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Year 2014, , 32 - 36, 01.04.2014

Tanboğa B Mehmet Ali Akkuş

https://doi.org/10.18521/ktd.99634

Abstract

Purpose: In this study, the effect of copper, zinc, copper/zinc and ceruloplasmin ratios on prognosis is examined on a patient group with colorectal cancer. Method: This study is planned as a prospective, cross-sectional case control study. At the general surgery policlinics of ministry of health Ankara education and research hospital between the dates July 2006-April 2007, 35 patients are involved in the study who are identified with colorectal cancer diagnostics. These patients are between the ages of 25-75 (with average of 57), 22 male and 13 female. As the control group, 20 (11 male, 9 female) healthy people without any clinical complaints and laboratory symptoms between the ages 25-64 (with average of 49) are selected among hospital personnel. Copper and zinc levels in blood are observed with samples taken at preoperative phase for the patient group, and at a random time for the control group. Results: Tumor localizations for male patients were 29% at rectum, 34% at other parts of the colon; and for women patients were 13% at rectum and 14% at other parts of the colon. A significant relation is detected between tumor phase and serum copper (p=0.001) and zinc (p=0.001) levels. A significant relation is detected between advanced tumor phase and serum ceruloplasmin and serum copper/zinc ratios (p=0.001). A distinctive decrease in serum zinc level is observed in patient group. Conclusion: The contribution of our study to the literature is, we show that in addition to the parameters like CEA15.5, CEA 19.9, Ca 50, ferritine that are used for tumor markers, the elements like copper, zinc can be used not only as a single parameter, but also separately as copper, zinc, ceruloplasmin and Cu/Zn ratios for evaluation. We think that using these ratios together for evaluation provides more valuable data for early diagnostic, determination of effectiveness for the treatment and determination of prognosis

Keywords

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References

  • Thomson DM, Krupey J, Freedman SO, Gold P. The radioimmunassay of circulating carcinoembriyojenic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969;64(1):161-7. 2. Yaşar M, Kayıkçı A. Kolonoskopi Sonuçlarımızın Retrospektif Analizi [Retrospective Evaluation of Colonoscopy Results]. Konuralp Tıp Dergisi 2010;2(3):6-9.
  • Burtis C, Ashwood AR. Tietz Textbook of Clinical Chemistry, 2nd ed,. Philadelphia: WB Saunders Company, 1994;897-920.
  • Waldmann TA, Hebernan RH. Tumor markers in Diagnosis and Monitoring Therapy. In: Holland JF, Feri E, eds. Cancer Medicine, Philadelphia: Lea Febiger, 1982:1086-9.
  • Piccinini L, Borella P, Bargellini A, Zoboli A: A case-control study on selenium zinc and copper in plasma and hair of subjects affected by breast and lung cancer. Biol Trace Elem Res 1996:51(l): 23-30.
  • Jayadeep A, Raveendran PK, Kannan S, et al. Serum level of copper, zinc, iron and ceruplasmin in oral leukoplakia and squamous celi carcinoma. Exp Clin Cancer Res 1997;16(3): 295-300.
  • Janssen AM, Bosman CB, Kruidenier L, et al. Superoxide dismutases in the human colorectal cancer sequence. Res Clin Oncol 1999;125(6): 327-35
  • Magalova T, Bela V, Brtkova A, Beno L, Kudlackova M, Volkovova K. Copper, zinc and superoxide dismutase in precancerous, benign diseases and gastric, colorectal and breast cancer. Neoplasma 1999; 46(2):100-4.
  • Zowczak M, Iskra M, Torlinski L, Cofta S. Analysis of serum copper and zinc concentrations in cancer patients. Biol Trace Elem Res 2001;82(l-3): l-8.
  • Bessmel'tsev SS, Rybakova LP, Gritskevich NL, Golota GZ, Blinov MN, Abdulkadyrov KM. Diagnostic and prognostic significance of blood-serum ceruloplasmin, acetylcholinesterase and total proteolytic activity in patients with multiple myeloma. Vopr Onkol 1999;45(4): 398-404.
  • Burtis CA, Ashwood ER. Tietz textbook of clinical chemistry, 3rd ed. Philadelphia: WB Saunders, 1999; 490:1016-41.
  • Sharma K, Piccinini L, Mittal DK, Kesarwani RC, Kamboj VP, Chovvdhery. Diagnostic and prognostic significance of serum and tissue trace elements in breast malignancy. Indian J Med Sci 1994; 48(10):227- 32.
  • Chan A, Wong F, Arumanayagam M. Serum ultrafıltrable copper, total copper and ceruloplasmin concentrations in gynaecological carcinomas. Clin Biochem 1993;30 (Pt 6): 545-9.
  • Songchitsomboon S, Komindr S, Komindr A, Kulapongse S. Serum copper and zinc levels in Thai patients with various diseases. J Med Assoc Thai 1999;82(7): 701- 6.
  • Fenton MR, Burke JP. Subcellular zinc distribution in livers and tumors plasmocytoma-bearing mice. Nutr. Res. 1985;5(12): 1383-91.
  • Senra VA, Lopez SJJ, Quintela SD. Serum ceruloplasmin as a diagnostic marker of cancer. Cancer Lett 1997;121(2): 139-45.
  • Hoth DR, Petrucci PE. Naturel history and staging of colon cancer. Semin Oncol. 1976;3(4):331-6.
  • Agroyannis B, Dalamangas A, Dardouphas K, et al. Serum transferrin and ceruloplasmin in patients with cancer of the gastrointestinal and other systems. Anticancer Res 1994;14(5B): 2201-3.

Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri

Year 2014, , 32 - 36, 01.04.2014

Tanboğa B Mehmet Ali Akkuş

https://doi.org/10.18521/ktd.99634

Abstract

Amaç: Bu çalışmada, kolorektal kanserli hasta grubunda; bakır, çinko, bakır/çinko ve seruloplazmin oranlarının prognoza olan etkisi araştırılmaktadır. Yöntem: Bu çalışma prospektif, kesitsel bir vaka kontrol çalışması olarak planlandı. Temmuz 2006-Nisan 2007 tarihleri arasında S.B. Ankara Eğitim ve Araştırma Hastanesi Genel Cerrahi polikliniklerinde kolorektal kanser tanısı almış 25-75 yaş arası (ortalama 57), 22’si erkek ve 13’ü kadın olmak üzere toplam 35 hasta çalışmaya dahil edildi. Kontrol grubu olarak hastane personelinden 25-64 yaş arası (ortalama 49) herhangi bir klinik şikayeti ve laboratuar bulgusu olmayan, sağlıklı 20 (11 erkek, 9 kadın) kişi seçildi. Kan örnekleri hasta grubunda preoperatif dönemde, kontrol grubunda herhangi bir zamanda alınarak serum seruloplazmin, bakır ve çinko seviyelerine bakıldı. Bulgular: Tümör lokalizasyonları erkek hastaların %29’unda rektumda, %34’üde kolonun diğer bölgelerinde, kadın hastaların ise %13’ünde rektumda, %14’ünde kolonun değişik bölgelerindeydi. Dukes sınıflamasına göre yapılan, tümör evresi ile serum bakır (p=0.001) ve çinko (p=0.001) seviyeleri arasında anlamlı bir ilişki saptandı. İleri tümör evresi ile serum seruloplazmin ve serum bakır/çinko oranı arasında anlamlı bir ilişki olduğu saptandı (p=0.001). Hasta grubunda serum çinko düzeyinde belirgin azalma olduğu tespit edildi (p=0.001). Sonuçlar: Bizim çalışmamızın litaratüre olan katkısı ise tümor markırı olarak kullanılan CEA15.5, Ca 50, ferritin gibi birçok parametreye ilaveten bakır, çinko gibi elementlerden yalnız bir parametre bağlı değil; çinko, bakır, seruloplazmin ve Cu/Zn oranının birlikte değerlendirmeye alınması özellikle kolerektal kanserlerde tarama, erken tanı, verilen tedavinin etkinliğini saptama ve prognoz belirlemede daha değerli bilgiler verdiği kanatindeyiz

