Abstract
Objective: Our study aims to evaluate the nasal mucociliary clearance (NMC) in Covid-19 patients who have been recently diagnosed and not been treated yet and investigate how Covid-19 affects NMC.
Methods: A total of 120 participants, who applied to Düzce Atatürk State Hospital between September and November 2020, were included in our study. 60 of them were the participants, diagnosed with Covid-19. And 60 of them were the control group. The age range was 18 to 66. 60 participants, diagnosed with Covid-19 and not yet treated, were included in our study. Those with taste disorders were excluded from the study. The control group consisted of 60 healthy volunteers. NMC was evaluated using a
saccharin test. The results were compared in the Statistical Package for Social Sciences (SPSS).
Results: The study group, which consisted of 60 Covid-19 participants of whom treatment was not yet started, and the 60-participant healthy control group were evaluated in our study. The average age of the study group was 40,72±12,96 and 39,16 in the control group. The average NMC was 15,95±3,37 in the study group, and 8,38±1,03 in the control group. When evaluated statistically, it was found higher in the
study group (p<0,001).
Conclusions: NMC acts as a barrier for inhaled foreign bodies. It is a non-specific protection system against airborne pathogens. Consequently, NMC extends in Covid- 19 patients.
References
- 1. Bouadma L, Lescure F-X, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis.2020;20:697–706
- 2. Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Heal. 2020;25:278–80
- 3. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020; 288:192–206
- 4. Schipper NGM, Verhoef JC, Merkus FWHM. The Nasal Mucociliary Clearance: Relevance to Nasal Drug Delivery. Pharm Res An Off J Am Assoc Pharm Sci. 2020;8:807–14
- 5. Asai K, Haruna SI, Otori N, Yanagi K, Fukami M, Moriyama H. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope. 2000;110:117–22
- 6. He F, Deng Y, Li W. Coronavirus disease 2019: What we know? J Med Virol. 2020; 92:719–25
- 7. Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - J Am Med Assoc. 2020; 323:1239–42
- 8. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420–2
- 9. Andersen I, Jensen PL, Camner P, Philipson K, Proctor DF. A comparison of nasal and tracheobronchial clearance. Arch Environ Health.1974;29:290–3
- 10. Rutland J, Cole PJ. Non-Invasive Sampling Of Nasal Cilia For Measurement Of Beat Frequency And Study Of Ultrastructure. Lancet. 1980; 316:564–5
- 11. Koparal M, Kurt E, Elif E, Fatih A. Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID ‑ 19 : a cross ‑ sectional study. Eur Arch Oto-Rhino-Laryngology. 2020; 1–6
- 12. Ozturk E, Aslan M, Bayındır T. The effect of COVID-19 on nasal mucociliary clearance. Acta Otolaryngol. 2022;142(3-4):329-32.
- 13. Pezato R, David G, Boggi A, Melo B, Rosalino C, Rodriguez A, et al. Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID‑19 Patients. Indian J Otolaryngol Head Neck Surg. 2023;75:772–76
- 14. Akcan F, Dündar Y, Akcan H, Uluat A, Cebeci D, Ünlü İ. Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency. Eur Arch Oto-Rhino-Laryngology. 2019;0(0):0.
- 15. Kucur C, Ozbay I, Gulcan E, Kulekci S, Aksoy S, Oghan F. Evaluation of nasal mucociliary activity in patients with chronic renal failure. Eur Arch Oto-Rhino-Laryngology. 2016;273:1167–71
- 16. Wanner A. Symposium continued. Allergic mucociliary dysfunction. Laryngoscope. 1983;93:68–70
- 17. Sakakura Y, Ukai K, Majima Y, Murai S, Harada T, Miyoshi Y. Nasal mucociliary clearance under various conditions. Acta Otolaryngol. 1983;96:167–73
- 18. Lale AM, Mason JDT, Jones NS. Mucociliary transport and its assessment: A review. Clin Otolaryngol Allied Sci. 1998; 23:388–96
- 19. Kannan S, Ali PSS, Sheeza A, Hemalatha K. COVID-19 ( Novel Coronavirus 2019 ) – recent trends. 2020;19:2006–11
- 20. Huang C, Wang Y, Li X, Ren L, Zhao J, Huet Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506
- 21. Petrov V V. Age features of mucociliary system the mucous membrane of the nasal cavity of the human. Adv Gerontol = Uspekhi Gerontol. 2016;29(3):507-10
- 22. Petrov V V. Age-related changes of hemodynamic potential of the nasal cavity of a human. Adv Gerontol = Uspekhi Gerontol. 2016;29(4):624-7.
