Arda M., Minbay A., Aydın N., Akay Ö., İzgür M., Diker S. (1998). İmmunoloji. İkinci Baskı, Medisan Yayınevi, Ankara,127-164.
Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. (2001). CD4+CD25 high regulatory cells in human peripheral blood. The Journal of Immunology,167:1245–53.
Cooper M.A., Fehniger T.A., Turner S.C. (2001). Human natural killer cells: a unique innate immuno regulatory role for the CD56 (bright) subset. Blood Journal, 97(10): 3146-51.
Demiralp E.E. (2008). Hücre yüzey antijenleri (CD)’nin immunolojiye katkıları. Ankem, 22: 98-103.
Diker K.S. (1998). İmmunoloji. Birinci Baskı, Medisan Yayınevi, Ankara, 22-59.
Diker K.S. (2005). İmmunoloji. İkinci Baskı, Medisan Yayınevi, Ankara,1-26.
Fonseca J.E. (2002). Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ t lymphocyte-rich microenvironments. Arthritis Rheumatology, 46(5): 1210-6.
Gross J.A., Callas E., Allison J.P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology, 149: 380–8.
Horie R., Watanabe T. (1998). CD30: expression and function in health and disease. Seminars in Immunology,10: 457-70.
June C.H., Ledbetter J.A., Linsley P.S., Thompson C.B. (1990). Role of the CD28 receptor in T-cell activation. Immunology Today, 11: 211–6.
Kadin M.E. (2000). Regulation of CD30 antigen expression and its potential significance for human disease. American Journal of Pathology, 156:1479-84.
Klein U., Rajewsky K., Kuppers R. (1988). Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing CD27 Cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. The Journal of Experimental Medicine, 188:1679-89.
Kneiss S., Zhou Q., Schwenkert M., Cosset F.L., Verhoeyen E., Buchholz C.J. (2013). CD19 and CD20 targeted vectors ınduce minimal activation of resting B lymphocytes. Plos One, 8(11): 79047.
Law C.L., Sidorenko S.P., Chandran K.A, Zhao Z., Shen S.H., Fischer E.H., Clark E.A. (1996). CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. The Journal of Experimental Medicine, 183: 547–60.
Linsley P.S., Ledbetter J.A. (1993). The role of the CD28 receptor during T cell responses to antigen. Annual Review Immunology, 11: 191–212.
Madsen M., Moller H.J., Nielsen M.J., Jacobsen C., Graversen J.H., Vanden Berg T., Moestrup S.K. (2004). Molecular characterization of the haptoglobin.hemoglobin receptor CD163. ligand binding properties of the scavenger receptor cysteine-rich domain region. The Journal of Biological Chemistry, 279: 51561–67.
Nagler A., Lanier L.L., Cwirla S., Phillips J.H. (1989). Comparative studies of human FcRIII-positive and negative Natural Killer Cells. The Journal of Immunology, 143(10): 3183-91.
Nguyen T.T. (2005). Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. The American Journal of Surgical Pathology, 29(5): 617-24.
Osorio L.M., Rottenberg M., Jondal M., Chow S.C. (1998). Simultaneous cross-linking of CD6 and CD28 induces cell proliferationin resting T cells. Immunology, 93: 358-65.
Overdevest J.B., Thomas S., Kristiansen G., Hansel D.E., Smith S.C., Theodorescu D. (2011). CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization. Cancer Research,71(11): 3802–11.
Özdemirli M.(2004). B hücreli lenfomalarda morfolojik, immünolojik ve sitogenetik özellikler. XIII. TPOG Ulusal Pediatrik Kanser Kongresi, Non-Hodgkin Lenfoma. Mayıs, 18-22, Kapadokya-Türkiye.
