Gestasyonel Diyabetes Mellitus Patogenezinde AB0 Kan Grubu Fenotipleri ve Rhesus Faktörü

Year 2024, , 278 - 282, 29.10.2024

Adem Keskin , Recai Aci , Mukadder Erdem , Eda Türe , Mahcube Cubukcu

https://doi.org/10.18521/ktd.1525270

Abstract

Amaç: Bazı AB0 kan grubu fenotipleri hem tip II diabetes mellitus (DM) hem de tip I DM'nin patogenezinde risk faktörü olarak kabul edilebilir. Bu çalışmanın amacı, bazı AB0 kan grubu fenotiplerinin ve Rhesus (Rh) faktörünün, gestasyonel diabetes mellitus (GDM) tanısı almış gebe kadınlarda hastalığın ortaya çıkması için risk faktörü olup olmadığını araştırmaktır.
Metod: Bu çalışma bir vaka-kontrol çalışması olup veriler retrospektif olarak analiz edildi. Bir eğitim ve araştırma hastanesine bir yıl süreyle başvuran ve 75 gram oral glukoz tolerans testi (OGTT) yaptıran gebe kadınlar çalışmaya dahil edildi. OGTT sonuçlarına göre GDM tanısı almış gebe kadınlar (vaka grubu) ve sağlıklı gebe kadınlar (kontrol grubu) iki gruba ayrıldı.
Bulgular: Bir yıllık veri taramasında GDM prevalansı %15,94 olarak bulundu. GDM'li gebelerin yaş ortalaması sağlıklı gebelere göre daha yüksek bulundu (p<0,001). GDM'li gebeler ile sağlıklı gebelerde AB0 kan grubunun yüzdelik frekans dağılımları arasında anlamlı bir fark yoktu (p>0,05). Her iki grubun Rh faktörü pozitifliği farklı değildi (p>0,05).
Sonuç: Sonuç olarak GDM patogenezi ve AB0 kan grubu fenotipleri ile Rh faktörü arasında bir ilişki bulunamadı.

Keywords

AB0 kan grubu, Gestasyonel diyabet, Rh faktörü

AB0 Blood Group Phenotypes and Rhesus Factor in The Pathogenesis of Gestational Diabetes Mellitus

Abstract

Objective: Some AB0 blood group phenotypes may be considered as risk factors in the pathogenesis of both type II diabetes mellitus (DM) and type I DM. The aim of this research was to investigate whether there is a relation between AB0 blood group phenotypes and Rhesus (Rh) factor and the occurrence of the disease in pregnant female diagnosed with gestational diabetes mellitus (GDM).
Method: This research was case-control research, and the data were analyzed retrospectively. Pregnant women who were admitted to a research and teaching hospital for one year and underwent a 75 gram oral glucose tolerance test (OGTT) were included in the research. Pregnant females diagnosed with GDM according to OGTT results were separated into two groups as case group and healthy pregnant females as control group.
Result: The prevalence of GDM was found to be 15.94% in a one-year data review. The mean age of pregnant females with GDM was higher than healthy pregnant females (p<0.001). There was no important difference between the percentage frequency distribution of AB0 blood group in pregnant females with GDM and healthy pregnant females (p>0.05). Rh factor positivity of both groups was not different (p>0.05).
Conclusion: In conclusion, no association was found between the pathogenesis of GDM and AB0 blood group phenotypes and Rh factor.

Keywords

AB0 blood group, Gestational diabetes, Rh factor

Thanks

We would like to express our gratitude to the blood center and laboratory staff of the hospital where this study was conducted and to the hospital administration for providing us with all kinds of facilities during our study. We would also like to express our gratitude to Assoc. Prof. Dr. Canan Soyer Çalışkan, Chief of Gynecology and Obstetrics Clinic, who approved the conduct of our study.

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