Review
Year 2017,
Volume: 5 Issue: 2, 30 - 38, 05.02.2017
Abstract
Abstract
Liver is a complex organ with many functions. In liver injuries, the clinical and laboratory spectrum will range from silent laboratory abnormalities to dramatic andrapidly progressive liver failure. Although the etiology of illness and the reserve ofliver are determinant factors; all the liver function tests should be evaluated togetherto diagnose; determine the clinics and prognosis of the illness; since there is no sin-gle test for it.
Keywords
References
- Kaynaklar 1.Lester R, Schmid R. Bilirubin metabolism. N Engl J Med 1964;270:779-86. 2.Lott JA, Wolf PL. Alanine and aspartate aminotransferase(ALT andAST) . Clinical enzymology: a case oriented approach. Chicago, YearBook Medical Publishers, 1986, 111-138. 3.Dong MH, Bettencourt R, Brenner DA, et al. Serum levels of alani-ne aminotransferase decrease with age in longitudinal analysis. ClinGastroenterol Hepatol 2012; 10:285-90 4.Pratt D.S. Liver chemistry and function tests. Sleisenger and Fordt-ran’s Gastrointestinal and liver disease, 10th edition. Page 1243-1253. 5.Cohen JA, Kaplan MM. The SGOT/SGPT ratio: An indicator of al-coholic liver disease. Dig Dis Sci. 1979; 24:835-8. 6.Diehl A, Boitnott J, Van Duyn M, et al. Relationship between pyri-doxal 5’phosphate deficiency and aminotransferase levels in alco-holic hepatitis. Gastroenterology 1984;86:632-6. 7.Nathwani RA, Pais S, Reynolds TB, et al. Serum alanine aminotrans-ferase in skeletal muscle disease. Hepatology 2005; 41:380-382. 8.Giannini E, Botta F, Fasoli A, et al. Progressive liver functional im-pairment is associated with an increase in AST/ALT ratio. Dig DisSci 1999; 44:1249-53. 9.Ersoy O. Karaciğer enzim yüksekliğinin değerlendirilmesi. AnkaraMedical Journal 2012;12(3):129-135. 10.Mete B.Sepsiste böbrek ve karaciğer. İ.Ü. Cerrahpaşa Tıp Fak. Sü-rekli Tıp Eğitimi Etkinlikleri. 2006; 51:35-43. 11.Stevens WE, Patil A. Vascular disease of the liver. Sleisenger andFordtran’s Gastrointestinal and liver disease, 9th edition. Page 1380 12.Henrion J, Schapira M, Luwaert R et al. Hypoxic hepatitis. Clini-cal and hemodynamic study in 142 consecutive cases. Medicine,2003;82:392-406. 13.Uygun A, Polat Z. Viral hepatit dışı serum transaminaz düzeyindeartışa neden olan hastalıklar. Güncel Gastroenteroloji 2009; 13/4:211-224. 14.Tezel A, Dökmeci G, Soylu R. Anormal karaciğer fonksiyon testle-ri olan hastaya yaklaşım. Türk Gastroenteroloji Vakfı. Gastroente-roloji. 2002:421-432. 15.Bayan K, Tuzun Y, Ozcan M, Yılmaz Ş, Turgutalp S. Dubin-Johnsonsendromu tanılı bir olgu nedeniyle konjuge hiperbilirubinemiler. Dic-le Tıp Dergisi. 2008. Cilt 55, sayı:3, 196-200. 16.Karaoğlu AÖ, Topalak ÖS. Familyal non-hemolitik hiperbilirubine-miler. Güncel Gastroenteroloji. 1999, 3/2; 217-224. 17.Einarsson K, Angelin B, Bjorkhem I, et al. The diagnostic value offasting individual serum bile acids in anicteric alcoholic liver disea-se: Relation to liver morphology. Hepatology 1985; 5:108-11. 18.Sahan C. Gebeliğin intrahepatik kolestazı. Güncel Gastroenterolo-ji. Eylül 2004, 8/3, sf:205-211. 19.Ozkan S, Ceylan Y, Ozkan O.V, Yildirim S. Review of challenging is-sue: Intrahepatic cholestasis of pregnancy. World J Gastroenterol2015; 21; 21(23):7134-7141 20.Kaplan M. Serum alkaline phosphatase: Another piece is added tothe puzzle. Hepatology 1986; 6:526. 21.Moussavian S, Becker R, Piepmeyer J, et al. Serum gamma-glutamyltranspeptidase and chronic alcoholism: Influence of alcohol inges-tion and liver disease. Dig Dis Sci 1985; 30:211-14. 22.Yang M, Chen T, Wang S, et al. Biochemical predictors for absen-ce of common bile duct stones in patients undergoing laparoscopiccholecystectomy. Surg Endosc 2008; 22:1620-4. 23.Pinkham CA, Krause KJ. Liver function tests and mortality in a co-hort of life insurance applicants. J Insur Med 2009; 41:170-7. 24.Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel C, BrennerD et all. Serum g-glutamyl transpeptidase predicts all-cause, car-diovasculer and liver mortality in older adults. J Clin Exp Hepatol.2013 Mar, 3(1):4-11. 25.Gezer S. Koagulasyon testlerinin klinikte kullanımı. HematoLog2012:2/2, 8-23.
