Endemik Bölgede Brucella Spondilodiskitis: 18 Hastanın Retrospektif Olarak Gözden Geçirilmesi

H Sözen

doi:10.18521/ktd.25432

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Year 2015, , 134 - 140, 20.11.2015

H Sözen

https://doi.org/10.18521/ktd.25432

Abstract

Aim: Osteoarticuler involvement is one of the most common complications of brucellosis and incidence is 10-85%. The major clinical manifestation of brucellar osteoarticuler involvement is spondylodiscitis. Our aim was to evaluate the brucellar spondylodiscitis. Method: Spondylodiscitis cases among patients diagnosed with brucellosis at Isparta Government Hospital between January 2005 and August 2011 were included in the study. Clinical and laboratory findings were analyzed retrospectively Results: The total number of brucellar spondylodiscitis was 18 out of 126 patients (14%). Lumbar and lumbosacral involvement was the most common location of brucellar lesions. All patients had lumbar pain and abnormal MRI findings. The average length of antibiotic therapy was 17.1 weeks Conclusion: Spondylodiscitis is an important complication of brucellosis. Brucellar spondylodiscitis, the clinical and laboratory findings Spondylodiscitis, the 6-week treatment period with a recurrence is a major problem. It is usually seen more frequently in elderly patients. Therefore, the middle aged with low back pain in patients with brucellosis necessarily MRI imaging should be performed. The duration of treatment according to the patient's clinical and laboratory findings should be regulated as at least 12 weeks

