Properties of Chlorogenic Acid as a Skin Fibroblast Antiaging Agent with Apoptosis Inhibition and Free Radical Scavenging Activities

Year 2025, Volume: 29 Issue: 1, 159 - 167, 03.03.2025

Ermi Girsang Nyoman Ehrich Lister Chrismis Novalinda Ginting Wahyu Widowati , Afif Yati Hanna Sari Widya Kusuma , Rizal Azis

https://doi.org/10.12991/jrespharm.1628594

Abstract

Aging is a skin phenomenon that is caused intrinsically by tissue degeneration and extrinsically by environmental toxicity including ultraviolet (UV) exposure, manifested as wrinkles and skin damage respectively. Chlorogenic acid (CA) possesses roles as antiinflammation and antioxidation by reducing reactive oxygen species (ROS). The present study examined CA anti-aging activities toward skin fibroblast (BJ) cells induced by UV. Antiaging properties of CA were analyzed by assessing the levels of collagen-1α1 (COL-1α1), elastin (ELN), 8-hydroxy 2 deoxyguanosine (8-OHdG), melatonin (MT), and hyaluronidase (HAase), and by quantifying the percentages of living cells, dead cells. CA treatment on aging cells diminished the 8-OHdG, HAase, and a percentage of apoptotic cells. It also improved the levels of COL-1α1, ELN, MT, and the proportion of living cells. This study proved CA ability as an antiaging agent through its roles as a free radical scavenger and anti-apoptotic agent.

Keywords

antiaging, chlorogenic acid, fibroblast, skin, UV

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