COMPARISON OF SELF ESTEEM, ANXIETY AND DEPRESSION WITH CORTISOL/DEHYDROEPIANDROSTERONE SULFATE RATIOS IN HYPOTHYROID

Year 2025, Volume: 26 Issue: 1, 56 - 60, 27.01.2025

Hafize Kızılkaya , Elif Turan , Gurbet Bozkurt , Yeşim Göçmen , Yalcin Aral

https://doi.org/10.18229/kocatepetip.1335749

Abstract

OBJECTIVE: We aim to investigate the relationship self esteem, anxiety and depression with cortisol/dehydroepiandrosterone sulfate (DHEAS) ratios in hypothyroid patients.
MATERIAL AND METHODS: Total of 150 subjects, aged between 18-70 years were included study. Patients were divided into three groups as euthyroid, subclinical hypothyroid and hypothyroid. Fasting blood was drawn to obtain thyroid function, DHEAS and cortisol levels. Each patients filled the Beck Depression Scale, Beck Anxiety Scale and Rosenberg Self-Esteem Scale with the same psychologist.
RESULTS: Cortisol, cortisol/DHEAS ratios, depression and anxiety scores were significantly higher in hypothyroid group. A negative correlation was found between cortisol levels and self-esteem scores (r=-.233, p<.05); TSH levels and anxiety (r=-0.212, p<.05); self respect and anxiety (r=-0.297, p<.05); depression and self respect (r=-0.411, p<.05); depression and cortisol/DHEAS ratio (r=-0.187, p<.05). A positive correlation was found between cortisol and anxiety (r=+0.195, p<.05); cortisol and cortisol/DHEAS ratio (r=+0.533, p<.05), free T3 and self esteem score (r=-.202, p<.05).
CONCLUSIONS: Patients with overt hypothyroidism were associated with low self-esteem, anxiety and depression scores. In addition, a negative correlation was found between depression scores and cortisol/DHEAS ratio.

Keywords

Hypothyroidism, Cortisol, Self-esteem, Anxiety, Depression.

Supporting Institution

Bozok Üniversitesi Tıp Fakültesi, Proje Koordinasyon Uygulama ve Araştırma Merkezi tarafından desteklenmiştir.

Project Number

6601‑TF/16‑34

Thanks

none

HİPOTİROİDİDE, BENLİK SAYGISI, ANKSİYETE VE DEPRESYON İLE KOTİZOL/DEHİDROEPİANDROSTERON SULFAT ORANLARININ KARŞILAŞTIRILMASI

Abstract

AMAÇ: Hipotiroidisi olan hastalarda benlik saygısı, anksiyete ve depresyon ile kortizol/dehidroepiandrosteron sülfat (DHEAS) oranları arasındaki ilişkiyi araştırmayı amaçladık.
GEREÇ VE YÖNTEM: : Çalışmaya 18-70 yaş arası toplam 150 kişi dahil edildi. Hastalar ötiroid, subklinik hipotiroid ve hipotiroid olarak üç gruba ayrıldılar. Tiroid fonksiyonu, DHEAS ve kortizol düzeylerini elde etmek için açlık kanı alındı. Her hasta aynı psikolog tarafından Beck Depresyon Ölçeği, Beck Anksiyete Ölçeği ve Rosenberg Benlik Saygısı Ölçeği'ni doldurdu.
BULGULAR: Kortizol, kortizol/DHEAS oranları, depresyon ve anksiyete puanları hipotiroidi grubunda anlamlı olarak yüksekti. Kortizol düzeyleri ile benlik saygısı puanları arasında (r=-.233, p<.05); TSH düzeyleri ve kaygı (r=-0.212, p<.05) arasında; kendine saygı ve kaygı (r=-0.297, p<.05) arasında; depresyon puanları ve kendine saygı (r=-0.411, p<.05) arasında; depresyon puanları ve kortizol/DHEAS oranı (r=-0.187, p<.05) arasında negatif korelasyon bulundu. Kortizol ile anksiyete puanları arasında (r=+0.195, p<.05); kortizol ve kortizol/DHEAS oranı (r=+0.533, p<.05) arasında ve de serbest T3 ve benlik saygısı puanı (r=+.202, p<.05) arasında ise pozitif kolerasyon bulundu.
SONUÇ: Belirgin hipotiroidisi olan hastalar düşük benlik saygısı, anksiyete ve depresyon puanları ile ilişkiliydi. Ayrıca depresyon puanları ile kortizol/DHEAS oranıyla negatif korelasyon bulundu.

Keywords

hipotiroidi, kortizol, DHEAS, Benlik saygısı

Project Number

6601‑TF/16‑34

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