THE EFFECTS OF EXENATIDE TREATMENT ON METABOLIC PARAMETERS, GHRELIN, GDF-15 AND FGF-21 IN OBESE TYPE 2 DIABETIC PATIENTS

Year 2022, Volume: 24 Issue: 1, 110 - 117, 30.04.2022

Müge Özsan Yılmaz , Oğuzhan Özcan

https://doi.org/10.24938/kutfd.1014625

Abstract

Objective: Exenatide and similar drugs which have Glucagon Like Peptide-1(GLP-1) like effects have been used frequently in the treatment of diabetes and obesity in recent years. In this study we aimed to investigate the effects of exenatide on ghrelin, FGF-21 and GDF-15 which are known to be associated with appetite and metabolic disorders.

Material and Methods: Thirty patients with Type 2 Diabetes Mellitus with a Body Mass Index of 35 kg/m2 and above who are still ongoing treatment for diabetes but not on target (HbA1c>7%) and exenatide treatment was started were included in the study. Venous blood samples were collected for the measurements of complete blood count, biochemical parameters, HbA1c, ghrelin, FGF-21, GDF-15. After 3 months of treatment initial evaluations and biochemical tests were repeated.

Results: Mean age of the patients was 50.43±10.35 years. Twenty-one (70%) were female and 9 (30%) were male. Mean Hb A1c of the patients was 9.68±2.02%. After 3 months of exenatide treatment a significant decrease in body weight and body mass index was observed (p<0.001). There was also significant decrease in Ghrelin and GDF-15 levels (p<0.001).

Conclusion: Our study is the first study in which these three markers were evaluated together in obese type 2 diabetics. It is thought to be that Ghrelin, FGF-21 and GDF-15 are play role in obesity and type 2 diabetes mellitus pathogenesis together in different ways.

Keywords

obesity, exenatide, ghrelin, Fibroblast Growth Factor 21, Growth Differentiation Factor 15

Obez Tip 2 Diyabetik Hastalarda Eksenatid Tedavisinin Metabolik Parametreler, Ghrelin, GDF-15 ve FGF-21 Üzerine Etkileri

Abstract

Amaç: Glukagon Benzeri Peptid-1(GLP-1) benzeri etkileri olan eksenatid ve benzeri ilaçlar son yıllarda diyabet ve obezite tedavisinde sıklıkla kullanılmaktadır. Bu çalışmada eksenatidin iştah ve metabolik bozukluklarla ilişkili olduğu bilinen hormonal özellikli peptidler olan ghrelin, FGF-21 ve GDF-15 üzerine etkilerini araştırmayı amaçladık.

Gereç ve Yöntemler: Tip 2 Diabetes Mellitus'lu, Vücut Kitle İndeksi 35 kg/m2 ve üzerinde olan, diyabet tedavisi devam eden ancak hedefte olmayan (Hb A1c>%7) ve eksenatid tedavisi başlanan 30 hasta çalışmaya dahil edildi. Tam kan sayımı, biyokimyasal parametreler, HbA1c, ghrelin, FGF-21, GDF-15 ölçümleri için venöz kan örnekleri alındı. 3 aylık tedaviden sonra ilk değerlendirmeler ve biyokimyasal testler tekrarlandı.

Bulgular: Hastaların yaş ortalaması 50.43±10.35 yıl olup; 21’i (%70) kadın, 9’u (%30) erkekti. Hastaların ortalama Hb A1c’si %9.68±2.02 idi. Eksenatid tedavisinden sonra vücut ağırlığında ve vücut kitle indeksinde önemli bir azalma gözlendi (p<0.001). Ghrelin ve GDF-15 düzeylerinde de anlamlı düşüş vardı (p<0.001).

Sonuç: Çalışmamız, obez tip 2 diyabetlilerde bu üç belirtecin birlikte değerlendirildiği ilk çalışmadır. Ghrelin, FGF-21 ve GDF-15'in obezite ve tip 2 diabetes mellitus patogenezinde birlikte farklı şekillerde rol oynadığı düşünülmektedir.

Keywords

obezite, eksenatid, ghrelin, Fibroblast Büyüme Faktörü 21, Büyüme Farklılaşma Faktörü 15

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