Research Article
BibTex RIS Cite

Inappropriate Shocks in Patients with Implantable Cardioverter Defibrillator: Demographics and Predictors

Year 2017, Volume: 20 Issue: 3, 230 - 234, 03.12.2017

Abstract

Introduction: Inappropriate
ICD shocks may negatively affect the quality of life and lead to arrhythmias
and psychiatric problems. In this study, we investigated demographic and
clinical characteristics of patients with ICD shocks and the predictors leading
to inappropriate ICD shocks presented to our emergency department.



Patients and Methods:
A
total of 64 patients with ICD shocks presented to the emergency department were
included in the study. Clinical data of the patients were retrospectively
obtained. The clinical features, left ventricular ejection fraction (LVEF),
drugs used, and electrocardiographic (ECG) data at the time of implantation of
the patients were obtained.



Results: Of the
patients presented, 82% were male and the mean age was found as 56.6 ± 15.8
years. Fourty-nine (76%) and 15 (34%) patients experienced appropriate and
inappropriate ICD shocks, respectively. The most common findings in the
patients presented with inappropriate ICD shocks included atrial fibrillation
in 8 (53%), supraventricular tachycardia in 6 (40%), and lead sensing problem
in 1 (7%) patients. Compared with the patients presented with appropriate
shocks, patients with inappropriate ICD shocks were younger, had less coronary
artery disease, had more history of atrial fibrillation before implantation,
and shorter time from implantation to first inappropriate shock. In
multivariate logistic regression analysis, age and a history of atrial
fibrillation were found as independent predictors for inappropriate ICD shocks.



Conclusion: Presence of atrial
fibrillation is the most common rhythm problem that causes inappropriate ICD
shocks. History of previous atrial fibrillation and a younger age are
predicting clinical parameters for inappropriate ICD shocks.

References

  • 1. Connolly SJ, Hallstrom AP, Cappato R, Schron EB, Kuck KH, Zipes DP, et al. Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. Antiarrhythmics vs Implantable Defibrillator study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study. Eur Heart J 2000;21:2071-8.
  • 2. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225-37.
  • 3. Kadish A, Dyer A, Daubert JP, Quigg R, Estes NA, Anderson KP, et al. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 2004;350:2151-8.
  • 4. Kim YH, Kim JS. Clinical characteristics in patients with implantable cardioverter-defibrillator (ICD). Korean Circ J 2004;34:395-404.
  • 5. Cevik C, Perez-Verdia A, Nugent K. Implantable cardioverter defibrillators and their role in heart failure progression. Europace 2009;11:710-5.
  • 6. Schron EB, Exner DV, Yao Q, Jenkins LS, Steinberg JS, Cook JR, et al. Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks. Circulation 2002;105: 589-94.
  • 7. Lüderitz B, Jung W, Deister A, Marneros A, Manz M. Patient acceptance of the implantable cardioverter defibrillator in ventricular tachyarrhythmias. Pacing Clin Electrophysiol 1993;16:1815-21.
  • 8. Bhavnani SP, Giedrimiene D, Coleman CI, Guertin D, Azeem M, Kluger J. The healthcare utilization and cost of treating patients experiencing inappropriate implantable cardioverter defibrillator shocks: a propensity score study. Pacing Clin Electrophysiol 2014;37:1315-23.
  • 9. Poole JE, Johnson GW, Hellkamp AS, Anderson J, Callans DJ, Raitt MH, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008;359:1009-17.
  • 10. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015;36:2793-867.
  • 11. Kühlkamp V, Dörnberger V, Mewis C, Suchalla R, Bosch RF, Seipel L. Clinical experience with the new detection algorithms for atrial fibrillation of a defibrillator with dual chamber sensing and pacing. J Cardiovasc Electrophysiol 1999;10:905-15.
  • 12. Higgins SL, Lee RS, Kramer RL. Stability: an ICD detection criterion for discriminating atrial fibrillation from ventricular tachycardia. J Cardiovasc Electrophysiol 1995;6:1081-8.
  • 13. Yang JH, Byeon K, Yim HR, Park JW, Park SJ, Huh J, et al. Predictors and clinical impact of inappropriate implantable cardioverter-defibrillator shocks in Korean patients. J Korean Med Sci 2012;27:619-24.
  • 14. Fernández-Cisnal A, Arce-León Á, Arana-Rueda E, Rodríguez-Mañero M, González-Cambeiro C, Moreno-Arribas J, et al. Analyses of inappropriate shocks in a Spanish ICD primary prevention population: Predictors and prognoses. Int J Cardiol 2015;195:188-94.
  • 15. Van Rees JB, Borleffs CJ, de Bie MK, Stijnen T, van Erven L, Bax JJ, et al. Inappropriate implantable cardioverter-defibrillator shocks: incidence, predictors, and impact on mortality. J Am Coll Cardiol 2011;57:556-62
  • 16. Daubert JP, Zareba W, Cannom DS, McNitt S, Rosero SZ, Wang P, et al. Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact. J Am Coll Cardiol 2008;51:1357-65.
  • 17. Bhavnani SP, Coleman CI, White CM, Clyne CA, Yarlagadda R, Guertin D, et al. Association between statin therapy and reductions in atrial fibrillation or flutter and inappropriate shock therapy. Europace 2008;10:854-9.
  • 18. Hreybe H, Ezzeddine R, Barrington W, Bazaz R, Jain S, Ngwu O, et al. Relation of advanced heart failure symptoms to risk of inappropriate defibrillator shocks. Am J Cardiol 2006;97:544-6.
  • 19. Safak E, D’Ancona G, Ince H. Inappropriate shocks after implantable cardioverter-defibrillator for primary prevention in idiopathic cardiomyopathy: Independent determinants. Int J Cardiol 2016;223:512-3.
  • 20. Soundarraj D, Thakur RK, Gardiner JC, Khasnis A, Jongnarangsin K. Inappropriate ICD therapy: does device configuration make a difference. Pacing Clin Electrophysiol 2006;29:810-5.
  • 21. Theuns DA, Klootwijk AP, Simoons ML, Jordaens LJ. Clinical variables predicting inappropriate use of implantable cardioverter defibrillator in patients with coronary heart disease or nonischemic dilated cardiomyopathy. Am J Cardiol 2005;95:271-4.

