HOMA-IR ve eGFR Değerleri Arasındaki Korelasyon

Year 2022, Volume: 3 Issue: 3, 17 - 24, 29.12.2022

Mehmet Özdin , Durhasan Mundan

Abstract

Amaç: Bu çalışmada amaç, bir eğitim ve araştırma hastanesinin farklı polikliniklerine farklı şikayetlerle başvuran bireylerin insülin direncinin homeostatik model değerlendirmesi (HOMA-IR) değerleri ile tahmini glomerüler filtrasyon hızı değerleri (eGFR) arasındaki korelasyonu belirlemektir.
Gereç ve Yöntem: Çalışmada farklı polikliniklere başvuran 7815 (1740 erkek ve 6075 kadın) hastanın verileri analiz edildi. Çalışma kriterlerini karşılayan ve HOMA-IR ile eGFR talep eden yetişkin hastalar hastane bilgi yönetim sistemi tarafından belirlendi. Tüm hastaların yaş ve cinsiyetleri tespit edildi. Veriler istatistiksel olarak değerlendirildi. İnsülin direnci; homeostatik model değerlendirme yöntemi ile ölçüldü.
Bulgular: Hastaların ortalama HOMA-IR ve eGFR değerleri sırasıyla 3.28±0.52 ve 111.35±22.91 olarak hesaplandı. 7815 hastanın %60’ının HOMA-IR değerleri normalden yüksek bulunurken, aynı hastaların eGFR değerleri normalden düşük olarak bulundu. HOMA-IR ile eGFR arasında negatif bir korelasyon tespit edildi (r = -0.48).
Sonuç: HOMA-IR ve eGFR arasındaki korelasyon (p<0.01) istatistiksel olarak anlamlı bulundu. Ancak, bu bilgilerin daha kapsamlı bir çalışma ile klinisyenler tarafından kullanılabilir hale getirilmesi önem arz edecektir. İnsulin direnci ve böbrek rahatsızlıklarının gelişimi ve takibinde HOMO_IR ve eGFR seviyelerinin değerlendirilmesi erken teşhis bakımından yardımcı olabilir.

Keywords

HOMA-IR, eGFR, Korelasyon

Correlation Between HOMA-IR and eGFR Values

Abstract

Objective: The aim of this study is to determine the correlation between the homeostatic model assessment of insulin resistance (HOMA-IR) values and the estimated glomerular filtration rate (eGFR) values of individuals who applied to different polyclinics of a training and research hospital with different complaints.
Materials and Methods: In the study, the data of 7815 (1740 men and 6075 women) patients who applied to different polyclinics were analyzed. Adult patients who met the study criteria and requested HOMA-IR and eGFR were identified by the hospital information management system. Age and gender of all patients were determined. The data were evaluated statistically. Insulin resistance; was measured by the homeostatic model evaluation method.
Results: The mean HOMA-IR and eGFR values of the patients were 3.28±0.52 and 111.35±22.91, respectively. While HOMA-IR values were found to be higher than normal in 60% of 7815 patients, the eGFR values of the same patients were found to be lower than normal. There was a moderate negative correlation between HOMA-IR and eGFR (r = -0.48). In other words, it was determined that patients with increased HOMA-IR values had a moderate decrease in eGFR values.
Conclusion: There was a moderate negative correlation between HOMA-IR and eGFR However, it will be important to make this information available to clinicians with a more detailed study. Evaluation of HOMO-IR and eGFR levels can be utility for early diagnosis in the development and follow up of insulin resistance and kidney disorders.

Keywords

Correlation, eGFR, HOMA-IR

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