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Effect of Intranasal Salbutamol on the Nose Obstruction Seen in Pediatric Patients with Allergic Rhinitis

Year 2019, Volume: 14 Issue: 2, 66 - 68, 15.07.2019
https://doi.org/10.17517/ksutfd.480722

Abstract

Objective: To investigate whether
intranasal salbutamol has efficacy in pediatric patients with allergic rhinitis
with atopy.

Material and Methods:  Sixteen pediatric
patients (9 boy, 6 girl) with allergic rhinitis with atopy within age between 6
and 17 years were administered intranasal salbutamol and evaluated with
acoustic rhinometry before and just after the 
administration of the drug.

Results: There was a
statistically significant difference between CSA1 SD in both left and right
nasal cavities, and also in CSA1 area, CSA3 distance in right nasal cavity
before and after salbutamol administration.







Conclusion: Intranasal salbutamol
administration is effective in pediatric patients with allergic rhinitis with
atopy without side effect. Also intranasal salbutamol may be used as a rescue
medicine in acute nasal obstructions.

References

  • Blaiss MS. Pediatric allergic rhinitis: Physical and mental complications. Allergy Asthma Proc 2008: 29(1): 1-6.
  • Corey JP. Acoustic Rhinometry: Should we be using it? Curr Opin Otolaryngol Head Neck Surg 2006: 14: 29-34.
  • Slavin RG. The upper and lower airways: The epidemiological and pathophysiological connection. Allergy Asthma Proc 2008: 29: 553-556.
  • Aas K. Some variables in skin prick testing. Allergy 1980: 35: 250-2.
  • Proud D, Reynolds CJ, Lichtenstein LM, Kagey-Sobotka A, Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998: 28(7): 868-75.
  • Schmidt WF, Waters RM, Mitchell AD, Warthen JD, Honigberg Jr IL, Van Halbeek H. Int J Pept Protein Res 1993: 41(5): 467-75.
  • Wecksler N, Brill S, Tarnapolski A, Gurman GM. Intranasal salbutamol instillation in asthma attack. Am J Emerg Med 1999: 17(7): 686-8.
  • Hussain AA, Dakkuri A, Lai YL, Traboulsi A, Hussain MA. Nasal administration of albuterol: an alternative route of delivery. J Pharm Pharmacol 2004: 56(10): 1211-5.
  • Hussain AA, Diamond L, Thompson D, Latta J, Dittert LW. Intranasal administration of a beta adrenergic amine: an alternative to metered dose inhalers. Ann Allergy 1992: 69(1): 26-9.
  • Tay HL, Armoogum N, Tan LK. Nasal mucociliary clearance and salmeterol. Clin Otolaryngol Allied Sci 1997: 22(1): 68-70.
  • Roberts DN, Birchall MA, East CA, Scadding G. Inranasal salbutamol has no effect on mucociliary clearance in normal subjects. Clin Otolaryngol Allied Sci 1995: 20(3): 246-8.
  • Stewart EJ, Cinnamond MJ, Nicholls P, Stanford CF. The influence of beta-adrenoceptors on nasal mucosal function. Rhinology 1993: 31(3): 121-4.
  • Russo C, Zeng D, Prosperini G, Spicuzza L, Guarino F, Polosa R. Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5’ monophosphate nasal challenge. Clin Exp Allergy 2005: 35(9): 1192-6.
  • Di Lorenzo G, Morici G, Norrito F, Mansueto P, Melluso M, Purello D’Ambrosio et al. Comparison of the effects of salmeterol and salbutamol on clinical activity and eosinophil cationic protein serum levels during the polen season in atopic asthmatics. Clin Exp Allergy 1995: 25(10): 951-6.
  • Piatti G, Ambrosetti U, Santus P, Allegra L. Effects of salmeterol on cilia and mucus in COPD and pneumonia patients. Pharmacol Res 2005: 51(2): 165-8.

İntranazal Salbutamolün Allerjik Rinitli Çocuk Hastalarda Görülen Burun Tıkanıklığı Üzerine Etkisi

Year 2019, Volume: 14 Issue: 2, 66 - 68, 15.07.2019
https://doi.org/10.17517/ksutfd.480722

Abstract



Amaç: Atopik alerjik rinitli
çocuk hastalarda intranazal salbutamol uygulanmasının etkisi olup olmadığını
araştırmak.

