GLOKOM HASTALARINDA SHEAR WAVE ELASTOGRAFİ BULGULARI

Year 2023, , 1 - 7, 03.01.2023

Azad Hekimoğlu , Onur Ergun , Aysun Şanal Dogan , Şule Berk Ergun , Mutlu Acar , Canan Gürdal , Baki Hekimoğlu

https://doi.org/10.18229/kocatepetip.907128

Abstract

AMAÇ: Amacımız glokom hastalarında shear wave elastography (SWE) ile gözün farklı bölgelerindeki sertlik değerlerinin ölçülmesi ve sonuçlarının sağlıklı gözlerle karşılaştırılarak oküler kompartmanların elastisitesinde bir değişiklik olup olmadığının araştırılmasıdır.
GEREÇ VE YÖNTEM: Bu çalışmada açık açılı glokomlu 12 hasta ile 32 sağlıklı gönüllüyü SWE donanımlı ultrasonografi cihazı kullanarak karşılaştırdık. Tüm hastalarda sadece sağ göz değerlendirildi. İlk olarak, göz küresi genellikle B-modunda incelendi. Daha sonra arka segmentte optik sinir başı, retro-orbital sinir, sklera-retina kompleksi ve retro-orbital yağ dokusunun sertlik değerleri ile gözün ön segmentinde kornea, lens ve ön kamara sertlik değerleri kiloPaskal cinsinden ölçüldü. SWE ile ve her iki grup istatistiksel olarak karşılaştırıldı.
BULGULAR: Gözün farklı bölgelerinde yapılan ölçümlerde kaydedilen sertlik değerleri açısından hasta ve kontrol grupları arasında istatistiksel olarak anlamlı bir farklılık bulunmadı.
SONUÇ: SWE kolay uygulanabilir bir yöntem olmasına rağmen, glokom ve kontrol grupları arasında anlamlı bir fark bulunmadı. Ancak bu çalışma ile normal kişilerde gözün farklı bölgeleri için referans değerler belirlenmiştir.

Keywords

Göz, Glokom, Shear wave elastografi, Sertlik, Eye, Glaucoma, Shear-wave elastography, Stiffness

Supporting Institution

yok

SHEAR WAVE ELASTOGRAPHY FINDINGS IN GLAUCOMA PATIENTS

Abstract

OBJECTIVE: Our aim is to measure the stiffness values in different regions of the eye with shear wave elastography (SWE) in patients with glaucoma and to compare the results with healthy eyes to investigate whether there is a change in the elasticity of the ocular compartments in glaucoma patients.
MATERIAL AND METHODS: In this study, we compared 12 patients with open-angle glaucoma and 32 healthy volunteers using an SWE-equipped ultrasonography device. Only the right eye was evaluated in all patients. First, the eye globe was generally examined in B-mode. Then, the stiffness values of the optic nerve head, retro-orbital nerve, sclera-retina complex and retro-orbital adipose tissue in the posterior segment and the stiffness values of the cornea, lens and anterior chamber in the anterior segment of the eye were measured with SWE in kiloPascal and both groups were compared statistically.
RESULTS: No statistically significant differences were found between the patient and control groups in terms of the stiffness values recorded in the measurements performed in different parts of the eye.
CONCLUSIONS: Although SWE is an easily applicable method, no significant differences were found between glaucoma and control groups. However, thanks to this study, reference values for different parts of the eye in normal individuals have been determined.