Keywords

Kolorektal Kanser Bakır Çinko Seruloplazmin

References

  • Thomson DM, Krupey J, Freedman SO, Gold P. The radioimmunassay of circulating carcinoembriyojenic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969;64(1):161-7. 2. Yaşar M, Kayıkçı A. Kolonoskopi Sonuçlarımızın Retrospektif Analizi [Retrospective Evaluation of Colonoscopy Results]. Konuralp Tıp Dergisi 2010;2(3):6-9.
  • Burtis C, Ashwood AR. Tietz Textbook of Clinical Chemistry, 2nd ed,. Philadelphia: WB Saunders Company, 1994;897-920.
  • Waldmann TA, Hebernan RH. Tumor markers in Diagnosis and Monitoring Therapy. In: Holland JF, Feri E, eds. Cancer Medicine, Philadelphia: Lea Febiger, 1982:1086-9.
  • Piccinini L, Borella P, Bargellini A, Zoboli A: A case-control study on selenium zinc and copper in plasma and hair of subjects affected by breast and lung cancer. Biol Trace Elem Res 1996:51(l): 23-30.
  • Jayadeep A, Raveendran PK, Kannan S, et al. Serum level of copper, zinc, iron and ceruplasmin in oral leukoplakia and squamous celi carcinoma. Exp Clin Cancer Res 1997;16(3): 295-300.
  • Janssen AM, Bosman CB, Kruidenier L, et al. Superoxide dismutases in the human colorectal cancer sequence. Res Clin Oncol 1999;125(6): 327-35
  • Magalova T, Bela V, Brtkova A, Beno L, Kudlackova M, Volkovova K. Copper, zinc and superoxide dismutase in precancerous, benign diseases and gastric, colorectal and breast cancer. Neoplasma 1999; 46(2):100-4.
  • Zowczak M, Iskra M, Torlinski L, Cofta S. Analysis of serum copper and zinc concentrations in cancer patients. Biol Trace Elem Res 2001;82(l-3): l-8.
  • Bessmel'tsev SS, Rybakova LP, Gritskevich NL, Golota GZ, Blinov MN, Abdulkadyrov KM. Diagnostic and prognostic significance of blood-serum ceruloplasmin, acetylcholinesterase and total proteolytic activity in patients with multiple myeloma. Vopr Onkol 1999;45(4): 398-404.
  • Burtis CA, Ashwood ER. Tietz textbook of clinical chemistry, 3rd ed. Philadelphia: WB Saunders, 1999; 490:1016-41.
  • Sharma K, Piccinini L, Mittal DK, Kesarwani RC, Kamboj VP, Chovvdhery. Diagnostic and prognostic significance of serum and tissue trace elements in breast malignancy. Indian J Med Sci 1994; 48(10):227- 32.
  • Chan A, Wong F, Arumanayagam M. Serum ultrafıltrable copper, total copper and ceruloplasmin concentrations in gynaecological carcinomas. Clin Biochem 1993;30 (Pt 6): 545-9.
  • Songchitsomboon S, Komindr S, Komindr A, Kulapongse S. Serum copper and zinc levels in Thai patients with various diseases. J Med Assoc Thai 1999;82(7): 701- 6.
  • Fenton MR, Burke JP. Subcellular zinc distribution in livers and tumors plasmocytoma-bearing mice. Nutr. Res. 1985;5(12): 1383-91.
  • Senra VA, Lopez SJJ, Quintela SD. Serum ceruloplasmin as a diagnostic marker of cancer. Cancer Lett 1997;121(2): 139-45.
  • Hoth DR, Petrucci PE. Naturel history and staging of colon cancer. Semin Oncol. 1976;3(4):331-6.
  • Agroyannis B, Dalamangas A, Dardouphas K, et al. Serum transferrin and ceruloplasmin in patients with cancer of the gastrointestinal and other systems. Anticancer Res 1994;14(5B): 2201-3.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Tanboğa B This is me

Mehmet Ali Akkuş This is me

Publication Date April 1, 2014
Published in Issue Year 2014

Cite

APA B, T., & Akkuş, M. A. (2014). Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri. Konuralp Medical Journal, 6(1), 32-36. https://doi.org/10.18521/ktd.99634
AMA B T, Akkuş MA. Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri. Konuralp Medical Journal. April 2014;6(1):32-36. doi:10.18521/ktd.99634
Chicago B, Tanboğa, and Mehmet Ali Akkuş. “Kolorektal Kanserlerde Serum Bakır, Çinko Ve Seruloplazmin Oranlarının Prognostik Değerleri”. Konuralp Medical Journal 6, no. 1 (April 2014): 32-36. https://doi.org/10.18521/ktd.99634.
EndNote B T, Akkuş MA (April 1, 2014) Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri. Konuralp Medical Journal 6 1 32–36.
IEEE T. B and M. A. Akkuş, “Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri”, Konuralp Medical Journal, vol. 6, no. 1, pp. 32–36, 2014, doi: 10.18521/ktd.99634.
ISNAD B, Tanboğa - Akkuş, Mehmet Ali. “Kolorektal Kanserlerde Serum Bakır, Çinko Ve Seruloplazmin Oranlarının Prognostik Değerleri”. Konuralp Medical Journal 6/1 (April 2014), 32-36. https://doi.org/10.18521/ktd.99634.
JAMA B T, Akkuş MA. Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri. Konuralp Medical Journal. 2014;6:32–36.
MLA B, Tanboğa and Mehmet Ali Akkuş. “Kolorektal Kanserlerde Serum Bakır, Çinko Ve Seruloplazmin Oranlarının Prognostik Değerleri”. Konuralp Medical Journal, vol. 6, no. 1, 2014, pp. 32-36, doi:10.18521/ktd.99634.
Vancouver B T, Akkuş MA. Kolorektal Kanserlerde Serum Bakır, Çinko ve Seruloplazmin Oranlarının Prognostik Değerleri. Konuralp Medical Journal. 2014;6(1):32-6.