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Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?

Year 2010, Volume: 2 Issue: 6, 1 - 5, 28.12.2010

Surhan Arda , Dilsad Derelı Huseyin Ilhan , Baran Tokar

Abstract

The etiology of gastric perforation in newborn has not been described yet. It is a rare pathology and has been accepted mostly as spontaneously occurring. In this case report, we present a newborn who was admitted with hematemesis, hematochezia, abdominal distension and pneumoperitoneum at the abdominal x-ray. A gastric perforation was found at abdominal exploration. The symptoms, signs and our exploration findings support a strong possibility of association of low molecular weight heparin (LMWH) and the gastric perforation. LMWH treatment during the pregnancy may cause a massive gastric bleeding in baby so that gastric outlet obstruction with coagulum plug and perforation may occur secondarily.

Keywords

newborn low molecular weight heparin gastric perforation

References

  • Soo AI, Gye-Yeo L, Hahn ST. Spontaneous gastric perforation in a neonate presenting with massive hydroperitoneum Pediatr Radiol 2005; 35:1212-14
  • Kawasey Y , Ishıı T, Arai H and Uga N. Gastrointestinal perforation in very low- birthweight infants Pediatrics International 2006; 48:599-603
  • Jawad AJ et al. Spontaneous neonatal gastric perforation Pediatric Surgery Int 2002; 18:396-99
  • Leone RJ, Krasna IH Spontaneous neonatal gastric perforation: Is it really spontaneous? Journal of Pediatric Surgery 2000; 35:1066-69
  • Carmen R, Tayyaba H, Milner et al. Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy. Blood Coagulation and Firinolysis 2008; 19: 689-92.
  • Deruellea P, Coulonb C. The use of low- molecular-weight heparins in pregnancy – how safe are they? Current Opininon in Obstetrics and Gynecology 2007; 19:573-77.
  • Maslovitz S, Many A, Landsberg JA et al. The safety of low molecular weight heparin therapy during labor. The Journal of Maternal- Fetal and Neonatal Medicine, 2005; 17:39-43
  • Grosfeld JL, Molinari F, Chaet M, Engum SA, West KW, Rescorla FJ, Scherer LR 3rd. Gastrointestinal perforation and peritonitis in infants and children: experience with 179 cases over ten years. Surgery 1996;120:650- 55
  • Pelizzo G, Dubois R, Lapillonne A, Laine X, Claris O, Bouvir R, Chappuis JP. Gastric necrosis in newborn: a report of 11 cases. Pediatr Surg Int 1998; 13:346-49.
  • Abadir J, Emil S, Nguyen N. Abdominal foregut yearexperience. JPediatr Surg 2005;40:1903- 07. inchildren: a10
  • Kara CS, Ilce Z, Celayir S, Sarimurat N, Erdogan E, Yeker D. Neonatal gastric perforation: review of 23 years'experience. SurgToday 2004;34:243-45. 12. Gauderer MW.Percutaneous
  • gastrostomy-20 years later: a historical
  • perspective. J Pediatr Surg. 2001;36:217-19.
  • Lyold JR: The etiology of gastrointestinal perforation in the newborn.J pediatr Surg 1969; 4:77-84
  • Lylod J, Espiasse E,Bernstein J: Etiology of gastrointestinal Harper Hosp Bull 1964; 22:224 in newborn. 15. Richard J Leone, Irwin H. Krasna. 'Spontaneous' neonatal gastric perforation: is it really spontaneous? J Pediatr Surg 2000; 35: 1066-69.
  • Miserez M,Barten S, Geboes K,et al:surgical thearpy and histological abnormalities in functional isolated small bowel obstruction and idiopathic gastrointestinal perforation in very low birth weight infant. World J Surg 2003;27:350-55 17. Shoerter N,Liu J ,Money D et al: İndomethacin- associated bowel perforation: A study of possible risk factors. J pediatr Surg 1999;34:442-44