İmplante Kardiyoverter Defibrilatör Yapılan Hastalarda Uygunsuz-Şoklama: Demografik Özellikler ve Öngördürücüler

Year 2017, Volume: 20 Issue: 3, 230 - 234, 03.12.2017

Abstract

Giriş: Uygunsuz implante edilen kardiyoverter defibrilatör (ICD) şokları yaşam
kalitesini olumsuz etkileyebilir, aritmiye ve psikiyatrik sorunlara yol
açabilir. Biz çalışmamızda acil servisimize ICD şoklamasıyla başvuran
hastaların demografik, klinik özeliklerini ve uygunsuz ICD şoklamasına yol açan
öngördürücüleri araştırdık.



Hastalar ve
Yöntem:
Acil servise ICD şoklamasıyla başvuran 64 hasta
çalışmaya alındı. Hastalara ait klinik veriler retrospektif olarak elde edildi.
Çalışmaya dahil edilen hastaların klinik özelikleri, sol ventrikül ejeksiyon
fraksiyonu (LVEF), kullandıkları ilaçlar, implantasyon anındaki
elektrokardiyogramlarına (EKG) ait veriler elde edildi.



Bulgular: Başvuran hastaların %82’si erkek ve ortalama yaş (56.6 ± 15.8) tespit
edildi. Kırk dokuz (%76) hastada  uygun
şoklama tespit edilirken 15 (%34) hastada uygunsuz ICD şoklaması tespit edildi.
Uygunsuz ICD şoklama ile başvuran 
hastalarda sırasıyla en sık atriyal fibrilasyon (AF) 8 (%53), supraventriküler
taşikardi 6 (%40) ve lead algılama sorunu 1 (%7) hastada  saptandı. Uygunsuz ICD şoklaması olan
hastalar uygun şoklamayla başvuran hastalarla kıyaslandığında daha genç yaşa,
daha az koroner arter hastalığına, implantasyon öncesi  daha fazla AF öyküsüne ve implantasyondan
sonra ilk şoklamaya kadar  daha kısa
süreye sahip olan hastalardı. Multivariate logistik regresyon analizi sonrası
yaş, AF öyküsü varlığı uygunsuz ICD şoklaması için bağımsız öngördürücü olduğu
bulundu.



Sonuç: AF varlığı uygunsuz ICD
şoklamasına neden olan  en sık ritm
sorunudur. Daha önce AF öyküsünün olması ve genç yaşta olmak, uygunsuz ICD
şoklaması için öngördürücü klinik parametrelerdir.

