SERUM ANJİYOPOİETİN BENZERİ PROTEİN 8 DÜZEYLERİ İLE HİPERTANSİYON EVRELERİ ARASINDAKİ İLİŞKİ

Year 2024, Volume: 25 Issue: 4, 413 - 419, 21.10.2024

Güney Sarıoğlu , İbrahim Aktaş

https://doi.org/10.18229/kocatepetip.1419363

Abstract

AMAÇ: Hipertansiyon ciddi komplikasyonlara yol açabilen ciddi bir durumdur. Günümüzde, hipertansiyon tanısı koymak ve hastalığı evrelemek için klinik uygulamada kullanılan standart bir biyobelirteç yoktur. Bu çalışmanın amacı, anjiyopoietin benzeri protein 8'in (sANGPTL8) serum düzeylerinin hipertansiyon hastalarında ve hipertansiyonun ileri evrelerinde değişip değişmediğini araştırmaktır.
GEREÇ VE YÖNTEM: Çalışmamız, prospektif gözlemsel bir çalışmadır. Kardiyoloji polikliniğimizde, 42 hipertansif ve 41 hipertansif olmayan sağlıklı hastada, sANGPTL8 düzeylerini ölçmek için bir ELISA kiti kullandık ve gruplar arasındaki istatistiksel farklılıkları değerlendirdik. Two-tailed p< 0.05 değerini istatistiksel olarak anlamlı kabul ettik.
BULGULAR: Evre 2 hipertansiyon grubundaki ortalama sANGPTL8 düzeyleri, evre 1 ve hipertansif olmayan gruba göre istatistiksel olarak anlamlı derecede yüksek olarak tespit edildi (sırasıyla, 813 pg/ml, 524.89 pg/ml ve 518.07 pg/ml) (p= 0.001).
SONUÇ: Çalışmamız, evre 2 hipertansif hastalarda ortalama sANGPTL8 düzeylerinin, evre 1 hipertansif ve normotansif bireylerden daha yüksek olduğunu göstermiştir (p= 0.001). ANGPTL8 ile birlikte kullanılabilecek ek biyobelirteçler ve ANGPTL8 üzerine yapılacak daha fazla araştırma, bu adipokinin ileri evre hipertansiyon tanısında etkili bir biyobelirteç olarak kullanılmasını sağlayabilir.

Keywords

Hipertansiyon, Anjiyopoietin benzeri protein 8, Kan basıncı, Son organ hasarı.

THE RELATIONSHIP BETWEEN SERUM ANGIOPOIETIN-LIKE PROTEIN 8 LEVELS AND HYPERTENSION STAGES

Abstract

OBJECTIVE: Hypertension is a serious condition that can lead to serious complications. Currently, there is no standard biomarker used in clinical practice to diagnose hypertension and stage the disease. The aim of this study was to investigate whether serum levels of angiopoietin-like protein 8 (sANGPTL8) change in hypertensive patients and advanced stages of hypertension.
MATERIAL AND METHODS: Our study is a prospective observational study. We used an ELISA kit to measure sANGPTL8 levels in 42 hypertensive patients and 41 healthy non-hypertensive patients at our cardiology clinic and evaluated statistical differences between the groups. A two-tailed p< 0.05 was considered statistically significant.
RESULTS: The mean sANGPTL8 levels in the stage 2 hypertension group are statistically significantly higher than in the stage 1 and non-hypertensive group (813 pg/ml vs 524.89 pg/ml and 518.07 pg/ml respectively) (p= 0.001).
CONCLUSIONS: According to our study, mean sANGPTL8 levels were higher in stage 2 hypertensive patients compared to stage 1 hypertensive and normotensive individuals (p=0.001). Additional biomarkers that can be used in combination with ANGPTL8 and further research on ANGPTL8 may enable this adipokine to be used as an effective biomarker in diagnosing advanced hypertension.

Keywords

Hypertension, Angiopoietin-Like Protein 8, Blood Pressure, End-organ damage.

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