Appendix neuroendocrine tumors: A single center experience

Year 2023, Volume: 16 Issue: 2, 40 - 44, 08.08.2023

Haldun Kar , Erdinç Kamer , Halis Bağ , Cengiz Tavusbay , Emine Özlem Gür , Betül Bolat Küçükzeybek , Mehmet Haciyanli

Abstract

Appendiceal neuroendocrine neoplasms (ANENs) comprise approximately 30-80% of appendicular tumors. ANENs are frequently encountered incidental and account for 0.1 percent to 3 percent of appendecto-mies. Well-differentiated ANENs have a favorable prognosis with a 5-year survival rate in almost all patients with local disease. In this study, we evaluated the clinical findings, risk factors, and clinical output data and revealed the most accurate approach in light of the literature.
In this retrospective single-center study, the files of patients who underwent an appendectomy either as appendicitis or as a part of another abdominal surgical procedure histopathological diagnosed with neuroendoc-rine tumors in the last 14 years were entered into the study.
Between January 2009 and January 2023, 5818 patients underwent appendectomy. The pathology of 36 patients (0.61%) was an appendiceal neuroendocrine tumor. Complementary right hemicolectomy was per-formed in 6 (20.6%) patients. Lymph node metastasis and/or residual tumor are not observed. In this group, three of the 4 patients in the gray zone had R1 resection and one had perforated appendicitis. Surgery was re-commended for patients with a tumor diameter of 2 cm, mesoappendix invasion, and a tumor diameter of 2 cm located at the base, but the patients did not accept it. There is no recurrence or metastasis in the patients fol-lowed.
To reduce radical surgical procedures of appendiceal neuroendocrine tumors located in the gray zone, R1 resection, and perforation detected, the operation information and pathology reports of these cases should be evaluated in multidisciplinary tumor boards. High-volume studies with multicenter participation on this sub-ject should be conducted

Keywords

appendix, neuroendocrine tumors, right hemicolectomy, overtreatment

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