Year 2017,
Volume: 5 Issue: 2, 30 - 38, 05.02.2017
Abstract
Öz
Karaciğer pek çok fonksiyonu bir arada barındıran, oldukça kompleks yapıda bir organdır. Karaciğer hasarlanmasında, klinik olarak sessiz laboratuvar anomalilerinden dramatik ve hızla ilerleyen karaciğer yetmezliğine uzanan geniş bir klinik ve laboratuvarspektrum saptanabilir. Etioloji ve karaciğer rezervi belirleyici olmakla birlikte; karaciğer hastalıklarının tanısında, seyrini ve prognozunu belirlemede tek başına kullanılabilecek bir testin olmaması nedeni ile karaciğer fonksiyon testlerinin tamamının detaylı bir şekilde değerlendirilmesi gereklidir.
Keywords
References
- Kaynaklar 1.Lester R, Schmid R. Bilirubin metabolism. N Engl J Med 1964;270:779-86. 2.Lott JA, Wolf PL. Alanine and aspartate aminotransferase(ALT andAST) . Clinical enzymology: a case oriented approach. Chicago, YearBook Medical Publishers, 1986, 111-138. 3.Dong MH, Bettencourt R, Brenner DA, et al. Serum levels of alani-ne aminotransferase decrease with age in longitudinal analysis. ClinGastroenterol Hepatol 2012; 10:285-90 4.Pratt D.S. Liver chemistry and function tests. Sleisenger and Fordt-ran’s Gastrointestinal and liver disease, 10th edition. Page 1243-1253. 5.Cohen JA, Kaplan MM. The SGOT/SGPT ratio: An indicator of al-coholic liver disease. Dig Dis Sci. 1979; 24:835-8. 6.Diehl A, Boitnott J, Van Duyn M, et al. Relationship between pyri-doxal 5’phosphate deficiency and aminotransferase levels in alco-holic hepatitis. Gastroenterology 1984;86:632-6. 7.Nathwani RA, Pais S, Reynolds TB, et al. Serum alanine aminotrans-ferase in skeletal muscle disease. Hepatology 2005; 41:380-382. 8.Giannini E, Botta F, Fasoli A, et al. Progressive liver functional im-pairment is associated with an increase in AST/ALT ratio. Dig DisSci 1999; 44:1249-53. 9.Ersoy O. Karaciğer enzim yüksekliğinin değerlendirilmesi. AnkaraMedical Journal 2012;12(3):129-135. 10.Mete B.Sepsiste böbrek ve karaciğer. İ.Ü. Cerrahpaşa Tıp Fak. Sü-rekli Tıp Eğitimi Etkinlikleri. 2006; 51:35-43. 11.Stevens WE, Patil A. Vascular disease of the liver. Sleisenger andFordtran’s Gastrointestinal and liver disease, 9th edition. Page 1380 12.Henrion J, Schapira M, Luwaert R et al. Hypoxic hepatitis. Clini-cal and hemodynamic study in 142 consecutive cases. Medicine,2003;82:392-406. 13.Uygun A, Polat Z. Viral hepatit dışı serum transaminaz düzeyindeartışa neden olan hastalıklar. Güncel Gastroenteroloji 2009; 13/4:211-224. 14.Tezel A, Dökmeci G, Soylu R. Anormal karaciğer fonksiyon testle-ri olan hastaya yaklaşım. Türk Gastroenteroloji Vakfı. Gastroente-roloji. 2002:421-432. 15.Bayan K, Tuzun Y, Ozcan M, Yılmaz Ş, Turgutalp S. Dubin-Johnsonsendromu tanılı bir olgu nedeniyle konjuge hiperbilirubinemiler. Dic-le Tıp Dergisi. 2008. Cilt 55, sayı:3, 196-200. 16.Karaoğlu AÖ, Topalak ÖS. Familyal non-hemolitik hiperbilirubine-miler. Güncel Gastroenteroloji. 1999, 3/2; 217-224. 17.Einarsson K, Angelin B, Bjorkhem I, et al. The diagnostic value offasting individual serum bile acids in anicteric alcoholic liver disea-se: Relation to liver morphology. Hepatology 1985; 5:108-11. 18.Sahan C. Gebeliğin intrahepatik kolestazı. Güncel Gastroenterolo-ji. Eylül 2004, 8/3, sf:205-211. 19.Ozkan S, Ceylan Y, Ozkan O.V, Yildirim S. Review of challenging is-sue: Intrahepatic cholestasis of pregnancy. World J Gastroenterol2015; 21; 21(23):7134-7141 20.Kaplan M. Serum alkaline phosphatase: Another piece is added tothe puzzle. Hepatology 1986; 6:526. 21.Moussavian S, Becker R, Piepmeyer J, et al. Serum gamma-glutamyltranspeptidase and chronic alcoholism: Influence of alcohol inges-tion and liver disease. Dig Dis Sci 1985; 30:211-14. 22.Yang M, Chen T, Wang S, et al. Biochemical predictors for absen-ce of common bile duct stones in patients undergoing laparoscopiccholecystectomy. Surg Endosc 2008; 22:1620-4. 23.Pinkham CA, Krause KJ. Liver function tests and mortality in a co-hort of life insurance applicants. J Insur Med 2009; 41:170-7. 24.Loomba R, Doycheva I, Bettencourt R, Cohen B, Wassel C, BrennerD et all. Serum g-glutamyl transpeptidase predicts all-cause, car-diovasculer and liver mortality in older adults. J Clin Exp Hepatol.2013 Mar, 3(1):4-11. 25.Gezer S. Koagulasyon testlerinin klinikte kullanımı. HematoLog2012:2/2, 8-23.
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Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Makaleler 1 |
| Authors | |
| Publication Date | February 5, 2017 |
| Published in Issue | Year 2017 Volume: 5 Issue: 2 |
