Üreme Döneminde Kadınlarda TSH Düzeyinin Yumurta Rezervine Etkisi

Year 2020, Volume: 22 Issue: 3, 370 - 376, 31.12.2020

Taner Demirci , Mahmut Apaydın

https://doi.org/10.24938/kutfd.809017

Cited By: 1

Abstract

Amaç: Üreme çağındaki kadınlarda en sık görülen endokrinolojik bozukluklardan biri tiroid hastalıklarıdır. Serum Anti-Mullerian hormon düzeyinin yumurtalık düzeyini belirlemede iyi bir gösterge olduğu bilinmektedir. Bu çalışmada, serum tiroid uyarıcı hormon düzeyinin Anti-Mullerian hormon üzerindeki etkisini araştırdık.

Gereç ve Yöntemler: Endokrinoloji kliniğine fertilite değerlendirmesi için konsülte edilen 20-45 yaş arası 198 hastanın verileri kaydedildi ve geriye dönük olarak incelendi. Tüm hastalar TSH sonuçlarına göre 3 kategoriye ayrıldı; 1) ≤2.5 mIU / L, 2) 2.51-4.99 mIU / L, 3) ≥5 mIU / L. Tüm bu gruplar arasında serum Anti-Mullerian hormon, laboratuvar sonuçları ve demografik özellikler karşılaştırıldı. Ayrıca, Anti-Mullerian hormon ile tiroid uyarıcı hormon arasındaki korelasyon ilişkisi analiz edildi.

Bulgular: Hastaların ortalama yaşı 29.4 (±6.4) idi. Yaş (p=0.384), vücut kitle indeksi (p=0.407), follikül stimüle edici hormon (p=0.178), luteinizan hormon (p=0.407), östradiol (p=0.424) ve Anti-Mullerian hormon (p=0.814) gibi değişkenler gruplar arasında farklı değildi. Serum Anti-Mullerian hormon seviyesi ile serum tiroid uyarıcı hormon seviyesi veya vücut kitle indeksi sonuçları arasında korelasyon ilişkisi yoktu. Anti-Mullerian hormon ve luteinizan hormon (r=0.258, p=0.001) arasında istatistiksel olarak anlamlı düzeyde pozitif korelasyon bulunurken, Anti-Mullerian hormon ile follikül stimüle edici hormon (r=-0.207, p=0.007) ve estradiol (r=-0.198, p=0.010) arasında negatif korelasyon tespit edildi.

Sonuç: Sonuç olarak, hafif tiroid uyarıcı hormon değişiklikleri yumurtalık rezervinin değerlendirilmesinde kullanılan Anti-Mullerian hormon üzerinde etkili görünmemekle birlikte, yumurtalık rezervinin tiroid hormon replasman tedavisi ile olumlu yönde değiştiğini göstermek için daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

Anti-Mullerian Hormon, TSH, yumurtalık rezervi

THE EFFECT OF TSH LEVEL ON OVARIAN RESERVE IN WOMEN IN THE REPRODUCTIVE PERIOD

Abstract

Objective: One of the most common endocrinological disorders in women of reproductive age is thyroid diseases. It is known that serum Anti-Mullerian hormone level is a good indicator in determining the ovarian reserve. In this study, we investigated the effect of serum thyroid-stimulating hormone level on Anti-Mullerian hormone.

Material and Methods: The data of 198 patients aged between 20-45 years, who were consulted to the endocrinology clinic for fertility evaluation, were recorded and analyzed retrospectively. All patients were divided into 3 categories according to their thyroid-stimulating hormone level results; 1) ≤2.5 mIU/L, 2) 2.51-4.99 mIU/L, 3) ≥5 mIU/L. Serum Anti-Mullerian hormone, laboratory results and demographic characteristics were compared between all of the groups. In addition, the correlation between Anti-Mullerian hormone and thyroid-stimulating hormone was analyzed.

Results: The mean age of the patients was 29.4 (±6.4). Variables such as age (p=0.384), BMI (p=0.407), FSH (p=0.178), LH (p=0.407), estradiol (p=0.424), and Anti-Mullerian hormone (p=0.814) were not different between the groups. There was no correlation between Anti-Mullerian hormone level and serum thyroid-stimulating hormone level or body mass index results. While a statistically significant positive correlation was found between Anti-Mullerian hormone and luteinizing hormone (r=0.258, p=0.001), a negative correlation was found between Anti-Mullerian hormone and follicle stimulating hormone (r=-0.207, p=0.007) and estradiol (r=-0.198, p=0.010).

Conclusion: In conclusion, while mild thyroid-stimulating hormone changes do not appear to be effective on Anti-Mullerian hormone used in the assessment of ovarian reserve, more comprehensive studies are needed to show that ovarian reserve changes positively with thyroid hormone replacement therapy.

Keywords

Anti-Mullerian Hormone, TSH, ovarian reserve

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