Risk Factors For Diabetic Polyneuropathy

Year 2020, Volume: 12 Issue: 3, 486 - 491, 20.10.2020

Esra Aciman Demirel , Burcu Karpuz , Ulufer Çelebi , Mustafa Açıkgöz , Hüsyin Tuğrul Atasoy

https://doi.org/10.18521/ktd.744679

Abstract

Objective: Diabetes Mellitus is one of the most common metabolic diseases. The most frequent complication of DM is diabetic polyneuropathy.Diabetic polyneuropathy is related to high mortality, morbidity, hospitalization rate and serious level of economic burden. We aimed in this study to determine the risk factors that affect DPN pathology.

Method: Patients with abnormalities in the nerve conduction study constituted the polyneuropathy group, and patients without abnormalities formed the control group When the laboratuary values of the patients were analyzed, blood tests of 168 of 202 patients were reached. 117 of these patients had PNP and 51 did not have PNP.

Results:
In patients with PNP, glycolyzed hba1c ratio and fasting blood sugar were significantly higher than patients without PNP. (p <.001)
While HDL rate was lower in patients with PNP than those without PNP (p <0.01), TG / HDL ratio was higher (p <0.05). In patients with PNP, glycolyzed urea (p <0.001) and creatinine (p <0.01) were significantly higher than those without PNP. The serum level of 25 (OH) vitamin D was significantly lower in patients with PNP than in patients without PNP (p <0.05). Ferritin was significantly higher in patients with PNP than patients without (P <0 .01).

Conclusion: Knowing and preventing risk factors for diabetic polyneuropathy, we can take a new direction to our treatment approaches and take early measures. Fasting blood sugar and hba1c control, regulation of lipid profile, monitoring of vitamin d and ferritin levels are particularly necessary for protection of polyneuropathy.

Keywords

diabetic polyneuropathy, hba1c, ferritin

Diyabetik Polinöropati Risk Faktörleri

Abstract

Amaç: Diyabet Mellitus(DM) en yaygın metabolik hastalıklardan biridir. DM' nin en sık görülen komplikasyonu diyabetik polinöropatidir. Diyabetik polinöropati (DPN) yüksek mortalite, morbidite, hastaneye yatış oranı ve ciddi ekonomik yük ile ilişkilidir. Biz çalışmada DPN patolojisini etkileyen risk faktörlerini belirlemeyi amaçladık.

Yöntem: Sinir iletim çalışmasında anormalliği olan hastalar polinöropati grubunu, anormalliği olmayan hastalar kontrol grubunu oluşturdu. Hastaların laboratuvar değerleri incelendiğinde 202 hastanın 168'inin kan testlerine ulaşıldı. Bu hastaların 117'sinde DPNvarken, 51'inde DPN yoktu.

Bulgular: DPN olan hastalarda glikolize hemoglobin A1c (HbA1c)oranı, açlık kan şekeri DPN olmayan hastalara göre anlamlı olarak yüksek bulundu (p <0,001). DPN’si olan hastalarda HDL oranı DPN’si olamayan hastalara göre düşük saptanırken (p < 0,01), TG/HDL-K oranı daha yüksek saptandı (p < 0,05). DPN olan hastalarda glikolize üre (p < 0,001) ve kreatinin (p < 0,01), DPN olmayan hastalara göre anlamlı olarak yüksek saptandı. DPN olan hastalarda 25(OH) vitamin D düzeyi DPN olmayan hastalara göre anlamlı olarak düşüktü (p < 0,05). DPN olan hastalarda ferritin, olmayan hastalara göre anlamlı olarak daha yüksek saptandı (p <0 ,01).

Sonuç: Diyabetik polinöropati açısından risk faktörlerinin bilinmesi ve önlenmesi ile tedavi yaklaşımlarımıza yeni bir yön vererek erken önlemler alabiriz. Açlık kan şekeri, HbA1ckontrolü, lipid profilinin düzenlenmesi, 25(OH) vitamin D düzeyive ferritin düzeylerinin takibi özellikle korunma açısından önemlidir.

Keywords

Diyabetik polinöropati, HbA1C, Ferritin

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