- 23. Heidari F, Karimi E, Firouzifar M, Khamushian P, Ansari R, Ardehali MM et al. Anosmia as a prominent symptom of COVID-19 infection. Rhinology. 2020;58:302–3
Abstract
Amaç: Çalışmamızın amacı yeni tanı almış ve henüz tedavi başlanmamış COVİD 19 hastalarında nasal mucocilier klirensi (NMC) değerlendirerek covid 19 un NMC yi nasıl etkilediğini araştırmaktır. Gereç ve Yöntem: Çalışmamıza Düzce Atatürk Devlet Hastanesine 2020 yılı eylülkasım ayları arasında başvuran toplam 120 kişi alındı. Bunların 60 tanesi covid 19 tanısı almış hastalardı. 60 tanesi de kontrol grubuydu. Yaş aralığı 18-66 ydı. Çalışmamıza covid 19 tanısı almış ve tedavi başlanmamış 60 kişi alındı. Tat bozukluğu olanlar çalışmaya alınmadı. Kontrol grubu olarak ta 60 sağlıklı gönüllü alındı. NMC sakkarin test ile değerlendirildi. Sonuçlar Statistical Package for Social Sciences (SPSS) te karşılaştırıldı. Bulgular: Çalışmamızda 60 Covid 19 tanısı alan ve tedavi başlanmamış çalışma grubu ve 60 sağlıklı kontrol grubu değerlendirildi. Yaş ortalaması çalışma grubunda 40,72±12,96 kontrol grubunda 39,16 idi Ortalama NMC çalışma grubunda 15,95±3,37idi, kontrol grubunda ise 8,38±1,03 idi. İstatiksel olarak değerlendirildiğinde çalışma grubunda daha yüksek bulundu (p<0,001). Sonuç: Sonuç olarak NMC Covid 19+ hastalarında uzamaktadır
References
- 1. Bouadma L, Lescure F-X, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis.2020;20:697–706
- 2. Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Heal. 2020;25:278–80
- 3. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020; 288:192–206
- 4. Schipper NGM, Verhoef JC, Merkus FWHM. The Nasal Mucociliary Clearance: Relevance to Nasal Drug Delivery. Pharm Res An Off J Am Assoc Pharm Sci. 2020;8:807–14
- 5. Asai K, Haruna SI, Otori N, Yanagi K, Fukami M, Moriyama H. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope. 2000;110:117–22
- 6. He F, Deng Y, Li W. Coronavirus disease 2019: What we know? J Med Virol. 2020; 92:719–25
- 7. Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - J Am Med Assoc. 2020; 323:1239–42
- 8. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420–2
- 9. Andersen I, Jensen PL, Camner P, Philipson K, Proctor DF. A comparison of nasal and tracheobronchial clearance. Arch Environ Health.1974;29:290–3
- 10. Rutland J, Cole PJ. Non-Invasive Sampling Of Nasal Cilia For Measurement Of Beat Frequency And Study Of Ultrastructure. Lancet. 1980; 316:564–5
- 11. Koparal M, Kurt E, Elif E, Fatih A. Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID ‑ 19 : a cross ‑ sectional study. Eur Arch Oto-Rhino-Laryngology. 2020; 1–6
- 12. Ozturk E, Aslan M, Bayındır T. The effect of COVID-19 on nasal mucociliary clearance. Acta Otolaryngol. 2022;142(3-4):329-32.
- 13. Pezato R, David G, Boggi A, Melo B, Rosalino C, Rodriguez A, et al. Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID‑19 Patients. Indian J Otolaryngol Head Neck Surg. 2023;75:772–76
- 14. Akcan F, Dündar Y, Akcan H, Uluat A, Cebeci D, Ünlü İ. Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency. Eur Arch Oto-Rhino-Laryngology. 2019;0(0):0.
- 15. Kucur C, Ozbay I, Gulcan E, Kulekci S, Aksoy S, Oghan F. Evaluation of nasal mucociliary activity in patients with chronic renal failure. Eur Arch Oto-Rhino-Laryngology. 2016;273:1167–71
- 16. Wanner A. Symposium continued. Allergic mucociliary dysfunction. Laryngoscope. 1983;93:68–70
- 17. Sakakura Y, Ukai K, Majima Y, Murai S, Harada T, Miyoshi Y. Nasal mucociliary clearance under various conditions. Acta Otolaryngol. 1983;96:167–73
- 18. Lale AM, Mason JDT, Jones NS. Mucociliary transport and its assessment: A review. Clin Otolaryngol Allied Sci. 1998; 23:388–96
- 19. Kannan S, Ali PSS, Sheeza A, Hemalatha K. COVID-19 ( Novel Coronavirus 2019 ) – recent trends. 2020;19:2006–11
- 20. Huang C, Wang Y, Li X, Ren L, Zhao J, Huet Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506
- 21. Petrov V V. Age features of mucociliary system the mucous membrane of the nasal cavity of the human. Adv Gerontol = Uspekhi Gerontol. 2016;29(3):507-10
- 22. Petrov V V. Age-related changes of hemodynamic potential of the nasal cavity of a human. Adv Gerontol = Uspekhi Gerontol. 2016;29(4):624-7.
- 23. Heidari F, Karimi E, Firouzifar M, Khamushian P, Ansari R, Ardehali MM et al. Anosmia as a prominent symptom of COVID-19 infection. Rhinology. 2020;58:302–3
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | October 20, 2023 |
| Acceptance Date | September 12, 2023 |
| Published in Issue | Year 2023 |