THERAPEUTIC EFFICACY OF MYRTUS COMMUNIS IN SCIATIC NERVE INJURY: AN EXPERIMENTAL RESEARCH IN RATS

Year 2024, , 525 - 535, 21.10.2024

Gökçe Zeytin Demiral , Zülfükar Sarıtaş , Ülkü Türk Börü , Fatma Görücü Özbek , Cansu Köseoğlu Toksoy , Aziz Bülbül , Hasan Hüseyin Demirel , Yusuf Koç , Zehra Yasar Tekmanoglulari

https://doi.org/10.18229/kocatepetip.1520464

Abstract

OBJECTIVE: Nerve injuries, often resulting from various causes, pose serious health issues that typically require prolonged rehabilitation. Conventional methods used in the treatment of these injuries are often inadequate, necessitating the exploration of new treatment approaches. Research on the effects of plant-derived active compounds on nerve regeneration may offer potential new treatment options. In this context, this study investigating the effects of Myrtus communis on nerve regeneration aims to fill an important gap in the field of nerve injury treatment.
MATERIAL AND METHODS: In this study, the efficacy of Myrtus communis was evaluated in an experimental sciatic nerve injury model. Thirty-two female Wistar Albino rats were divided into four groups: Control, Sham, Group I, and Group II. Sciatic nerve injury was induced, and Myrtus communis treatment was administered via gastric lavage. The animals' motor functions, sensory functions, electrophysiological measurements, biochemical parameters, and histopathological evaluations were examined.
RESULTS: The results demonstrated that Myrtus communis contributed to rapid improvement in sciatic functional index (SFI) values. Similarly, positive effects were observed in sensory assessment and electrophysiological measurements. Biochemical analyses indicated that Myrtus communis increased antioxidant capacity and reduced oxidative stress. Histopathological examinations revealed less axon degeneration, edema, and vacuolization in the groups treated with Myrtus communis.
CONCLUSIONS: This study concludes that Myrtus communis could be used as a potential therapeutic agent in the treatment of sciatic nerve injury. These findings suggest that Myrtus communis may play a supportive role in post-nerve injury recovery. However, it should be noted that further research is needed before these results can be translated into clinical applications.

Keywords

Myrtus Communis, Sciatic nerve injury, Therapeutic efficacy, Peripheral, nerve regeneration, Anti-inflammatory effects.

Project Number

21.Genel.016

RATLARDA SİYATİK SİNİR YARALANMASINDA MYRTUS COMMUNIS'İN TERAPÖTİK ETKİNLİĞİ: BİR DENEYSEL ARAŞTIRMA

Abstract

AMAÇ: Sinir yaralanmaları, genellikle çeşitli nedenlerden kaynaklanan ciddi sağlık sorunları olup, genellikle uzun süreli rehabilitasyon gerektirir. Bu yaralanmaların tedavisinde kullanılan geleneksel yöntemler çoğunlukla yetersiz kalmakta ve yeni tedavi yaklaşımlarının araştırılmasını gerektirmektedir. Bitkisel kökenli aktif bileşiklerin sinir rejenerasyonu üzerindeki etkileri üzerine yapılan araştırmalar, potansiyel yeni tedavi seçenekleri sunabilir. Bu bağlamda, Myrtus communis'in sinir rejenerasyonu üzerindeki etkilerini araştıran bu çalışma, sinir yaralanması tedavisi alanında önemli bir boşluğu doldurmayı amaçlamaktadır.
GEREÇ VE YÖNTEM: Bu çalışmada, Myrtus communis'in etkinliği deneysel siyatik sinir yaralanması modelinde değerlendirildi. Otuz iki dişi Wistar Albino sıçan dört gruba ayrıldı: Kontrol, Sham, Grup I ve Grup II. Siyatik sinir yaralanması indüklendi ve Myrtus communis tedavisi gastrik lavaj yoluyla uygulandı. Hayvanların motor fonksiyonları, duyusal fonksiyonları, elektrofizyolojik ölçümleri, biyokimyasal parametreleri ve histopatolojik değerlendirmeleri incelendi.
BULGULAR: Myrtus communis'in siyatik fonksiyonel indeks (SFI) değerlerinde hızlı iyileşmeye katkıda bulunduğunu gösterdi. Benzer şekilde, duyusal değerlendirme ve elektrofizyolojik ölçümlerde de olumlu etkiler gözlendi. Biyokimyasal analizler, Myrtus communis'in antioksidan kapasiteyi artırdığını ve oksidatif stresi azalttığını gösterdi. Histopatolojik incelemeler, Myrtus communis ile tedavi edilen gruplarda daha az akson dejenerasyonu, ödem ve vakuolizasyon olduğunu ortaya koydu.
SONUÇ: Bu çalışma, Myrtus communis'in siyatik sinir yaralanmasının tedavisinde potansiyel bir terapötik ajan olarak kullanılabileceğini sonucuna varmıştır. Bu bulgular, Myrtus communis'in sinir yaralanması sonrası iyileşme sürecinde destekleyici bir rol oynayabileceğini düşündürmektedir. Bununla birlikte, bu sonuçların klinik uygulamalara dönüştürülebilmesi için daha fazla araştırmaya ihtiyaç olduğu unutulmamalıdır.

Keywords

Myrtus Communis, Siyatik sinir hasarı, Terapötik etkinlik, Periferik sinir rejenerasyonu, Anti-inflamatuar etkiler.

Ethical Statement

The Local Ethics Committee for Animal Experiments of Afyon Kocatepe University, Afyonkarahisar, Turkey, approved the study protocol (Issue No: 49533702/04, Date: 20/01/2023).

Supporting Institution

This study was supported by Afyonkarahisar Health Sciences University Scientific Research Projects Coordination Unit with the project number 21.GENEL.016.

Project Number

21.Genel.016

Thanks

None

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