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Pırlak Bir Kuzuda Otosefali ile Birlikte Gözlenen Siklopiya Olgusu

Year 2016, Volume: 9 Issue: 4, 379 - 382, 01.12.2016

Abstract

Bu raporda Pırlak ırkı bir dişi kuzuda ruminantlarda daha önceden rapor edilmeyen otosefali ile beraber gözlenen siklopi olgusu sunuldu. İki yaşında olan nullipar Pırlak ırkı bir koyun güç doğum sebebiyle Afyon Kocatepe Üniversitesi, Veteriner Fakültesi kliniklerine getirildi. Koyuna sezaryen operasyonu uygulandı ve ölü bir dişi kuzu uterustan çıkartıldı. Plasental bölgelerde plasentomlar sayıca az ve çapları küçük olarak belirlendi. Kuzuya yapılan morfolojik ve makroskobik muayenelerde hayvanın baş bölgesinde özellikle siklopi ve otosefali olmak üzere bazı anomalilerin olduğu belirlenirken, diğer vücut bölümlerinde herhangi bir anomaliye rastlanılmadı. Bunu yanı sıra tam bir ağız boşluğunun olmadığı, maksillar ve mandibular kemiklerin, dişlerin (dysgnathia), burunun (arhinia) ve dilin oluşmadığı (aglossia) gözlendi. Ayrıca, farinkse, özofagusa ve trakeyaya (microstomia) açılan ve tek göz açıklığının alt kısmında küçük bir delik belirlendi. Bu küçük deliğin her iki tarafında sağ ve sol kulak kepçelerinin birbirine yapışık olduğu gözlendi (synotia). Nekropside beynin anormal yapıda, çok küçük ve ödematöz olduğu, beyin loblarının ve giruslarının bulunmadığı tespit edildi. Torasik, abdominal ve pelvik boşlukların muayenesinde bir anormalliğe rastlanmadı.

References

  • Basher E. Clinical study on fetal congenital defects causing dystocia in Awassi ewes. Iraqi J. Vet. Sci. 2006; 20(2):181-189.
  • Brachthäuser L, Klumpp S, Hecht W, Kuchelmeister K, Reinacher M, Ebbert W, Herden C. Aprosencephaly with otocephaly in a lamb (Ovisaries). Vet Pathol. 2012; 49(6):1043-1048.
  • Challis JR, Sloboda D, Matthews SG, Holloway A, Alfaidy N, Patel FA, Whittle W, Fraser M, Moss TJ, Newnham J. The fetal placental hypothalamic-pituitary adrenal (HPA) axis, parturition and post natal health. Mol Cell Endocrinol. 2001; 185(1-2):135-144.
  • Eftekhari Z, Mokhber Dezfouli MR, Toghroli R. An unusual cyclops kid associated with a normal twin from Kerman Province. Comp Clin Pathol. 2013; 22:507–508.
  • Faye-Petersen O, David E, Rangwala N, Seaman JP, Hua Z, Heller DS. Otocephaly: report of five new cases and a literature review. Fetal Pediatr Pathol. 2006; 25(5):277-296.
  • Gekas J, Li B, Kamnasaran D. Current perspectives on the etiology of agnathia-otocephaly. Eur J Med Genet. 2010; 53(6):358-366.
  • Givens MD, Marley MS. Infectious causes of embryonic and fetal mortality. Theriogenology. 2008; 70(3):270-285.
  • Gondré-Lewis MC, Gboluaje T, Reid SN, Lin S, Wang P, Green W, Diogo R, Fidélia-Lambert MN, Herman MM. The human brain and face: mechanisms of cranial, neurological and facial development revealed through malformations of holoprosencephaly, cyclopia and aberrations in chromosome 18. J Anat. 2015; 227(3):255-267.
  • Hamali H, Chador Shabi N. First report of a cyclops lamb associated with a normal twin lamb from Iran. Iran J Vet Sci Technol. 2010; 2(2):117–122.
  • Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development. 1998; 125(18):3553-3562.
  • Karan M, Üstündağ Y, Aydin M. Saanen Irkı Bir Oğlakta Rastlanılan Cyclopia, Arhinia ve Hermafroditizm Olgusu. Kafkas Uni. Vet. Fak. Derg. 2011; 17(1):147-150.
  • Ozcan K, Gurbulak K, Takçi I, Ozen H, Kacar C, Pancarcı MS. Atypical Cyclopia in a Brown Swiss Cross Calf: A Case Report. Anat. Histol. Embryol. 2006; 35:152–154.
  • Pawaiya RVS, Gupta VK. A review on Schmallenberg virus infection: a newly emerging disease of cattle, sheep and goats. Veterinarni Medicina. 2013; 58(10):516–526.
  • Pourlis AF. Spontaneous agnathia-otocephaly in a lamb of the Chiotiko breed a case report. Veterinarski Arhiv. 2008; 78 (5):449-456.
  • Sankar P, Kokila S, Gopal K. Microcephaly in a Lamb- A case report. Shanlax Int. J. of Vet. Sci. 2014; 1(4):38-39.
  • Schiffer C, Tariverdian G, Schiesser M, Thomas MC, Sergi C. Agnathia otocephaly complex: report of three cases with involvement of two different Carnegie stages. Am J Med Genet. 2002; 112(2):203-208.
  • Sutaria TV, Sutaria PT, Patel JS, Chauhan PM. An unusual case of cyclopic and arhinia monster in Mehsana buffalo. Vet. World. 2012; 5(7):429-430.
  • Tonk RK, Yadav BR, Yadav AS, Raju S, Tomer KPS, Mohanty TK. Zebu cattle calf (sahiwal breed) with multiple muscolo skeletal congenital defects. Indian J. Vet. Res. 2010; 19(2):13-21.
  • Welch KD, Panter KE, Lee ST, Gardner DR, Stegelmeier BL, Cook D. Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation. J Appl Toxicol. 2009; 29(5):414-421.
  • Welch KD, Panter KE, Stegelmeier BL, Lee ST, Gardner DR, Cook D. Veratrum-Induced Placental Dysplasia in Sheep. IJPPR. 2012; 2:54-62.