References

  • 1. Connolly SJ, Hallstrom AP, Cappato R, Schron EB, Kuck KH, Zipes DP, et al. Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. Antiarrhythmics vs Implantable Defibrillator study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study. Eur Heart J 2000;21:2071-8.
  • 2. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225-37.
  • 3. Kadish A, Dyer A, Daubert JP, Quigg R, Estes NA, Anderson KP, et al. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 2004;350:2151-8.
  • 4. Kim YH, Kim JS. Clinical characteristics in patients with implantable cardioverter-defibrillator (ICD). Korean Circ J 2004;34:395-404.
  • 5. Cevik C, Perez-Verdia A, Nugent K. Implantable cardioverter defibrillators and their role in heart failure progression. Europace 2009;11:710-5.
  • 6. Schron EB, Exner DV, Yao Q, Jenkins LS, Steinberg JS, Cook JR, et al. Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks. Circulation 2002;105: 589-94.
  • 7. Lüderitz B, Jung W, Deister A, Marneros A, Manz M. Patient acceptance of the implantable cardioverter defibrillator in ventricular tachyarrhythmias. Pacing Clin Electrophysiol 1993;16:1815-21.
  • 8. Bhavnani SP, Giedrimiene D, Coleman CI, Guertin D, Azeem M, Kluger J. The healthcare utilization and cost of treating patients experiencing inappropriate implantable cardioverter defibrillator shocks: a propensity score study. Pacing Clin Electrophysiol 2014;37:1315-23.
  • 9. Poole JE, Johnson GW, Hellkamp AS, Anderson J, Callans DJ, Raitt MH, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008;359:1009-17.
  • 10. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015;36:2793-867.
  • 11. Kühlkamp V, Dörnberger V, Mewis C, Suchalla R, Bosch RF, Seipel L. Clinical experience with the new detection algorithms for atrial fibrillation of a defibrillator with dual chamber sensing and pacing. J Cardiovasc Electrophysiol 1999;10:905-15.
  • 12. Higgins SL, Lee RS, Kramer RL. Stability: an ICD detection criterion for discriminating atrial fibrillation from ventricular tachycardia. J Cardiovasc Electrophysiol 1995;6:1081-8.
  • 13. Yang JH, Byeon K, Yim HR, Park JW, Park SJ, Huh J, et al. Predictors and clinical impact of inappropriate implantable cardioverter-defibrillator shocks in Korean patients. J Korean Med Sci 2012;27:619-24.
  • 14. Fernández-Cisnal A, Arce-León Á, Arana-Rueda E, Rodríguez-Mañero M, González-Cambeiro C, Moreno-Arribas J, et al. Analyses of inappropriate shocks in a Spanish ICD primary prevention population: Predictors and prognoses. Int J Cardiol 2015;195:188-94.
  • 15. Van Rees JB, Borleffs CJ, de Bie MK, Stijnen T, van Erven L, Bax JJ, et al. Inappropriate implantable cardioverter-defibrillator shocks: incidence, predictors, and impact on mortality. J Am Coll Cardiol 2011;57:556-62
  • 16. Daubert JP, Zareba W, Cannom DS, McNitt S, Rosero SZ, Wang P, et al. Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact. J Am Coll Cardiol 2008;51:1357-65.
  • 17. Bhavnani SP, Coleman CI, White CM, Clyne CA, Yarlagadda R, Guertin D, et al. Association between statin therapy and reductions in atrial fibrillation or flutter and inappropriate shock therapy. Europace 2008;10:854-9.
  • 18. Hreybe H, Ezzeddine R, Barrington W, Bazaz R, Jain S, Ngwu O, et al. Relation of advanced heart failure symptoms to risk of inappropriate defibrillator shocks. Am J Cardiol 2006;97:544-6.
  • 19. Safak E, D’Ancona G, Ince H. Inappropriate shocks after implantable cardioverter-defibrillator for primary prevention in idiopathic cardiomyopathy: Independent determinants. Int J Cardiol 2016;223:512-3.
  • 20. Soundarraj D, Thakur RK, Gardiner JC, Khasnis A, Jongnarangsin K. Inappropriate ICD therapy: does device configuration make a difference. Pacing Clin Electrophysiol 2006;29:810-5.
  • 21. Theuns DA, Klootwijk AP, Simoons ML, Jordaens LJ. Clinical variables predicting inappropriate use of implantable cardioverter defibrillator in patients with coronary heart disease or nonischemic dilated cardiomyopathy. Am J Cardiol 2005;95:271-4.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Original Investigations
Authors

Özkan Candan

Publication Date December 3, 2017
Published in Issue Year 2017 Volume: 20 Issue: 3

Cite

Vancouver Candan Ö. İmplante Kardiyoverter Defibrilatör Yapılan Hastalarda Uygunsuz-Şoklama: Demografik Özellikler ve Öngördürücüler. Koşuyolu Heart Journal. 2017;20(3):230-4.