Year 2010, Volume: 2 Issue: 6, 1 - 5, 28.12.2010

Surhan Arda , Dilsad Derelı Huseyin Ilhan , Baran Tokar

Abstract

References

  • Soo AI, Gye-Yeo L, Hahn ST. Spontaneous gastric perforation in a neonate presenting with massive hydroperitoneum Pediatr Radiol 2005; 35:1212-14
  • Kawasey Y , Ishıı T, Arai H and Uga N. Gastrointestinal perforation in very low- birthweight infants Pediatrics International 2006; 48:599-603
  • Jawad AJ et al. Spontaneous neonatal gastric perforation Pediatric Surgery Int 2002; 18:396-99
  • Leone RJ, Krasna IH Spontaneous neonatal gastric perforation: Is it really spontaneous? Journal of Pediatric Surgery 2000; 35:1066-69
  • Carmen R, Tayyaba H, Milner et al. Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy. Blood Coagulation and Firinolysis 2008; 19: 689-92.
  • Deruellea P, Coulonb C. The use of low- molecular-weight heparins in pregnancy – how safe are they? Current Opininon in Obstetrics and Gynecology 2007; 19:573-77.
  • Maslovitz S, Many A, Landsberg JA et al. The safety of low molecular weight heparin therapy during labor. The Journal of Maternal- Fetal and Neonatal Medicine, 2005; 17:39-43
  • Grosfeld JL, Molinari F, Chaet M, Engum SA, West KW, Rescorla FJ, Scherer LR 3rd. Gastrointestinal perforation and peritonitis in infants and children: experience with 179 cases over ten years. Surgery 1996;120:650- 55
  • Pelizzo G, Dubois R, Lapillonne A, Laine X, Claris O, Bouvir R, Chappuis JP. Gastric necrosis in newborn: a report of 11 cases. Pediatr Surg Int 1998; 13:346-49.
  • Abadir J, Emil S, Nguyen N. Abdominal foregut yearexperience. JPediatr Surg 2005;40:1903- 07. inchildren: a10
  • Kara CS, Ilce Z, Celayir S, Sarimurat N, Erdogan E, Yeker D. Neonatal gastric perforation: review of 23 years'experience. SurgToday 2004;34:243-45. 12. Gauderer MW.Percutaneous
  • gastrostomy-20 years later: a historical
  • perspective. J Pediatr Surg. 2001;36:217-19.
  • Lyold JR: The etiology of gastrointestinal perforation in the newborn.J pediatr Surg 1969; 4:77-84
  • Lylod J, Espiasse E,Bernstein J: Etiology of gastrointestinal Harper Hosp Bull 1964; 22:224 in newborn. 15. Richard J Leone, Irwin H. Krasna. 'Spontaneous' neonatal gastric perforation: is it really spontaneous? J Pediatr Surg 2000; 35: 1066-69.
  • Miserez M,Barten S, Geboes K,et al:surgical thearpy and histological abnormalities in functional isolated small bowel obstruction and idiopathic gastrointestinal perforation in very low birth weight infant. World J Surg 2003;27:350-55 17. Shoerter N,Liu J ,Money D et al: İndomethacin- associated bowel perforation: A study of possible risk factors. J pediatr Surg 1999;34:442-44
There are 16 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Surhan Arda

Dilsad Derelı This is me

Huseyin Ilhan

Baran Tokar

Publication Date December 28, 2010
Published in Issue Year 2010 Volume: 2 Issue: 6

Cite

APA Arda, S., Derelı, D., Ilhan, H., Tokar, B. (2010). Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?. Journal of Pediatric Sciences, 2(6), 1-5. https://doi.org/10.17334/jps.55396
AMA Arda S, Derelı D, Ilhan H, Tokar B. Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?. Journal of Pediatric Sciences. November 2010;2(6):1-5. doi:10.17334/jps.55396
Chicago Arda, Surhan, Dilsad Derelı, Huseyin Ilhan, and Baran Tokar. “Low Molecular Weight Heparin Therapy During Gestation: Is It Really Innocent for Both Mother and Fetus?”. Journal of Pediatric Sciences 2, no. 6 (November 2010): 1-5. https://doi.org/10.17334/jps.55396.
EndNote Arda S, Derelı D, Ilhan H, Tokar B (November 1, 2010) Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?. Journal of Pediatric Sciences 2 6 1–5.
IEEE S. Arda, D. Derelı, H. Ilhan, and B. Tokar, “Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?”, Journal of Pediatric Sciences, vol. 2, no. 6, pp. 1–5, 2010, doi: 10.17334/jps.55396.
ISNAD Arda, Surhan et al. “Low Molecular Weight Heparin Therapy During Gestation: Is It Really Innocent for Both Mother and Fetus?”. Journal of Pediatric Sciences 2/6 (November 2010), 1-5. https://doi.org/10.17334/jps.55396.
JAMA Arda S, Derelı D, Ilhan H, Tokar B. Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?. Journal of Pediatric Sciences. 2010;2:1–5.
MLA Arda, Surhan et al. “Low Molecular Weight Heparin Therapy During Gestation: Is It Really Innocent for Both Mother and Fetus?”. Journal of Pediatric Sciences, vol. 2, no. 6, 2010, pp. 1-5, doi:10.17334/jps.55396.
Vancouver Arda S, Derelı D, Ilhan H, Tokar B. Low Molecular Weight Heparin therapy during gestation: is it really innocent for both mother and fetus?. Journal of Pediatric Sciences. 2010;2(6):1-5.