Obezitede İnflamasyon ve İnsülin Direncine Etkili Hematolojik ve İnflamatuar Parametreler

Year 2023, Volume: 18 Issue: 2, 39 - 44, 12.07.2023

Orkun Sarıçam

https://doi.org/10.17517/ksutfd.1114938

Cited By: 1

Abstract

Amaç: Obezite; insülin direnci, tip 2 diyabet ve pek çok metabolik sendromun altında yatan baskın risk faktörlerinden biridir. Bu çalışmada obez hastalarda
inflamasyon parametrelerini, bu parametrelerin insülin direnci (İD) ve kan grupları ile ilişkisi araştırmayı amaçladık.
Gereç ve Yöntemler: Hasta ve kontrol grubunun demografik özellikleri, vücut kitle indeksleri (VKİ), biyokimya, hemogram, C-reaktif proteinin (CRP) ve
kan grupları kayıt edilerek gruplar arasında karşılaştırıldı.
Bulgular: Obez hastaların yaş ortalaması 37.37±11.43 yıldı ve %41.8’inde (n=77) insülin direnci vardı. Obez ve İD olan grubun nötrofil ve monosit düzeyleri
İD olmayan kontrol ve obez gruplardan anlamlı derecede yüksekti (p<0.001). İD olan obezlerde nötrofil/lenfosit oranı (NLO), monosit/HDL oranı
(MHO) ve sistemik immün-inflamatuar indeks (Sİİ) düzeyleri İD olamayan obezlerden anlamlı derecede yüksekti. B kan grubunda olan obezlerde İD ve
nötrofil oranları O kan grubundakilere göre anlamlı derecede yüksek bulundu (p=0.023).
Sonuç: Obez ve İD olan grupta hematolojik inflamatuar parametreleri ve NLO, MHO ve Sİİ gibi sistemik kronik inflamasyonu gösteren oranları yüksek
bulduk. Çalışmamızın artmış yağ dokusunun neden olduğu inflamasyon ve obezlerde İD gelişimi arasındaki ilişkiyi gösterdiğini, gelecekte bu konuda yapılacak
çalışmaların erken teşhis ve tedavilerin tasarlanmasında yardımcı olacağını düşünüyoruz

Keywords

Obezite, İnsülin resistansı, İnflamasyon, Kan grubu.

Supporting Institution

yok

Hematological and Inflammatory Parameters Effective on Inflammation and Insulin Resistance in Obesity

Abstract

Objective: Obesity is one of the predominant risk factors associated with insulin resistance (IR), type 2 diabetes, and many metabolic syndromes. In this
study, we aimed to investigate inflammatory parameters and their relationship with IR and blood groups in obese individuals.
Materials and Methods: The demographic characteristics, body mass index (BMI), biochemical parameters, hemogram values, and blood group types of
individuals in the obesity and control groups were recorded and compared.
Results: The mean age was 37.37±11.43 years in obese individuals and 41.8% (n=77) of them had IR. Neutrophil and monocyte counts of the obese individuals
with IR were significantly higher than those of the individuals without IR in the control and the obesity groups (p<0.001). The neutrophil/lymphocyte
ratio (NLR), the monocyte/high-density lipoprotein cholesterol ratio (MHR), and the systemic immune-inflammation index (SII) were significantly higher
in obese individuals with IR compared to obese individuals without IR. IR was more common and neutrophil ratios were significantly higher in obese individuals
with B blood type compared to those with O blood type (p=0.023).
Conclusion: We found that the values of hematological inflammatory parameters and the levels of NLR, MHR, and SII as indicators of systemic chronic
inflammation were increased in obese individuals with IR. We think that our study shows the relationship between inflammation due to excess adipose tissue
and the development of IR in obese individuals. We are of the opinion that future studies investigating this subject will help to develop processes for early
diagnosis and treatment.

Keywords

Obesity, Insulin resistance, Inflammation, Blood groups.

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