Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value

Year 2022, Volume: 17 Issue: 1, 121 - 129, 21.03.2022

Didar Gürsoy , İclal Gürses , Vedia Bennu Gilan , Bahar Taşdelen , Ali Arıcan , Celalettin Tok

https://doi.org/10.17517/ksutfd.873338

Abstract

Our study aimed to determine immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 genes and their relationship with clinicopathological features and prognostic significance. The present study included 85 patients that were diagnosed with epithelial OC, treated and followed-up between 2002 and 2012 at Mersin University, Faculty of Medicine. Immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 and their relation-ship with clinicopathological parameters were evaluated. In serous carcinomas, expression of ER was significantly associated with metastasis to the fallopian tube, expression of PR was significantly associated with patient’s age, expression of p53 was significantly associated with the progression-free survival (PFS), cytoplasmic expression of BRCA1 was significantly associated with the overall survival (OS) and PFS. In pathogenesis groups, 55 tumors were type 1, and 30 tumors were type 2. There were significant correlations with ER, PR and p53 expressions between the two groups. In our study, PR and p53 were prognostic factors in serous carcinoma. Extensive studies that contain more cases in each histological group are needed to determine the prognostic value of these five immunohistochemical markers.

Keywords

ovarian cancer, hormone receptors, C-erb-B2, P53, BRCA1

Supporting Institution

Mersin Üniversitesi, BAP bİRİMİ

Project Number

BAP-TF CTB (DG) 2013-3 TU.

Thanks

We would present our thanks to Assistant Professor M. D. Huseyin Durukan from Mersin University, Department of Obstetrics and Gynecology for his precious contribution to our study.

Over Karsinomlarında Östrojen, Progesteron Reseptörleri, C-Erb B-2, P53 ve BRCA1’in İmmünhistokimyasal Ekspresyonu ve Prognostik Önemleri

Abstract

Çalışmamız ER, PR, C-erbB-2, p53 ve BRCA1 genlerinin immünohistokimyasal ekspresyonunu ve bunların klinikopatolojik özellikler ve prognostik önemi ile ilişkisini belirlemeyi amaçlamaktadır. Çalışmamıza Mersin Üniversitesi Tıp Fakültesi'nde 2002-2012 yılları arasında epitelyal OK tanısı konulan ve takip edilen 85 hasta dahil edildi. ER, PR, C-erbB-2, p53 ve BRCA1'in immünohistokimyasal ekspresyonu ve bunların klinikopatolojik parametrelerle ilişkisi değerlendirildi. Seröz karsinomlarda, ER ekspresyonu fallop tüpüne metastaz ile, PR ekspresyonu hastanın yaşı ile anlamlı şekilde ilişkiliydi, p53 ekspresyonu progresyonsuz sağkalım (PFS) ile anlamlı şekilde ilişkilendirildi, BRCA1'in sitoplazmik ekspresyonu genel sağkalım (OS) ve PFS ile anlamlı şekilde ilişkiliydi. Patogenez gruplarında 55 tümör tip 1 ve 30 tümör tip 2 idi. İki grup arasında ER, PR ve p53 ekspresyonları ile anlamlı korelasyonlar vardı. Çalışmamızda PR ve p53 seröz karsinomda prognostik faktörlerdi. Bu beş immünohistokimyasal belirtecin prognostik değerini belirlemek için her histolojik grupta daha fazla vaka içeren kapsamlı çalışmalara ihtiyaç vardır.

Keywords

ovarian cancer, hormone receptors, C-erb-B2, P53, BRCA1

Project Number

BAP-TF CTB (DG) 2013-3 TU.

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