Keywords

Eye, Glaucoma, Shear-wave elastography, Stiffness

References

• 1. Bhatia KS, Lee YY, Yuen EH, Ahuja AT. Ultrasound elastography in the head and neck. Part I. Basic principles and practical aspects. Cancer Imaging. 2013;13:253-9.
• 2. Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging.1991;13:111-34.
• 3. Ghajarzadeh M, Sodagari F, Shakiba M. Diagnostic accuracy of sonoelastography in detecting malignant thyroid nodules: a systematic review and meta-analysis. AJR Am J Roentgenology. 2014;202:379-89.
• 4. Bhatia KS, Cho CC, Tong CS, et al. Shear wave elasticity imaging of cervical lymph nodes. Ultrasound Med Biol. 2012;38:195-201.
• 5. Gong X, Xu Q, Xu Z, Xiong P, Yan W, Chen Y. Real-time elastography for the differentiation of benign and malignant breast lesions: a meta-analysis. Breast Cancer Res Treat. 2011;130:11-8.
• 6. Hekimoglu A, Tatar IG, Ergun O, Turan A, Aylı MD, Hekimoglu B. Shear wave sonoelastography findings of testicles in cronic kidney disease patients who undergo hemodialysis. Eurasian J Med. 2017;49:12-5.
• 7. Botar Jid C, Vasilescu D, Damian L, Dumitriu D, Ciurea A, Dudea SM. Musculoskeletal sonoelastography. Pictorial essay. Med Ultrason. 2012;14:239-45.
• 8. Sandulescu L, Rogoveanu I, Gheonea IA, Cazacu S, Saftoiu A. Real-time elastography applications in liver pathology between expectations and results. J Gastrointestin Liver Dis. 2013;22:221-7.
• 9. Cochlin DL, Ganatra RH, Griffiths DFR. Elastography in the detection of prostatic cancer. Clin Radiol. 2002;57:1014-20.
• 10. Taljanovic MS, Gimber LH, Becker GW, et al. Shear-Wave Elastography: Basic physics and musculoskeletal applications. Radiographics. 2017;37: 855-70.
• 11. Burnside ES, Hall TJ, Sommer AM, et al. Differentiating benign from malignant solid breast masses with US strain imaging. Radiology. 2007;245:401-10.
• 12. Chang JM, Moon WK, Cho N, Kim SJ. Breast mass evaluation: factors influencing the quality of US elastography. Radiology. 2011;259:59-64.
• 13. Cosgrove DO, Berg WA, Doré CJ, et al. Shear wave elastography for breast masses is highly reproducible. Eur Radiol. 2012;22:1023-32.
• 14. Sarvazyan A. P., Rudenko, O. V., Swanson, S. D., Fowlkes, J. B., & Emelianov, S. Y. Shear Wave elasticity imaging: a new ultrasonic technology of medical diagnostics. Ultrasound in Medicine & Biology .1998;24:1419- 35.
• 15. Bercoff J, Tanter M, Fink M. Supersonic shear imaging: a new technique for soft tissue elasticity mapping. IEEE Trans Ultrason Ferroelectr Freq Control. 2004;51:396-409.
• 16. Chan EW, Li X, Tham YC, et al. Glaucoma in Asia: regional prevalence variations and future projections. Br J Ophthalmol 2016;100:78-85.
• 17. Zetterberg M. Age-related eye disease and gender. Maturitas. 2016;83:19-26.
• 18. Mastropasqua R, Fasanella V, Agnifili L, et al. Advance in the pathogenesis and treatment of normal-tension glaucoma. Prog Brain Res. 2015;221:213-32.
• 19. Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I. Definition of glaucoma: clinical and experimental concepts. Clin Experiment Ophthalmol. 2012;40:341-9.
• 20. Tuulonen A, Airaksinen PJ. Initial glaucomatous optic disk and retinal nevre fiber layer abnormalities and their progression. Am J Ophtalmol. 1999;111:485-90.
• 21. Drance SM. Disc hemorrhages in the glaucomas. Surv Ophthalmol.1989;33:331-7.
• 22. Jonas JB, Naumann GO. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci. 1989;30:919-26.
• 23. Dikici AS, Mihmanli I, Kilic F, et al. In vivo evaluation of the biomechanical properties of optic nerve and peripapillary structures by ultrasonic shear wave elastography in glaucoma. Iran J Radiol. 2016;13: e36849.
• 24. Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C. Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med. 2012;31:281-7.
• 25. Agrawal KK, Sharma DP, Bhargava G, Sanadhya DK. Scleral rigidity in gloucoma, before and during topical antiglaucoma drug therapy. Indian J Ophtalmol. 1991; 39:85-6.
• 26. Detorakis ET, Drakonaki EE, Tsilimbaris MK, Pallikaris IG, Giarmenitis S. Real-Time Ultrasound Elastographic Imaging of Ocular and Periocular Tissues: A Feasibility Study. Ophtalmic Surgery, Lasers, Imaging. 2010; 41:135-41.
• 27. Vural M, Acar D, Toprak U, et al. The evaluation of the retrobulbar orbital fat tissue and optic nevre with strain ratio elastography. Med Ultrason. 2015;1:45-8.
• 28. Detorakis ET, Drakonaki EE, Ginis H, Karyotakis N, Pallikaris IG. Evaluation of iridociliary and lenticular elasticity using shear-wave elastography in rabbit eyes. Acta Medica.2014;57:9-14.
• 29. Hoyt K, Hah Z, Hazard C, Parker KJ. Experimental validation of acoustic radiation force induced shear wave interference patterns. Phys Med Biol. 2012;57:21-30.
• 30. Arda K, Ciledag N, Aktas E, Aribas BK, Köse K. Quantitative assessment of normal soft-tissue elasticity using shear-wave ultrasound elastography. AJR 2011; 197: 532-6.
• 31. Quigley HA. Glaucoma: macrocosm to microcosm the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2005;46: 2662-70.
• 32. Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol.2012;96:614-8.
• 33. Pekel G, Agladıoglu K, Acer S, Yagcı R, Kasıkcı A. Evaluation of ocular and periocular elasticity after panretinal photocoagulation: an ultrasonic elastography study. Curr Eye Res. 2015;40:332-7.
• 34. Agladioglu K, Pekel G, Altintas Kasikci S, Yagci R, Kiroglu Y. An evaluation of ocular elasticity using real-time ultrasound elastography in primary open-angle glaucoma. Br J Radiol. 2016;89:20150429.
• 35. Unal O, Cay N, Yulek F, Taslipinar AG, Bozkurt S, Gumus M. Real-time ultrasound elastographic features of primary open angle glaucoma. Ultrasound Q. 2016;32:333-7.