A Cyclopia Case with Otocephaly in a Pirlak Lamb

Year 2016, Volume: 9 Issue: 4, 379 - 382, 01.12.2016

Abstract

In this report, a case of cyclopia with otocephaly in a Pirlak lamb was presented which has not been reported previosly in ruminants. A two years old-nulliparous Pirlak ewe was referred to the clinics of Afyon Kocatepe University, Faculty of Veterinary Medicine with the complaint of dystocia. Cesarean section was performed and a dead female lamb was extracted out from the uterus. The number and size of placentomes were reduced at the placental sites. Morphologic and macroscopic examination of the lamb demonstrated that there were some congenital anomalies, especially an eye (cyclopia) and otocephaly, at the head of lamb, however no other anomalies were defined at the other parts of body. On the other hand there were no whole mouth space, maxillar and mandibular bones, teeth (dysgnathia), no nose (arhinia) and tongue (aglossia). Nevertheless, there was a small hole at the bottom of the one eye opening to pharynx, oesophagus and trachea (microstomia). The left and right auricles were adherent together on the both sides of the small hole (synotia). At necropsy, the brain was not normal, rather small and edematous, having any brain lobes and gyrus. Examination of thoracic, abdominal and pelvic spaces revealed no abnormality.

References

  • Basher E. Clinical study on fetal congenital defects causing dystocia in Awassi ewes. Iraqi J. Vet. Sci. 2006; 20(2):181-189.
  • Brachthäuser L, Klumpp S, Hecht W, Kuchelmeister K, Reinacher M, Ebbert W, Herden C. Aprosencephaly with otocephaly in a lamb (Ovisaries). Vet Pathol. 2012; 49(6):1043-1048.
  • Challis JR, Sloboda D, Matthews SG, Holloway A, Alfaidy N, Patel FA, Whittle W, Fraser M, Moss TJ, Newnham J. The fetal placental hypothalamic-pituitary adrenal (HPA) axis, parturition and post natal health. Mol Cell Endocrinol. 2001; 185(1-2):135-144.
  • Eftekhari Z, Mokhber Dezfouli MR, Toghroli R. An unusual cyclops kid associated with a normal twin from Kerman Province. Comp Clin Pathol. 2013; 22:507–508.
  • Faye-Petersen O, David E, Rangwala N, Seaman JP, Hua Z, Heller DS. Otocephaly: report of five new cases and a literature review. Fetal Pediatr Pathol. 2006; 25(5):277-296.
  • Gekas J, Li B, Kamnasaran D. Current perspectives on the etiology of agnathia-otocephaly. Eur J Med Genet. 2010; 53(6):358-366.
  • Givens MD, Marley MS. Infectious causes of embryonic and fetal mortality. Theriogenology. 2008; 70(3):270-285.
  • Gondré-Lewis MC, Gboluaje T, Reid SN, Lin S, Wang P, Green W, Diogo R, Fidélia-Lambert MN, Herman MM. The human brain and face: mechanisms of cranial, neurological and facial development revealed through malformations of holoprosencephaly, cyclopia and aberrations in chromosome 18. J Anat. 2015; 227(3):255-267.
  • Hamali H, Chador Shabi N. First report of a cyclops lamb associated with a normal twin lamb from Iran. Iran J Vet Sci Technol. 2010; 2(2):117–122.
  • Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development. 1998; 125(18):3553-3562.
