The Comparison of the Effects of the Cilostazol on the Stiffness Parameters in Different Arterial Systems in the Patients with Peripheral Arterial Disease

Year 2016, Volume: 11 Issue: 3, 11 - 16, 24.03.2017

Murat Baykara , Özlem Gündoğdu Seçen

https://doi.org/10.17517/ksutfd.297667

Abstract

Objective: Object of this study is to determine the effect of cilostazol on
arterial compliance, distensibilty and vascular stiffness in carotid, femoral and brachial arteries through non-invasive methods in patients with
stable IC/PAD.
Material and Methods: Twenty-nine patients (22 male, 7 female) who
had been treated with cilostazol 100 mg twice daily during six month
were included in the study. Ultrasound measurements of carotid, femoral and brachial arteries were performed at baseline, at 3 and 6 months
afer starting of treatment and the evaluation of the arterial stiffness
measurements were performed by the pre-defned method.
Results: Te mean age of the participants was 64 years. Pulsatility index, resistive index, systolic/diastolic velocity ratio, intima-media thickness and elastic modulus values were decreased while cross-sectional
compliance, cross-sectional distensibility and diastolic wall stress values
were increased with treatment in carotid, femoral and brachial arteries.
Carotid, femoral and brachial arteries have similar rates of change.
Conclusion: Cilostazol treatment reduced the progression of atherosclerosis without increasing the risk of bleeding in patients with peripheral arterial disease during a long-term follow-up  

Keywords

Peripheral arterial disease, stiffness, Cilostazol

References

• Robless P, Mikhailidis DP, Stansby GP. Cilostazol