemic activity of 3-aryl (or pyridyl)-5-alkyl (or aryl) amino-1, 3, 4-thiadiazoles and some sulfonylurea derivatives of 4H-1, 2, 4-triazoles. Journal of medicinal chemistry, 1971. 14(10): p. 1000-1003.
  • 24. R. Hunashal, et al., Synthesis, anti-inflammatory and analgesic activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1, 2, 4-triazol-3-yl thio] acetic acid derivatives. Arabian Journal of Chemistry, 2014. 7(6): p. 1070-1078.
  • 25. K.P. Barot, K.S. Manna, and M.D. Ghate, Design, synthesis and antimicrobial activities of some novel 1, 3, 4-thiadiazole, 1, 2, 4-triazole-5-thione and 1, 3-thiazolan-4-one derivatives of benzimidazole. Journal of Saudi Chemical Society, 2017. 21: p. S35-S43.
  • 26. S. Eswaran, A.V. Adhikari, and N.S. Shetty, Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1, 2, 4-triazole moiety. European journal of medicinal chemistry, 2009. 44(11): p. 4637-4647.
  • 27. N.G. Salunkhe, Green synthesis, characterization and biological evaluation of some triazole and thiadiazole. J. Curr. Chem. Pharm. Sc, 2012. 2(2).
  • 28. N.U. Güzeldemirci and Ö. Küçükbasmacı, Synthesis and antimicrobial activity evaluation of new 1, 2, 4-triazoles and 1, 3, 4-thiadiazoles bearing imidazo [2, 1-b] thiazole moiety. European journal of medicinal chemistry, 2010. 45(1): p. 63-68.
  • 29. G.S. Kumar, et al., Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1, 2, 4-triazole and 1, 3, 4-oxadiazoles as potential antimicrobial and antitubercular agents. European Journal of Medicinal Chemistry, 2010. 45(5): p. 2063-2074.
  • 30. M. Hassam, et al., Novel cyclopropyl-indole derivatives as HIV non-nucleoside reverse transcriptase inhibitors. ACS medicinal chemistry letters, 2012. 3(6): p. 470-475.
  • 31. P. Kaur, R. Kaur, and M. Goswami, A review on methods of synthesis of 1, 2, 4-triazole derivatives. IRJP, 2018. 9: p. 1-35.
  • 32. W.K. Jassim, A.A. Fayad, and I.K. Jassim, Synthesis and characterization of some substituted heterocyclic compounds and evaluation of biological activity. karbala journal of pharmaceutical sciences, 2011(2): p. 228-240.
  • 33. M. Hanif, et al., Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-amino-5-aryl-3H-1, 2, 4-triazole-3-thiones and their 3, 6-disubstituted 1, 2, 4-triazolo [3, 4-b] 1, 3, 4-thiadiazole derivatives. Journal of the Brazilian Chemical Society, 2012. 23(5): p. 854-860.
  • 34. M.G. Al-Khuzaie and S.M. Al-Majidi, Synthesis, characterization and evaluation antimicrobial activity of some new substituted 2-mercapto-3-phenyl-4 (3H)-quinazolinone. Iraqi Journal of Science, 2014. 55(2Supplement): p. 582-593.
  • 35. I.S. Krishnanjaneyulu, et al., Synthesis, characterization and antimicrobial activity of some novel benzimidazole derivatives. Journal of advanced pharmaceutical technology & research, 2014. 5(1): p. 21.
  • 36. S. Chen, et al., Quantum chemical study of some benzimidazole and its derivatives as corrosion ınhibitors of steel in HCl solution. Int. J. Electrochem. Sci, 2014. 9: p. 5400-5408.
  • 37. R. Singh, et al., Design and synthesis of new bioactive 1, 2, 4-triazoles, potential antitubercular and antimicrobial agents. Indian Journal of Pharmaceutical Sciences, 2018. 80(1): p. 36-45.
  • 38. Y.J. Mange, et al., Synthesis and antimicrobial activities of some novel 1, 2, 4-triazole derivatives. Arabian Journal of Chemistry, 2013. 6(2): p. 177-181.
  • 39. F.A. Yassin and A.F. Seleim, Synthesis and reactions of oxadiazolo, thiadiazolo and triazolo phthalazin-1 (2H)-one derivatives. Pharma Chem, 2012. 4(3): p. 860-866.
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There are 69 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Articles
Authors

Rebaz Omer 0000-0002-3774-6071

Rzgar Farooq Rashid 0000-0002-0846-9888

Khdir Othman This is me 0000-0002-7763-2976

Project Number NO
Publication Date June 21, 2023
Submission Date March 12, 2023
Acceptance Date April 15, 2023
Published in Issue Year 2023 Volume: 6 Issue: 1

Cite

APA Omer, R., Rashid, R. F., & Othman, K. (2023). Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review. Journal of Physical Chemistry and Functional Materials, 6(1), 43-56. https://doi.org/10.54565/jphcfum.1263834
AMA Omer R, Rashid RF, Othman K. Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review. Journal of Physical Chemistry and Functional Materials. June 2023;6(1):43-56. doi:10.54565/jphcfum.1263834
Chicago Omer, Rebaz, Rzgar Farooq Rashid, and Khdir Othman. “Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review”. Journal of Physical Chemistry and Functional Materials 6, no. 1 (June 2023): 43-56. https://doi.org/10.54565/jphcfum.1263834.
EndNote Omer R, Rashid RF, Othman K (June 1, 2023) Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review. Journal of Physical Chemistry and Functional Materials 6 1 43–56.
IEEE R. Omer, R. F. Rashid, and K. Othman, “Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review”, Journal of Physical Chemistry and Functional Materials, vol. 6, no. 1, pp. 43–56, 2023, doi: 10.54565/jphcfum.1263834.
ISNAD Omer, Rebaz et al. “Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review”. Journal of Physical Chemistry and Functional Materials 6/1 (June 2023), 43-56. https://doi.org/10.54565/jphcfum.1263834.
JAMA Omer R, Rashid RF, Othman K. Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review. Journal of Physical Chemistry and Functional Materials. 2023;6:43–56.
MLA Omer, Rebaz et al. “Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review”. Journal of Physical Chemistry and Functional Materials, vol. 6, no. 1, 2023, pp. 43-56, doi:10.54565/jphcfum.1263834.
Vancouver Omer R, Rashid RF, Othman K. Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review. Journal of Physical Chemistry and Functional Materials. 2023;6(1):43-56.

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