  • Karan M, Üstündağ Y, Aydin M. Saanen Irkı Bir Oğlakta Rastlanılan Cyclopia, Arhinia ve Hermafroditizm Olgusu. Kafkas Uni. Vet. Fak. Derg. 2011; 17(1):147-150.
  • Ozcan K, Gurbulak K, Takçi I, Ozen H, Kacar C, Pancarcı MS. Atypical Cyclopia in a Brown Swiss Cross Calf: A Case Report. Anat. Histol. Embryol. 2006; 35:152–154.
  • Pawaiya RVS, Gupta VK. A review on Schmallenberg virus infection: a newly emerging disease of cattle, sheep and goats. Veterinarni Medicina. 2013; 58(10):516–526.
  • Pourlis AF. Spontaneous agnathia-otocephaly in a lamb of the Chiotiko breed a case report. Veterinarski Arhiv. 2008; 78 (5):449-456.
  • Sankar P, Kokila S, Gopal K. Microcephaly in a Lamb- A case report. Shanlax Int. J. of Vet. Sci. 2014; 1(4):38-39.
  • Schiffer C, Tariverdian G, Schiesser M, Thomas MC, Sergi C. Agnathia otocephaly complex: report of three cases with involvement of two different Carnegie stages. Am J Med Genet. 2002; 112(2):203-208.
  • Sutaria TV, Sutaria PT, Patel JS, Chauhan PM. An unusual case of cyclopic and arhinia monster in Mehsana buffalo. Vet. World. 2012; 5(7):429-430.
  • Tonk RK, Yadav BR, Yadav AS, Raju S, Tomer KPS, Mohanty TK. Zebu cattle calf (sahiwal breed) with multiple muscolo skeletal congenital defects. Indian J. Vet. Res. 2010; 19(2):13-21.
  • Welch KD, Panter KE, Lee ST, Gardner DR, Stegelmeier BL, Cook D. Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation. J Appl Toxicol. 2009; 29(5):414-421.
  • Welch KD, Panter KE, Stegelmeier BL, Lee ST, Gardner DR, Cook D. Veratrum-Induced Placental Dysplasia in Sheep. IJPPR. 2012; 2:54-62.
There are 20 citations in total.

Details

Journal Section CASE REPORT
Authors

Muhammed Kürşat Birdane

Oktay Yılmaz This is me

Mehmet Uçar This is me

Publication Date December 1, 2016
Acceptance Date October 18, 2016
Published in Issue Year 2016 Volume: 9 Issue: 4

Cite

APA Birdane, M. K., Yılmaz, O., & Uçar, M. (2016). A Cyclopia Case with Otocephaly in a Pirlak Lamb. Kocatepe Veterinary Journal, 9(4), 379-382.
AMA Birdane MK, Yılmaz O, Uçar M. A Cyclopia Case with Otocephaly in a Pirlak Lamb. kvj. December 2016;9(4):379-382.
Chicago Birdane, Muhammed Kürşat, Oktay Yılmaz, and Mehmet Uçar. “A Cyclopia Case With Otocephaly in a Pirlak Lamb”. Kocatepe Veterinary Journal 9, no. 4 (December 2016): 379-82.
EndNote Birdane MK, Yılmaz O, Uçar M (December 1, 2016) A Cyclopia Case with Otocephaly in a Pirlak Lamb. Kocatepe Veterinary Journal 9 4 379–382.
IEEE M. K. Birdane, O. Yılmaz, and M. Uçar, “A Cyclopia Case with Otocephaly in a Pirlak Lamb”, kvj, vol. 9, no. 4, pp. 379–382, 2016.
ISNAD Birdane, Muhammed Kürşat et al. “A Cyclopia Case With Otocephaly in a Pirlak Lamb”. Kocatepe Veterinary Journal 9/4 (December 2016), 379-382.
JAMA Birdane MK, Yılmaz O, Uçar M. A Cyclopia Case with Otocephaly in a Pirlak Lamb. kvj. 2016;9:379–382.
MLA Birdane, Muhammed Kürşat et al. “A Cyclopia Case With Otocephaly in a Pirlak Lamb”. Kocatepe Veterinary Journal, vol. 9, no. 4, 2016, pp. 379-82.
Vancouver Birdane MK, Yılmaz O, Uçar M. A Cyclopia Case with Otocephaly in a Pirlak Lamb. kvj. 2016;9(4):379-82.

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