Radikal Prostatektomi Uygulanan Hastalarda Deri Altı Yağ Kalınlığının Biyokimyasal Nüks ve Nükssüz Sağkalım Üzerine Etkisi

Year 2024, Volume: 16 Issue: 2, 161 - 167, 30.06.2024

Özgür Efiloğlu , Ayberk İplikçi , Nesrin Gündüz , Mahmut Bilal Dogan , Mehmet Çağlar Çakıcı , Asıf Yıldırım

https://doi.org/10.18521/ktd.1472283

Abstract

Amaç: Bu çalışmanın amacı radikal prostatektomi (RP) uygulanan hastalarda deri altı yağ kalınlığı (DAYK) ile biyokimyasal nüks (BKN) arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntem: Çalışmaya Nisan 2015 ile Ocak 2020 tarihleri arasında merkezimizde RP uygulanan toplam 52 metastatik olmayan prostat kanseri tanılı hasta dahil edildi. Tüm hastalara ameliyattan önceki altı ay içinde tüm batın bilgisayarlı tomografi (BT) taraması yapıldı. Yağ, kas ve doku ölçümleri iki radyolog tarafından yapıldı ve BKN’yi etkileyen faktörleri belirlemek için ikili lojistik regresyon analizi uygulandı. DAYK, nüksü etkileyen tek radyolojik faktör olarak tanımlandı. ROC eğrisi kullanılarak kesme değeri (25,6) belirlendi ve hastalar bu değere göre iki gruba ayrıldı.
Bulgular: Grup 1'de (DAYK < 25,6) ortanca nüks süresi 39 (3-65) ay, ortanca takip süresi ise 40,5 (17-65) ay idi. Grup 2'de (DAYK ≥ 25,6) ortanca nüks süresi 20,5 (3-58) ay, ortanca takip süresi ise 43 (12-69) ay idi. Bir yıllık ve üç yıllık nükssüz sağkalım oranları Grup 1'de sırasıyla %82,1 ve %78,4 iken Grup 2'de sırasıyla %62,5 ve %52,2 idi (p=0,047).
Sonuç: Prostat kanserinde nüksü tahmin edebilmek hastalığın yönetimi için çok önemlidir. DAYK ile BKN arasında anlamlı bir ilişki olduğunu ortaya koyan çalışmamız; hastalığın tanı, tedavi ve takibinde radyolojik değerlendirme ve ölçümlerden daha fazla yararlanılacağını düşündürmektedir.

Keywords

biyokimyasal nüks, prostat kanseri, deri altı yağ kalınlığı

Impact of Subcutaneous Fat Thickness on Biochemical Recurrence and Recurrence-Free Survival in Patients Undergoing Radical Prostatectomy

Abstract

Objective: Aim of this study is to evaluate the association between subcutaneous fat thickness (SCFT) and biochemical recurrence (BCR) in patients who have undergone radical prostatectomy (RP).
Material and Methods: Study included 52 patients who had non-metastatic prostate cancer (PCa), underwent RP at our center between April 2015 and January 2020. All patients had a full abdomen computed tomography (CT) scan within six months prior to surgery. Measurements of fat, muscle, and tissue were evaluated by two radiologists, and binary logistic regression analysis was performed to determine factors influencing BCR. SCFT was identified as the only radiological factor influencing recurrence. A cut-off value (25.6) was determined using an ROC curve, and patients were divided into two groups based on this value.
Results: In Group 1 (SCFT < 25.6), the median recurrence time was 39 (3-65) months, and the median follow-up time was 40.5 (17-65) months. In Group 2 (SCFT ≥ 25.6), the median recurrence time was 20.5 (3-58) months, and the median follow-up time was 43 (12-69) months. The one-year and three-year recurrence-free survival rates were 82.1% and 78.4% for Group 1, respectively, while they were 62.5% and 52.2% for Group 2, respectively (p=0.047).
Conclusions: The ability to predict recurrence in PCa is crucial for the management and treatment of the disease. Our study, which demonstrates a significant relationship between SCFT and BCR, suggests that radiological evaluation and measurements will be further utilized in the diagnosis, treatment, and follow-up of the disease.

Keywords

biochemical recurrence, prostate cancer, subcutaneous fat thickness

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