Protein reviews on the web (PROW). http://mpr.nci.nih.gov/. (06.12.2013)
Reduta T., Stasiak-Barmuta A., Laudańska H. (2011). CD4+CD25+ and CD4+CD25high regulatory T cells in disseminated and localized forms of allergic contact dermatitis: relation to specific cytokines. Folıa Hıstochemica et Cytobiologica, 49: 255-62.
Reinherz E.L., Meuer S.C., Fıtzgerald K.A., Hussey R.E., Levmne H., Schlossman S.F. (1982). Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell, 30: 735-43.
Sahay B., Singh A., Gnanamani A., Patsey R.L., Blalock J.E., Sellati T.J. (2011). CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis. The American Journal of Pathology, 178(2): 724-34.
Seemiller A.C., Karankidar N.J., Kroft S.H., McKenna R.W., Xu Y. (2009). Overexpression of CD7 in classical Hodgkin Lymphoma-Infiltrating T lymphocytes. Cytometry Part B: Clinical Cytometry, 76 (3): 169–174.
Suzuki N. (1991). Evidence for the involvement of CD56 molecules in alloantigen specific recognition by human natural killer cells. The Journal of Experimental Medicine, 173: 1451–61.
Van Kooten C., Banchereau J. (2000). CD40-CD40 ligand. Journal of Leukocyte Biology, 67: 2–17. Veneri D., Ortolani R., Franchini M., Tridente G., Pizzolo G., Vella A. (2009). Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages. Journal Blood of Transfusion, 7: 29-34.
Wilson R.A., Zolnai A., Rudas P., Frenyol L.V. (1996). T cell subset in blood and lymphoid tisuue obtain from fetal calves, maturing calves and adult bovine. Vetherinary Immunology and Immunopathology, 53: 49-60.
Wu H., Gower R.M., Wang H., Perrard Y.D., Ma R.D., Bullard D.C., Burns A.R., Paul A., Smith C.W., Simon S.I., Ballantyne C.M. (2009). Functional role of CD11c monocytes in atherogenesis associated with hypercholesterolemia. Circulation, 119: 2708–17.
Wu J., Orr M.T., Fang M., Sigal L.J., Spee P., Egebjerg T., Dissen E., Fossum S., Phillips J.H., Lanier L.L. (2010). Development and function of CD94-deficient natural killer cells. Plos One, 5: e15184.
Yuan D., Keeble A.H., Hibbert R.G., Fabiane S., Gould H.J., McDonnell J.M., Beavil A.J., Sutton B.J., Dhaliwal B. (2013). Ca2+- dependent structural changes in the B-cell receptor CD23 ıncrease its affinity for human ımmunoglobulin E. The Journal of Biological Chemistry, 288: 21667-77.
Zhao L., Moos M.P., Grabner R., Pedrono F., Fan J., Kaiser B., John N., Schmidt S., Spanbroek R., Lotzer K., Huang L., Cui J., Rader D.J., Evans J.F., Habenicht A.J., Funk C.D. (2004). The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia dependent aortic aneurysm. Nature Medicine, 10: 966–73.
Zola H., Swart B. (2003). Human leucocyte differentiation antigens. Trends in Immunology, 24(7): 353-4.
Zola H., Swart B., Banham A. (2007). CD molecules 2006-human cell differentiation molecules. Journal of Immunological Methods, 319(1-2): 1-5.
İmmun Sistem Hücrelerinde CD Molekülleri
Year 2017,
Volume: 10 Issue: 2, 206 - 214, 31.12.2017
Özet: Bağışıklık
sistemi; yani organizmanın dış etkenlere karşı savunulması canlılığın devamının
sağlanması için önemli ve gerekli bir sistemdir. Bağışıklık sistemi hücreleri
ve antijenler arasındaki etkileşimler lenfositlerin yüzeyinde bulunan
reseptörler aracılığı ile gerçekleştirilir. Bu reseptörler antijeni tanıma
birimleri olarak özelleşmiş hücre yüzey reseptörleri olarak adlandırılmaktadır.
