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Gebelik Trimesterine Göre Ön Segment Parametrelerinin ve Retina Sinir Lifi Tabaka Kalınlığının Değerlendirilmesi

Year 2018, Volume: 10 Issue: 2, 213 - 217, 15.08.2018
https://doi.org/10.18521/ktd.359032

Abstract

Amaç: Gebeliğin ön segment
parametreleri ve retina sinir lifi kalınlığı (RNFL) üzerindeki etkilerini
incelemek.

Gereç
ve Yöntem:
Bu prospektif çalışma, 122’si
tekil gebe ve 49’u gebe olmayan kadınlar arasında yürütüldü. Göz içi basıncı
(GİB) Goldman Aplanasyon Tonometresi ile ölçüldü. Santral kornea kalınlığı
(SKK), aksiyel uzunluk (AxL) ve ön kamara derinliği ölçümleri (ÖKD) Echoscan US
500 ile yapıldı. RNFL kalınlığının ayrıntılı olarak
araştırılması için optik koherens tomografi kullanıldı. Normal dağılım grupları
arasında bir karşılaştırma yapmak için One Way ANOVA testi kullanıldı.

Bulgular: Yaşa bakımından
istatistiksel olarak anlamlı fark yoktu. GİB, birinci trimesterde 16.0 mmHg, 2.
trimesterde 14.6 mmHg, 3. trimesterde 13.6 mmHg ve gebe olmayanlarda 15.56 mmHg
idi. İstatistiksel olarak, 2. ve 3. trimesterlerin bulguları 1. trimesterden anlamlı olarak farklıydı (p = 0.033, p = 0.001, sırasıyla).
Gebe olmayan kadınlarda 542 μm iken, trimestere gore SKK ortalaması sırasıyla
554 μm, 564 μm ve 552 μm idi. 2. ve 3. trimesterdeki gebeliklerin ve gebe
olmayan kadınların SKK ortalamaları arasındaki fark
istatistiksel olarak anlamlıydı (p = 0.022, p = 0.041, sırasıyla). Dört
RNFL'nin ortalama kalınlığının karşılaştırılması, gebe ve gebe olmayan arasında
fark göstermedi.







Sonuç: Gebelik esnasında,
GİB’de azalma ile SKK’da bir artış bulundu. ÖKD, AxL
ve RNFL kalınlık ölçümlerinin hamilelik ile birlikte değişmediği de tespit
edildi.

References

  • 1.Demir M, Oba E, Can E, et al. Foveal and parafoveal retinal thickness in healthy pregnant women in their last trimester. Clin Ophthalmol 2011;5:1397-1400. 2.Grant AD, Chung SM, The eye in pregnancy: ophthalmologic and neuro-ophthalmologic changes. Clin Obstet Gynecol 2013;56(2):397-412. 3.Sertan G, Ahmet B, Yasar S, et al. Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography. Arq. Bras. Oftalmol 2014;77(3):148-51. 4.Omoti AE, Waziri-Erameh JM, Okeigbemen VW. A review of the changes in the ophthalmic and visual system in pregnancy. Afr J Reprod Health 2008;12(3):185-96. 5.Fuchsjager-Mayrl G, Nepp J, Schneeberger C, et al. Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. Invest Ophthalmol Vis Sci 2002;43(9):2841-4. 6.Esmaeli B, Harvey JT, Hewlett B. Immunohistochemical evidence for estrogen receptors in meibomian glands. Ophthalmology 2000;107(1):180-4. 7.Weinreb RN, Lu A, Key T. Maternal ocular adaptations during pregnancy. Obstet Gynecol Surv 1987;42(8):471-83. 8.Weinreb RN, Lu A, Beeson C. Maternal corneal thickness during pregnancy. Am J Ophthalmol 1988;105(3):258-60. 9.Green K, Phillips CI, Cheeks L, et al. Aqueous humor flow rate and intraocular pressure during and after pregnancy. Ophthal Res 1988;20(6): 353-7. 10.Davis E. Dana reza pregnancy and eye. In: Albert D, Jakobiec FA, ed. Principles and practice of ophthalmology. Philadelphia, WB Saunders 2000;4767-8474. 11.Efe YK, Ugurbas SC, Alpay A, et al. The course of corneal and intraocular pressure changes during pregnancy. Can J Ophthalmol 2012;47(2):150-4. 12.Kass MA, Sears ML. Hormonal regulation of intraocular pressure. Surv Ophthalmol 1977;22(3):153-76. 13.Phillips CI, Gore SM. Ocular hypotensive effect of late pregnancy with and without high blood pressure. Br J Ophthalmol 1985;69(2):117-9. 14.Afekhide E.O., Joseph M. W., Valentina W. O. A Review of the Changes in the Ophthalmic and Visual System in Pregnancy. Afr J Reprod Health 2008; 12(3):185-96. 15. Atas M, Duru N, Ulusoy DM, et al. Evaluation of anterior segment parameters during and after pregnancy. Cont Lens Anterior Eye 2014;37(6):447-50. 16.Sen E, Onaran Y, Nalcacioglu-Yuksekkaya P, et al. Corneal biomechanical parameters during pregnancy. Eur J Ophthalmol 2014;24(3):314-9. 17.Gupta PD, Johar K, Nagpal K, Vasavada AR. Sex hormone receptors in the human eye. Surv Ophthalmol 2005;50(3):274-84. 18.Suzuki T, Kinoshita Y, Tachibana M, et al. Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 2001;22(1):28-33. 19. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 2000;78(2):146-53. 20.el-Hage SG, Beaulne C. Changes in central and peripheral corneal thickness with menstrual cycle. Am J Optom Arch Am Acad Optom 1973;50(11):863-71. 21.Kiely PM, Carney LG, Smith G. Menstrual cycle variations of corneal topography and thickness. Am J Optom Physiol Opt 1983;60(10):822-9. 22. Giuffrè G, Di Rosa L, Fiorino F, Bubella DM, Lodato G. Variations in central corneal thickness during the menstrual cycle in women. Cornea 2007;26(2):144-6.

Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester

Year 2018, Volume: 10 Issue: 2, 213 - 217, 15.08.2018
https://doi.org/10.18521/ktd.359032

Abstract

Objective: To analyze the effects of
pregnancy on anterior segment parameters and retinal nerve fiber layer (RNFL) thickness
.



Methods: The
study designed prospectively conducted among 122 singleton pregnant women and
49 non-pregnant women. Intraocular
pressure (IOP) was measured via the
Goldman applanation tonometry. Central corneal
thickness (CCT), axial lenght (AxL) and anterior chamber depth (ACD)
measurement were performed with Echoscan
US 500. For investigating the thickness of
RNFL in detail, the optical coherence tomography
was used.
One Way ANOVA test
was used to make a comparison between normal distribution groups.



Results: There was no
statistically significant difference regarding age. The IOP were 16.0 mmHg in
the 1st trimester, 14.6 mmHg in the 2nd trimester, 13.6
mmHg in the 3rd trimester and 15.56 mmHg in the non-pregnant.
Statistically, the findings of the 2nd and the 3rd
trimester were significantly different from that of the 1st
trimester (p = 0.033, p = 0.001, respectively). CCT averages
were 554 μm, 564 μm and 552 μm, respectively, according to the trimester, while
it was 542 μm in non-pregnant women. The difference between CCT averages
between pregnancies in the 2nd and 3rd trimesters and
non-pregnant women was statistically significant (p = 0.022, p = 0.041,
respectively). The comparison of average thickness of four RNFL showed no
difference between the pregnant and non-pregnant.



Conclusion:
During gestation, there was
an increase in CCT with a decrease in IOP. We also determined that the ACD,
AxL, and RNFL thickness measurements do not change with pregnancy.

