A Simple MRI-Based Visual Guide To Differentiate Alzheimer’s Disease From Mild Cognitive İmpairment

Year 2023, Volume: 18 Issue: 3, 13 - 16, 20.11.2023

Şeyda Çankaya

https://doi.org/10.17517/ksutfd.1165016

Abstract

Objective: To distinguish between mild cognitive impairment (MCI) and Alzheimer’s disease (AD) by visual assessment of the length of the hippocampus
in magnetic resonance imaging (MRI).
Material and Methods: Consecutive patients diagnosed with MCI and AD were retrospectively searched on the Hospital Information Management Systems. MRI was rated for hippocampal atrophy defining with and without loss of hippocampal length. Patients with loss of hippocampal height were classified
as having AD by the clinical investigator, and the diagnosis of the patients was checked on the system.
Results: A total of 56 memory clinic patients with AD (n=14) and MCI (n=42) were included in the study. AD patients had significantly more hippocampal
atrophy than MCI patients (χ2=6.222, df=0.13, p=0.013).
Conclusion: There is a complex issue in the differential diagnosis between MCI and AD. A simple glace to the MRI may give a brief opinion to the physician in the clinic routine

Keywords

Alzheimer’s disease, mild cognitive impairment, hippocampus, MRI

Alzheimer Hastalığını Hafif Bilişsel Bozukluktan Ayırmak İçin Basit Bir MRI-Tabanlı Görsel Kılavuz

Abstract

Amaç: Bu çalışmada manyetik rezonans görüntülemede (MRI) hipokampus uzunluğunun görsel olarak değerlendirilmesi yoluyla hafif bilişsel bozukluk (HBB) ile Alzheimer hastalığı (AH) arasında ayrım yapmayı amaçladık.
Gereç ve Yöntemler: HBB ve AH tanısı alan hastalar hastane bilgi yönetim sisteminden geriye dönük olarak tarandı. Hipokampus yüksekliğinde azalma olup olmaması ile hipokampal atrofinin tanımlanması MRI ile değerlendirildi. Hipokampusta yükseklik kaybı olan hastalar klinik araştırmacı tarafından AH olarak sınıflandırıldı ve hastaların tanıları sistem üzerinden daha sonra kontrol edildi.
Bulgular: Çalışmaya AH (n=14) ve HBB (n=42) olan toplam 56 hasta dahil edildi. AH hastalarında HBB hastalarından anlamlı olarak daha fazla hipokampal atrofi vardı (χ2=6.222, SD=1, p=0.013).
Sonuç: HBB ve AH arasındaki ayırıcı tanı kompleks bir konudur. MRI’a basit bir bakış, klinik rutinde hekime kısa bir fikir verebilir.

Keywords

hipokampus, Alzheimer hastalığı, hafif bilişsel bozukluk, MRI

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