COVID 19: The Relationship Among Angiotensin-Converting Enzyme 2 (ACE 2), Renin-Angiotensin-Aldesterone System (RAS), and Chronic Diseases

Year 2021, Volume: 2 Issue: 2, 61 - 72, 30.08.2021

Meryem Topal , Sevim Beyza Öztürk Sarıkaya , Fevzi Topal

Abstract

SARS CoVID-2 (COVID-19), the seventh type of coronavirus that causes infections in humans, has become a major threat to human life worldwide. The virus, which emerged in Wuhan and spread from there to the whole world, has become a major threat, especially in elderly and chronic patients (hypertension, Diabetes Mellitus (DM), heart disease) today. It is very important to know why this virus is more effective in chronic patients, in the prevention or treatment of the disease. Therefore, the study describes the relationship of the COVID-19 virus with chronic diseases. Angiotensin-converting enzyme (ACE2) is particularly involved in vital organs such as the kidney, heart, liver, and lungs. The entry of the COVID-19 virus into the cell is through the ACE2 enzyme. In our study, the reasons why this virus affects chronic patients more than other people and its relationship with ACE2, Renin-Angiotensin-Aldosterone metabolism are tried to be elucidated.

Keywords

ACE 2, Chronic disease, Corona virus, SARS CoVID-2, COVID-19, Renin

COVID 19: Anjiyotensin Dönüştürücü Enzim 2 (ACE2), Renin-Anjiyotensin-Aldosteron Sistemi (RAAS) ve Kronik Hastalıklar Arasındaki İlişki

Abstract

İnsanlarda enfeksiyonlara neden olan yedinci tip koronavirüs olan SARS CoVID-2 (COVID-19), dünya çapında insan yaşamı için büyük bir tehdit haline gelmiştir. Wuhan’da ortaya çıkan ve oradan da tüm dünyaya yayılan virüs, bugün özellikle yaşlı ve kronik hastalarda (hipertansiyon, Diabetes Mellitus (DM), kalp hastalığı) büyük bir tehdit haline gelmiştir. Bu virüsün niçin kronik hastalarda daha etkili olduğunu bilmek hastalığın önlenmesi veya tedavisinde oldukça önemlidir. Bu nedenle çalışmada COVID-19 virüsünün kronik hastalıklar ile olan ilişkisi anlatılmaktadır. Angiotensin-converting enzyme (ACE2), özellikle böbrek, kalp, karaciğer, ve akciğerler gibi yaşam için önemli organlarda rol almaktadır. COVID-19 virüsünün hücre içerisine girişi ise ACE2 enzimiyledir. Çalışmamızda bu virüsün kronik hastaları diğer insanlardan daha fazla etkilenmesinin nedenleri ve ACE2, Renin-Anjiyotensin-Aldosteron metabolizması ile ilişkisi aydınlatılmaya çalışılmaktadır.

Keywords

ACE 2, Kronik hastalık, Corona virüs, SARS CoVID-2, COVID-19, Renin

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