References

  • 1.Demir M, Oba E, Can E, et al. Foveal and parafoveal retinal thickness in healthy pregnant women in their last trimester. Clin Ophthalmol 2011;5:1397-1400. 2.Grant AD, Chung SM, The eye in pregnancy: ophthalmologic and neuro-ophthalmologic changes. Clin Obstet Gynecol 2013;56(2):397-412. 3.Sertan G, Ahmet B, Yasar S, et al. Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography. Arq. Bras. Oftalmol 2014;77(3):148-51. 4.Omoti AE, Waziri-Erameh JM, Okeigbemen VW. A review of the changes in the ophthalmic and visual system in pregnancy. Afr J Reprod Health 2008;12(3):185-96. 5.Fuchsjager-Mayrl G, Nepp J, Schneeberger C, et al. Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. Invest Ophthalmol Vis Sci 2002;43(9):2841-4. 6.Esmaeli B, Harvey JT, Hewlett B. Immunohistochemical evidence for estrogen receptors in meibomian glands. Ophthalmology 2000;107(1):180-4. 7.Weinreb RN, Lu A, Key T. Maternal ocular adaptations during pregnancy. Obstet Gynecol Surv 1987;42(8):471-83. 8.Weinreb RN, Lu A, Beeson C. Maternal corneal thickness during pregnancy. Am J Ophthalmol 1988;105(3):258-60. 9.Green K, Phillips CI, Cheeks L, et al. Aqueous humor flow rate and intraocular pressure during and after pregnancy. Ophthal Res 1988;20(6): 353-7. 10.Davis E. Dana reza pregnancy and eye. In: Albert D, Jakobiec FA, ed. Principles and practice of ophthalmology. Philadelphia, WB Saunders 2000;4767-8474. 11.Efe YK, Ugurbas SC, Alpay A, et al. The course of corneal and intraocular pressure changes during pregnancy. Can J Ophthalmol 2012;47(2):150-4. 12.Kass MA, Sears ML. Hormonal regulation of intraocular pressure. Surv Ophthalmol 1977;22(3):153-76. 13.Phillips CI, Gore SM. Ocular hypotensive effect of late pregnancy with and without high blood pressure. Br J Ophthalmol 1985;69(2):117-9. 14.Afekhide E.O., Joseph M. W., Valentina W. O. A Review of the Changes in the Ophthalmic and Visual System in Pregnancy. Afr J Reprod Health 2008; 12(3):185-96. 15. Atas M, Duru N, Ulusoy DM, et al. Evaluation of anterior segment parameters during and after pregnancy. Cont Lens Anterior Eye 2014;37(6):447-50. 16.Sen E, Onaran Y, Nalcacioglu-Yuksekkaya P, et al. Corneal biomechanical parameters during pregnancy. Eur J Ophthalmol 2014;24(3):314-9. 17.Gupta PD, Johar K, Nagpal K, Vasavada AR. Sex hormone receptors in the human eye. Surv Ophthalmol 2005;50(3):274-84. 18.Suzuki T, Kinoshita Y, Tachibana M, et al. Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 2001;22(1):28-33. 19. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 2000;78(2):146-53. 20.el-Hage SG, Beaulne C. Changes in central and peripheral corneal thickness with menstrual cycle. Am J Optom Arch Am Acad Optom 1973;50(11):863-71. 21.Kiely PM, Carney LG, Smith G. Menstrual cycle variations of corneal topography and thickness. Am J Optom Physiol Opt 1983;60(10):822-9. 22. Giuffrè G, Di Rosa L, Fiorino F, Bubella DM, Lodato G. Variations in central corneal thickness during the menstrual cycle in women. Cornea 2007;26(2):144-6.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Kuddusi Teberik

Alper Başbuğ

Hakan Sağlam This is me

Musa Karaarslan This is me

Murat Kaya This is me

Publication Date August 15, 2018
Acceptance Date April 18, 2018
Published in Issue Year 2018 Volume: 10 Issue: 2

Cite

APA Teberik, K., Başbuğ, A., Sağlam, H., Karaarslan, M., et al. (2018). Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester. Konuralp Medical Journal, 10(2), 213-217. https://doi.org/10.18521/ktd.359032
AMA Teberik K, Başbuğ A, Sağlam H, Karaarslan M, Kaya M. Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester. Konuralp Medical Journal. August 2018;10(2):213-217. doi:10.18521/ktd.359032
Chicago Teberik, Kuddusi, Alper Başbuğ, Hakan Sağlam, Musa Karaarslan, and Murat Kaya. “Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester”. Konuralp Medical Journal 10, no. 2 (August 2018): 213-17. https://doi.org/10.18521/ktd.359032.
EndNote Teberik K, Başbuğ A, Sağlam H, Karaarslan M, Kaya M (August 1, 2018) Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester. Konuralp Medical Journal 10 2 213–217.
IEEE K. Teberik, A. Başbuğ, H. Sağlam, M. Karaarslan, and M. Kaya, “Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester”, Konuralp Medical Journal, vol. 10, no. 2, pp. 213–217, 2018, doi: 10.18521/ktd.359032.
ISNAD Teberik, Kuddusi et al. “Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester”. Konuralp Medical Journal 10/2 (August 2018), 213-217. https://doi.org/10.18521/ktd.359032.
JAMA Teberik K, Başbuğ A, Sağlam H, Karaarslan M, Kaya M. Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester. Konuralp Medical Journal. 2018;10:213–217.
MLA Teberik, Kuddusi et al. “Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester”. Konuralp Medical Journal, vol. 10, no. 2, 2018, pp. 213-7, doi:10.18521/ktd.359032.
Vancouver Teberik K, Başbuğ A, Sağlam H, Karaarslan M, Kaya M. Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester. Konuralp Medical Journal. 2018;10(2):213-7.