Keywords

Brucellar Spondylodiscitis, Complication, Therapy

References

Aydin G, Tosun A, Keles I, Ayaslioglu E, Tosun O, Orkun S. Brucellar spondylodiscitis: a case report. Int J Clin Pract 2006; 60(11):1502-5.
Lee HJ, Hur JW, Lee JW, Lee SR. Brucellar spondylitis. J Korean Neurosurg Soc 2008; 44(4):277-9.
Madkour MM. Brucellosis. In: Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Fauci AS, Editors. Harrison’s principles of internal medicine, 14th ed, New York: McGraw-Hill Professional, 2001;969-71.
Young EJ. Brucella species. In: Principles and Practice of Infectious Diseases Volume 2. 6th edition. Edited by: Mandell GL, Bennett JE, Dolin R. Philadelphia: Churchill Livingstone; 2005: 2669-74.
Solera J, Lozano E, Martinez-Alfaro E, Espinosa A, Castillejos ML, Abad L. Brucellar spondylitis: review of 35 cases and literatüre survey. Clin Infect Dis 1999; 29(6):1440-9.
Bodur H, Erbay A, Colpan A, Akinci E. Brucellar spondylitis. Rheumatol Int. 2004;24(4):221-6. Epub 2003 Jul 16.
Aygen B, Doganay M, Sumerkan B, Yildiz O, Kayabas U. Clinical manifestations, complications and treatment of brucellosis:a retrospective evaluation of 480 patients. Med Mal Infect 2002; (9):485-93.
Tasova Y, Saltoglu N, Sahin G, Aksu HSZ: Osteoarthicular involvement of brucellosis in Turkey. Clin Rheumatol 1999; 18(3):214-9.
Hashemi SH, Keramat F, Ranjbar M, Mamani M, Farzam A, Jamal-Omidi S. Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran. Int J Infect Dis. 2007;11(6):496-500. Epub 2007 Mar 6.
Geyik MF, Gür A, Nas K, Cevik R, Saraç J, Dikici B, Ayaz C. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly. 2002 Feb 23;132(7-8):98-105.
Bozgeyik Z, Ozdemir H, Demirdag, Ozden M, Sonmezgoz F, Ozgocmen S. Clinical and MRI findings of brucellar spondylodiscitis. European Journal of Radiology 2008;67(1): 153–8.
Doganay M, Aygen B. Human brucellosis: an overview. Int J Infect Dis 2003; 7(3):173-82.
Sathyanarayanan V, Razak A, Saravu K, Ananthakrishna SB, Mukhyprana Prabhu M, Vandana KE. Clinical profile of brucellosis from a tertiary care center in southern India. Asian Pac J Trop Med. 2011;4(5):397- 400. doi: 10.1016/S1995-7645(11)60111-9. Epub 2011 Jun 22.
Kaptan F, Gulduren HM, Sarsilmaz A, et al. Brucellar spondylodiscitis: comparison of patients with and without abscesses. Rheumatol Int. 2012 Jul 29. [Epub ahead of print].
Luzzatti R, Giacomazzi D, Danzi MC et al. Diagnosis, management and outcome of clinically-suspected spinal infection. J Infect 2009; 58(4):259-65.
Colmenero JD, Ruiz-Mesa JD, Plata A et al Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis. Clin Infect Dis 2008;46(3):426-33.
Finn TB. Brucellosis. In: Armstrong D, Cohen J (eds) Infectious diseases. Geographic and travel medicine. London: Harcourt Publishers, 1999:15–7.
Gonzales-Gay MA, Garcia-Porrua C, Ibanez D et al. Osteoarticular complications of brucellosis in an Atlantic area of Spain. J Rheumatol 1999; 26(1):141–5.
Namiduru M, Karaoglan I, Gursoy S, Bayazıt N, Sirikci A. Brucellosis of the spine: evaluation of the clinical, laboratory, and radiological findings of 14 patients. Rheumatol Int 2004;24(3):125-9.
Ioannou S, Karadima D, Pneumaticos S, et al. Efficacy of prolonged antimicrobial chemotherapy for brucellar spondylodiscitis. Clin Microbiol Infect. 2011;17(5):756-62.
Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. International Journal of Infectious Diseases 2010;14(6):e469-78..
Bosilkovski M, Krteva I, Caparoska S et al. Osteoarticular involvement in brucellosis: a study of 196 cases in the Republic of Macedonia. Croat Med J 2004;45(6):727-33.
Turunc T, Demiroglu YZ, Uncu H et al. A comparative analysis of tuberculous, brucellar and pyogenic spontaneous spondylodiscitis patients. J Infect 2007;55(2):158-63. Epub 2007 Jun 7.
Alp E, Koc RK, Durak AC, et al. Doxycycline plus streptomycin versus ciprofloxacin plus rifampicin in spinal brucellosis [ISRCTN31053647] BMC Infectious Diseases 2006;6: 72.
Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical Manifestations of Human Brucellosis: A Systematic Review and Meta-Analysis. PLOS Neglected Tropical Diseases 2012;6(12): 1929.
Mantur BG, Mangalgi SS. Evaluation of conventional castaneda and lysis centrifugation blood culture techniques for diagnosis of human brucellosis. J Clin Microbiol 2004; 42(9):4327-8.
Eini P, Keramat F, Hasanzadehhoseinabadi M. Epidemiologic, clinical and laboratory findings of patients with brucellosis in hamadan, west of İran. J Res Health Sci 2012;12(2): 105-8.
Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents. 2010 Nov;36 Suppl 1:S18- 20. doi: 10.1016/j.ijantimicag.2010.06.015. Epub 2010 Aug 6.
Pourbagher A, Pourbagher MA, Savas L et al. Epidemiologic, clinical, and imaging findings in brucellosis patients with osteoarticular involvement. AJR Am J Roentgenol 2006; 187(4):873-80.
Ozaksoy D, Yucesoy K, Yucesoy M et al. Brucellar spondylitis: MRI findings. Eur Spine J 2001;10(6): 529–33.
Ulu-Kilic A, Sayar MS, Tutuncu E, Sezen F, Sencan I. Complicated brucellar spondylodiscitis: experience from an endemic area. Rheumatol Int 2013;33(11):2909-12.