Günümüzde yapılan çalışmalar ile birçok hücre yüzey molekülü olduğu
belirlenmiştir. Bunlardan biri de Cluster of Differentiation (Yüzey farklılaşma
antijenleri(CD)) molekülleridir. CD
isimlendirmesi tüm dünyada kabul gören bir yöntemdir ve CD molekülleri birçok
hastalığın tanı ve tedavisinde de kullanılmaktadır. Bu derlemede immun sistem
hücrelerinde bulunan CD molekülleri hakkında bilgi verilmiştir.
Arda M., Minbay A., Aydın N., Akay Ö., İzgür M., Diker S. (1998). İmmunoloji. İkinci Baskı, Medisan Yayınevi, Ankara,127-164.
Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. (2001). CD4+CD25 high regulatory cells in human peripheral blood. The Journal of Immunology,167:1245–53.
Cooper M.A., Fehniger T.A., Turner S.C. (2001). Human natural killer cells: a unique innate immuno regulatory role for the CD56 (bright) subset. Blood Journal, 97(10): 3146-51.
Demiralp E.E. (2008). Hücre yüzey antijenleri (CD)’nin immunolojiye katkıları. Ankem, 22: 98-103.
Diker K.S. (1998). İmmunoloji. Birinci Baskı, Medisan Yayınevi, Ankara, 22-59.
Diker K.S. (2005). İmmunoloji. İkinci Baskı, Medisan Yayınevi, Ankara,1-26.
Fonseca J.E. (2002). Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ t lymphocyte-rich microenvironments. Arthritis Rheumatology, 46(5): 1210-6.
Gross J.A., Callas E., Allison J.P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology, 149: 380–8.
Horie R., Watanabe T. (1998). CD30: expression and function in health and disease. Seminars in Immunology,10: 457-70.
June C.H., Ledbetter J.A., Linsley P.S., Thompson C.B. (1990). Role of the CD28 receptor in T-cell activation. Immunology Today, 11: 211–6.
Kadin M.E. (2000). Regulation of CD30 antigen expression and its potential significance for human disease. American Journal of Pathology, 156:1479-84.
Klein U., Rajewsky K., Kuppers R. (1988). Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing CD27 Cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. The Journal of Experimental Medicine, 188:1679-89.
Kneiss S., Zhou Q., Schwenkert M., Cosset F.L., Verhoeyen E., Buchholz C.J. (2013). CD19 and CD20 targeted vectors ınduce minimal activation of resting B lymphocytes. Plos One, 8(11): 79047.
Law C.L., Sidorenko S.P., Chandran K.A, Zhao Z., Shen S.H., Fischer E.H., Clark E.A. (1996). CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. The Journal of Experimental Medicine, 183: 547–60.
Linsley P.S., Ledbetter J.A. (1993). The role of the CD28 receptor during T cell responses to antigen. Annual Review Immunology, 11: 191–212.
Madsen M., Moller H.J., Nielsen M.J., Jacobsen C., Graversen J.H., Vanden Berg T., Moestrup S.K. (2004). Molecular characterization of the haptoglobin.hemoglobin receptor CD163. ligand binding properties of the scavenger receptor cysteine-rich domain region. The Journal of Biological Chemistry, 279: 51561–67.
Nagler A., Lanier L.L., Cwirla S., Phillips J.H. (1989). Comparative studies of human FcRIII-positive and negative Natural Killer Cells. The Journal of Immunology, 143(10): 3183-91.
Nguyen T.T. (2005). Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. The American Journal of Surgical Pathology, 29(5): 617-24.
Osorio L.M., Rottenberg M., Jondal M., Chow S.C. (1998). Simultaneous cross-linking of CD6 and CD28 induces cell proliferationin resting T cells. Immunology, 93: 358-65.
Overdevest J.B., Thomas S., Kristiansen G., Hansel D.E., Smith S.C., Theodorescu D. (2011). CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization. Cancer Research,71(11): 3802–11.
