Hematologic Inflammatory Markers in the Retrospective Evaluation of Cases with A Pathologic Diagnosis of Uterine Fibroid

Year 2021, Volume: 23 Issue: 1, 11 - 18, 30.04.2021

Melike Demir Çaltekin , Taylan Onat , Demet Aydoğan Kırmızı , Emre Başer , Ayla Gençer Mustafa Kara , Ethem Serdar Yalvaç

https://doi.org/10.24938/kutfd.768553

Abstract

Objective: The patients with a postoperative pathologic diagnosis of uterine leiomyoma were evaluated in terms of surgical procedure, fibroid features and accompanying pathologies. We also wanted to reveal the relationship of inflammatory markers with the number, size and localization of fibroids.

Material and Methods: The data of 102 patients with a postoperative pathologic diagnosis of uterine leiomyoma were assessed retrospectively. Age, gravida, parity, preoperative and postoperative hemogram results of patients were obtained from the patients’ files. Fibroid size, number, location and other gyneco-pathologies accompanying myoma were obtained from the pathology reports.

Results: When the fibroid localization was examined, it was determined that 44.1%of the fibroids showed intramural location, and at least 2 fibroids were detected 61%of the patients. Retrospective review of the surgical procedures performed showed that total abdominal hysterectomy was performed in 46%of the patients. For the relationship between inflammatory parameters and fibroid size; neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio values were found to be statistically different (p= 0.023; 0.038 respectively), however, platelet/lymphocyte ratio values were statistically insignificant (p˃0.05). There was no statistically significant difference between the preoperative and postoperative hemoglobin values of the cases examined in terms of both fibroid size and number (p˃0.05).

Conclusion: While a decrease in lymphocyte/monocyte ratio is observed with increased number of fibroids, there is an increase in neutrophil/lymphocyte ratio and a decrease in lymphocyte/monocyte ratio with an increase in myoma size.

Keywords

Leiomyoma, inflammation, lymphocyte/monocyte ratio, hysterectomy

PATOLOJİ SONUCU UTERİN LEİOMYOM OLARAK SONUÇLANAN OLGULARIN HEMATOLOJİK İNFLAMATUAR BELİRTEÇLER İLE RETROSPEKTİF DEĞERLENDİRİLMESİ

Abstract

Amaç: Patoloji sonucu uterin leiomyom olarak sonuçlanan vakaların, yapılan cerrahi işlem, myom özellikleri ve eşlik eden patolojiler açısından değerlendirilmesi hedeflenmiştir. Ayrıca; myom sayısı, büyüklüğü ve lokalizasyonuna göre inflamatuar belirteçlerin de değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Cerrahi sonrası patoloji sonucu uterin leiomyom olarak değerlendirilen 102 hastanın verileri retrospektif olarak değerlendirildi. Olguların yaş, gravida, parite, preoperatif ve postoperatif hemogram sonuçlarına hasta dosyalarından ulaşıldı. Myoma eşlik eden diğer jineko-patolojiler, myom boyutu, sayısı ve yerleşimi bilgilerine patoloji raporlarından ulaşıldı.

Bulgular: Myom yerleşimi incelendiğinde olguların %44.1’inin intramural yerleşim gösterdiği, myom sayısına bakıldığında ise hastaların %61’ inde en az iki adet myom olduğu saptandı. Hastalara yapılan cerrahi işlemler retrospektif değerlendirildiğinde olguların %46’sına total abdominal histerektomi yapıldığı görüldü. İnflamatuar parametrelerle myom büyüklüğü arasındaki ilişki incelendiğinde; ≤5 cm ile ˃5 cm myomu olan olgular karşılaştırıldığında nötrofil/lenfosit oranı ve lenfosit/monosit oranı değerleri istatistiksel olarak anlamlı farklı bulundu (sırasıyla, p=0.023; 0.038), ancak platelet/lenfosit oranı değerleri istatistiksel olarak anlamsız bulundu (p˃0.05). Hem myom boyutu hem de sayısı açısından incelenen olguların preoperatif ve postoperatif hemoglobin değerleri arasında istatistiksel olarak bir farklılık saptanmadı (p˃0.05).

Sonuç: Artmış myom sayısı ile lenfosit/monosit oranında azalma gözlenirken, myom boyutu artışıyla nötrofil/lenfosit oranında artış ve lenfosit/monosit oranında da azalma olmaktadır.

Keywords

leiomyom, histerektomi, lenfosit/monosit oranı, inflamasyon

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