Relation of Disease Severity with Neutrophil Lymphocyte Ratio and Mean Platelet Volume in Rheumatoid Arthritis

Year 2019, Volume: 14 Issue: 3, 105 - 109, 15.11.2019

Gökhan Aytekin , İbrahim Akdağ

https://doi.org/10.17517/ksutfd.512962

Abstract

Objective: Rheumatoid
arthritis (RA) is a systemic inflammatory disease characterized by symmetrical
erosive synovitis. The neutrophil to lymphocyte ratio (NLR) and mean platelet
volume (MPV) have been widely used to determine the severity of inflammation.
Objectives: We aimed to investigate NLR and MPV values in RA population further
assessing the relation between these indices, inflammatory markers and disease
activity scores.

Material and Methods: The present study
was performed between March 2012 and March 2013, and designed retrospectively.
Total 156 patients of RA were included.

 Results:
The NLR was higher in active disease group but there was not significant
difference between the remission group and active disease group (p: 0.616).
Also NLR of low disease activity group, moderate disease activity group and
high disease activity group were 1.98±0.71, 2.26±1.04, and 3.11±2.16
respectively. There is significant difference between groups (p: 0.030). The
MPV of remission group and active disease group were 8.54±0.78 fl and 8.89±0.99
fl, respectively and there is no significant difference between both groups (p:
0.126). Also the MPV of remission group, low disease activity group, moderate
disease activity group and high disease activity group were 9.31±1.09 fl,
8.91±0.98 fl, 8.71±0.97 fl, respectively. Although MPV is reduced in patients
with higher disease activity, it was found that there was no significant
difference between the groups (p: 0.206).

Conclusions: NLR can be a useful
marker to assess disease activity in RA patients. Increased NLR values ​​may
indicate increased disease activity. Whereas, there is a need for comprehensive
studies to claim that average platelet volume as an indicator of disease
severity in RA patients.

Keywords

Neutrophil Lymphocyte Ratio, Mean Platelet Volume, Rheumatoid Arthritis

Romatoit Artritte Hastalık Aktivitesinin Nötrofil lenfosit Oranı ve Ortalama Trombosit Hacmi ile İlişkisi

Abstract

Amaç: Romatoid Artrit
(RA), simetrik eroziv sinovit ile karakterize, kronik sistemik inflamatuvar bir
hastalıktır. Nötrofil lenfosit oranı (NLO) ve ortalama trombosit hacmi (OTH)
ise inflamasyonun şiddetini belirlemek için kullanılan yeni belirteçlerdir. Biz
bu çalışma ile RA'de hastalık aktivitesi ile NLO ve OTH değerleri arasındaki
ilişkiyi ortaya koymayı amaçladık.

Gereç ve Yöntemler: Bu retrospektif
çalışma Mart 2012 ile Mart 2013 arasında yapıldı. Çalışmaya toplam 156 RA
hastası dahil edildi.

Bulgular: NLO aktif hastalık
grubunda remisyon grubuna göre daha yüksekti, ancak remisyon grubu ile aktif
hastalık grubu arasında anlamlı fark yoktu (p: 0.616). Düşük hastalık
aktivitesi grubunda, orta derecede hastalık aktivitesi grubunda ve yüksek
hastalık aktivite grubunda NLO sırasıyla 1.98 ± 0.71, 2.26 ± 1.04 ve 3.11 ±
2.16 idi. Karşılaştırılan gruplar arasında istatiksel olarak anlamlı fark
mevcuttu (p: 0.030). Remisyon grubu ve aktif hastalık grubunun OTH değerleri
sırasıyla 8.54 ± 0.78 ve 8.89 ± 0.99 fl idi ve gruplar arasında anlamlı fark
yoktu (p: 0.126). Ayrıca remisyon grubu, düşük hastalık aktivite grubu, orta
hastalık aktivite grubu ve yüksek hastalık aktivite grubunda OTH sırasıyla 9.31
± 1.09, 8.91 ± 0.98, 8.71 ± 0.97 fl idi. Daha yüksek hastalık aktivitesi olan
hastalarda OTH azalmasına rağmen, gruplar arasında anlamlı fark mevcut değildi
(p: 0.206).

Sonuç: NLO, RA
hastalarında hastalık aktivitesini değerlendirmek için faydalı bir belirteçtir.
Artan NLO değerleri artmış hastalık aktivitesine işaret eder. Fakat OTH
değerlerinin RA hastalarında hastalık aktivite göstergesi olarak
kullanılabilmesi için daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

Nötrofil lenfosit Oranı, Ortalama Trombosit Hacmi, Romatoit Artrit

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