Özdemirli M.(2004). B hücreli lenfomalarda morfolojik, immünolojik ve sitogenetik özellikler. XIII. TPOG Ulusal Pediatrik Kanser Kongresi, Non-Hodgkin Lenfoma. Mayıs, 18-22, Kapadokya-Türkiye.
Protein reviews on the web (PROW). http://mpr.nci.nih.gov/. (06.12.2013)
Reduta T., Stasiak-Barmuta A., Laudańska H. (2011). CD4+CD25+ and CD4+CD25high regulatory T cells in disseminated and localized forms of allergic contact dermatitis: relation to specific cytokines. Folıa Hıstochemica et Cytobiologica, 49: 255-62.
Reinherz E.L., Meuer S.C., Fıtzgerald K.A., Hussey R.E., Levmne H., Schlossman S.F. (1982). Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell, 30: 735-43.
Sahay B., Singh A., Gnanamani A., Patsey R.L., Blalock J.E., Sellati T.J. (2011). CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis. The American Journal of Pathology, 178(2): 724-34.
Seemiller A.C., Karankidar N.J., Kroft S.H., McKenna R.W., Xu Y. (2009). Overexpression of CD7 in classical Hodgkin Lymphoma-Infiltrating T lymphocytes. Cytometry Part B: Clinical Cytometry, 76 (3): 169–174.
Suzuki N. (1991). Evidence for the involvement of CD56 molecules in alloantigen specific recognition by human natural killer cells. The Journal of Experimental Medicine, 173: 1451–61.
Van Kooten C., Banchereau J. (2000). CD40-CD40 ligand. Journal of Leukocyte Biology, 67: 2–17. Veneri D., Ortolani R., Franchini M., Tridente G., Pizzolo G., Vella A. (2009). Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages. Journal Blood of Transfusion, 7: 29-34.
Wilson R.A., Zolnai A., Rudas P., Frenyol L.V. (1996). T cell subset in blood and lymphoid tisuue obtain from fetal calves, maturing calves and adult bovine. Vetherinary Immunology and Immunopathology, 53: 49-60.
Wu H., Gower R.M., Wang H., Perrard Y.D., Ma R.D., Bullard D.C., Burns A.R., Paul A., Smith C.W., Simon S.I., Ballantyne C.M. (2009). Functional role of CD11c monocytes in atherogenesis associated with hypercholesterolemia. Circulation, 119: 2708–17.
Wu J., Orr M.T., Fang M., Sigal L.J., Spee P., Egebjerg T., Dissen E., Fossum S., Phillips J.H., Lanier L.L. (2010). Development and function of CD94-deficient natural killer cells. Plos One, 5: e15184.
Yuan D., Keeble A.H., Hibbert R.G., Fabiane S., Gould H.J., McDonnell J.M., Beavil A.J., Sutton B.J., Dhaliwal B. (2013). Ca2+- dependent structural changes in the B-cell receptor CD23 ıncrease its affinity for human ımmunoglobulin E. The Journal of Biological Chemistry, 288: 21667-77.
Zhao L., Moos M.P., Grabner R., Pedrono F., Fan J., Kaiser B., John N., Schmidt S., Spanbroek R., Lotzer K., Huang L., Cui J., Rader D.J., Evans J.F., Habenicht A.J., Funk C.D. (2004). The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia dependent aortic aneurysm. Nature Medicine, 10: 966–73.
Zola H., Swart B. (2003). Human leucocyte differentiation antigens. Trends in Immunology, 24(7): 353-4.
Zola H., Swart B., Banham A. (2007). CD molecules 2006-human cell differentiation molecules. Journal of Immunological Methods, 319(1-2): 1-5.
Yediel Aras, Ş., & Karadağ Sarı, E. (2017). İmmun Sistem Hücrelerinde CD Molekülleri. Kafkas Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 10(2), 206-214.