Gereç ve Yöntemler:
Yaşları 6 ile 17 arasında atopik alerjik rinitli on altı çocuk hastaya (9
erkek, 7 kız) intranazal salbutamol uygulandı 
ve ilaç uygulamasından önce ve hemen sonra akustik rinometri ile
değerlendirildi.

Bulgular: İntranazal salbutamol
uygulamasından önce ve sonra sol ve sağ nazal kaviteler arasında CSA(Çapraz
kesit alanı)1 SD(standart deviasyon) ve ayrıca sağ nazal kavitede CSA1 alanı ve
CSA3 mesafesi arasında istatistiksel olarak anlamlı fark vardı.







Sonuç: İntranazal salbutamol
uygulaması atopik alerjik rinitli çocuk hastalarda hiçbir yan etkisi olmaksızın
faydalıdır. Ayrıca intranazal salbutamol akut burun tıkanıklıklarında kurtarıcı
ilaç olarak kullanılabilir. 

References

  • Blaiss MS. Pediatric allergic rhinitis: Physical and mental complications. Allergy Asthma Proc 2008: 29(1): 1-6.
  • Corey JP. Acoustic Rhinometry: Should we be using it? Curr Opin Otolaryngol Head Neck Surg 2006: 14: 29-34.
  • Slavin RG. The upper and lower airways: The epidemiological and pathophysiological connection. Allergy Asthma Proc 2008: 29: 553-556.
  • Aas K. Some variables in skin prick testing. Allergy 1980: 35: 250-2.
  • Proud D, Reynolds CJ, Lichtenstein LM, Kagey-Sobotka A, Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998: 28(7): 868-75.
  • Schmidt WF, Waters RM, Mitchell AD, Warthen JD, Honigberg Jr IL, Van Halbeek H. Int J Pept Protein Res 1993: 41(5): 467-75.
  • Wecksler N, Brill S, Tarnapolski A, Gurman GM. Intranasal salbutamol instillation in asthma attack. Am J Emerg Med 1999: 17(7): 686-8.
  • Hussain AA, Dakkuri A, Lai YL, Traboulsi A, Hussain MA. Nasal administration of albuterol: an alternative route of delivery. J Pharm Pharmacol 2004: 56(10): 1211-5.
  • Hussain AA, Diamond L, Thompson D, Latta J, Dittert LW. Intranasal administration of a beta adrenergic amine: an alternative to metered dose inhalers. Ann Allergy 1992: 69(1): 26-9.
  • Tay HL, Armoogum N, Tan LK. Nasal mucociliary clearance and salmeterol. Clin Otolaryngol Allied Sci 1997: 22(1): 68-70.
  • Roberts DN, Birchall MA, East CA, Scadding G. Inranasal salbutamol has no effect on mucociliary clearance in normal subjects. Clin Otolaryngol Allied Sci 1995: 20(3): 246-8.
  • Stewart EJ, Cinnamond MJ, Nicholls P, Stanford CF. The influence of beta-adrenoceptors on nasal mucosal function. Rhinology 1993: 31(3): 121-4.
  • Russo C, Zeng D, Prosperini G, Spicuzza L, Guarino F, Polosa R. Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5’ monophosphate nasal challenge. Clin Exp Allergy 2005: 35(9): 1192-6.
  • Di Lorenzo G, Morici G, Norrito F, Mansueto P, Melluso M, Purello D’Ambrosio et al. Comparison of the effects of salmeterol and salbutamol on clinical activity and eosinophil cationic protein serum levels during the polen season in atopic asthmatics. Clin Exp Allergy 1995: 25(10): 951-6.
  • Piatti G, Ambrosetti U, Santus P, Allegra L. Effects of salmeterol on cilia and mucus in COPD and pneumonia patients. Pharmacol Res 2005: 51(2): 165-8.
There are 15 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Sıdıka Deniz Yalım 0000-0001-7833-8421

Suna Asilsoy

İsmail Yılmaz This is me

Cemile Durmaz This is me

Belgin Usta Güç This is me

Publication Date July 15, 2019
Submission Date November 8, 2018
Acceptance Date January 16, 2019
Published in Issue Year 2019 Volume: 14 Issue: 2

Cite

AMA Yalım SD, Asilsoy S, Yılmaz İ, Durmaz C, Usta Güç B. İntranazal Salbutamolün Allerjik Rinitli Çocuk Hastalarda Görülen Burun Tıkanıklığı Üzerine Etkisi. KSU Medical Journal. July 2019;14(2):66-68. doi:10.17517/ksutfd.480722