Yaygın Anksiyete Bozukluğu Olan Çocuk ve Ergenlerde Sistemik İnflamasyon İlişkili Hemogram Biyobelirteçlerinin İncelenmesi

Year 2020, , 534 - 538, 20.10.2020

Nihal Yurteri , İbrahim Ethem Şahin

https://doi.org/10.18521/ktd.789566

Abstract

Amaç: Bu çalışmada yaygın anksiyete bozukluğu olan (YAB) çocuk ve ergenlerde tam kan sayımından bakılan sistemik inflamasyon biyo-belirteçlerinin düzeylerinin incelenmesi amaçlanmıştır.

Yöntem: Retrospektif olarak 48 YAB tanılı çocuk ergen ile yaş-cinsiyet açısından eşleştirilmiş 46 sağlıklı kontrol çocuk ve ergenin tam kan sayımı sonuçları; hemoglobin (Hb), eritrosit dağılım genişliği (RDW), trombosit sayısı (PLT), ortalama trombosit hacmi (MPV), trombosit dağılım genişliği (PDW), plateletkrit (PCT), beyaz kan hücre sayımı (WBC), nötrofil, lenfosit ve monosit sayıları ve nötrofil / lenfosit oranı (NLR), monosit / lenfosit oranı (MLR), trombosit / lenfosit oranları (PLR) açısından karşılaştırıldı. İstatistiksel değerlendirmede ki-kare testi, bağımsız örneklemler t-testi ve Mann-Whitney U testi kullanıldı.

Bulgular: YAB olan çocuk ve ergenlerde, MPV düzeyleri anlamlı olarak yüksek (p = 0,020) ve PLT ve PDW düzeyleri anlamlı olarak düşük (sırasıyla p = 0,018 ve p = 0,011) bulundu. Hb, RDW, PCT, WBC, nötrofil, lenfosit ve monosit sayıları, NLR, MLR, PLR açısından olgu ve kontrol grupları arasında istatistiksel olarak anlamlı bir farklılık saptanmadı.

Sonuç: MPV ve PDW gibi inflamasyonla ilişkili olduğu öne sürülen trombosit parametreleri, çocuk ve ergenlerde YAB'nin olası inflamatuar arka planıyla ilişkili olabilir ve bu konuda kapsamlı ileriye dönük çalışmalara ihtiyaç vardır.

Bu makale için 17-03-2021 tarihinde bir düzeltme yayınlandı. https://dergipark.org.tr/tr/pub/ktd/issue/60658/897382 

Keywords

Anksiyete bozukluğu, İnflamasyon, Hemogram, Tam kan sayımı, Çocuk ve ergenler

Supporting Institution

yok

Project Number

yok

Examination of Systemic Inflammation Related Hemogram Biomarkers in Children and Adolescents with Generalized Anxiety Disorder

Abstract

Objective: In this study, we aimed to examine the complete blood count parameters and blood-based systemic inflammatory markers in children with generalized anxiety disorder (GAD).

Method: Retrospectively, complete blood count of 48 GAD diagnosed children and adolescents and age-gender matched 46 healthy controls were compared in terms of hemoglobin (Hb), erythrocyte distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), white blood cell count (WBC), neutrophil, lymphocyte and monocyte counts and neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratios (PLR). Chi-square test, independent samples t-test and Mann-Whitney U test were used for statistical evaluation.

Results: MPV levels were found to be significantly higher (p=0.020), while PLT and PDW levels were found to be significantly lower (p=0.018 and p=0.011, respectively) in children and adolescents with GAD. There was no statistically significant difference in terms of hemoglobin (Hb), erythrocyte distribution width (RDW), plateletcrit (PCT), white blood cell count (WBC), neutrophil, lymphocyte and monocyte counts and neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratios (PLR) between case and control groups.

Conclusion: Platelet parameters that have been postulated to be associated with inflammation, such as MPV and PDW may be related to possible inflammatory background of GAD in children and adolescents and comprehensive prospective studies are required on this subject.

An Erratum to this article was published on 17 March 2021. https://dergipark.org.tr/en/pub/ktd/issue/60658/897382 

Keywords

anxiety disorder, inflammation, hemogram, complete blood count, children and adolescents

Project Number

yok

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