Effects of Dietary Chromium on Immune System
Year 2017,
Volume: 10 Issue: 2, 99 - 105, 01.03.2017
Eyüp Eren Gültepe
,
Cangir Uyarlar
İsmail Bayram
Abstract
Many studies were conducted on chromium (Cr) nutrition. Since earlier, Cr was accepted as an essential nutrient/mineral. Also, close relationship between dietary Cr and carbohydrate metabolism was revealed in detail. Although some effects of dietary Cr on immune response were revealed by earlier in vitro studies, interests on farm-based effects have been recently focused. In this review, the effects of dietary Cr on immune system have been emphasized.
References
- Abraham AS, Sonnenblick M, Eini M. The effect
of chromium on cholesterol-induced
atherosclerosis in rabbits. Atherosclerosis.
1982a;41(2–3): 371–9.
- Abraham AS, Sonnenblick M, Eini M. The action
of chromium on serum lipids and on
atherosclerosis in cholesterol-fed rabbits.
Atherosclerosis. 1982b;42(2–3): 185–95.
- Anderson RA, Bryden NA, Polansky MM,
Deuster PA. Exercise effects on chromium
excretion of trained and untrained men
consuming a constant diet. J. Appl. Physiol.
1988;64(1): 249–52.
- Anderson RA, Polansky MM, Bryden NA,
Roginski EE, Patterson KY, Reamer DC.
Effect of Exercise (Running) on Serum
Glucose, Insulin, Glucagon, and Chromium
Excretion. Diabetes. 1982;31(3): 212–6.
- Arthington JD, Corah LR, Minton JE, Elsasser
TH, Blecha F. Supplemental Dietary
Chromium Does Not Influence ACTH,
Cortisol, or Immune Responses in Young
Calves Inoculated with Bovine Herpesvirus-1.
J. Anim. Sci. 1997;75(1): 217–23.
- Burton JL, Mallard BA, Mowat DN. Effects of
supplemental chromium on immune
responses of periparturient and early lactation
dairy cows. J. Anim. Sci. 1993;71(6): 1532–9.
- Burton JL, Mallard BA, Mowat DN. Effects of
supplemental chromium on antibody
responses of newly weaned feedlot calves to
immunization with infectious bovine
rhinotracheitis and parainfluenza 3 virus. Can.
J. Vet. Res. 1994;58(2): 148–51.
- Burton JL, Nonnecke BJ, Dubeski PL, Elsasser
TH, Mallard BA. Effects of supplemental
chromium on production of cytokines by
mitogen-stimulated bovine peripheral blood
mononuclear cells. J. Dairy Sci. 1996;79(12):
2237–46.
- Burton JL, Nonnecke BJ, Elsasser TH, Mallard
BA, Yang WZ, Mowat DN.
Immunomodulatory activity of blood serum
from chromium-supplemented periparturient
dairy cows. Vet. Immunol. Immunopathol.
1995;49: 29–38.
- Chang X, Mallard BA, Mowat DN. Proliferation
of peripheral blood lymphocytes of feeder
calves in response to chromium. Nutr. Res.
1994;14(6): 851–64.
- Chang X, Mallard BA, Mowat DN. Effects of
chromium on health status, blood neutrophil
phagocytosis and in vitro lymphocyte
blastogenesis of dairy cows. Vet. Immunol.
Immunopathol. 1996;52(1–2): 37–52.
- Chang X, Mowat DN. Supplemental chromium for
stressed and growing feeder calves. J. Anim.
Sci. 1992;70(2): 559–65.
- Chang X, Mowat DN, Mallard BA. Supplemental
Chromium and Niacin for Stressed Feeder
Calves. Can. J. Anim. Sci. 1995;75(3): 351–8.
- Faldyna M, Pechova A, Krejci J. Chromium
supplementation enhances antibody response
to vaccination with tetanus toxoid in cattle. J.
Vet. Med. Ser. B Infect. Dis. Vet. Public Heal.
2003;50(7): 326–31.
- Gatta PP, Thompson KD, Smullen R, Piva A,
Testi S, Adams A. Dietary organic chromium
supplementation and its effect on the immune
response of rainbow trout (Oncorhynchus
mykiss). Fish Shellfish Immunol. 2001;11(5):
371–82.
- Guidry AJ, Paape MJ, Pearson RE. Effects of
parturition and lactation on blood and milk
cell concentrations, corticosteroids, and
neutrophil phagocytosis in the cow. Am. J.
Vet. Res. 1976;37(10): 1195–200.
- Haq Z, Jain RK, Khan N, Dar MY, Ali S, Gupta
M, Varun TK. Recent advances in role of
chromium and its antioxidant combinations in
poultry nutrition: A review. Vet. World.
2016;9(12): 1392–9.
- Hayirli A, Bremmer DR, Bertics SJ, Socha MT,
Grummer RR. Effect of Chromium
Supplementation on Production and
Metabolic Parameters in Periparturient Dairy
Cows. J. Dairy Sci. 2001;84(5): 1218–30.
- Jain SK, Kannan K. Chromium chloride inhibits
oxidative stress and TNF-alpha secretion
caused by exposure to high glucose in
cultured U937 monocytes. Biochem. Biophys.
Res. Commun. 2001;289(3): 687–91.
- Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg
GR, Bruce-Robertson A. Chromium
deficiency, glucose intolerance, and
neuropathy reversed by chromium
supplementation, in a patient receiving longterm
total parenteral nutrition. Am. J. Clin.
Nutr. 1977;30(4): 531–8.
- Kafilzadeh F, shabankareh HK, Targhibi MR.
Effect of Chromium Supplementation on
Productive and Reproductive Performances
and Some Metabolic Parameters in Late
Gestation and Early Lactation of Dairy Cows.
Biol. Trace Elem. Res. 2012;149(1): 42–9.
- Kegley EB, Spears JW, Brown TT. Immune
Response and Disease Resistance of Calves
Fed Chromium Nicotinic Acid Complex or
Chromium Chloride. J. Dairy Sci. 1996;79(7):
1278–83.
- Kegley EB, Spears JW, Eisemann JH.
Performance and glucose metabolism in
calves fed a chromium-nicotinic acid complex
or chromium chloride. J. Dairy Sci.
1997;80(8): 1744–50.
- Kehrli ME, Nonnecke BJ, Roth JA. Alterations in
bovine neutrophil function during the
periparturient period. Am. J. Vet. Res.
1989a;50(2): 207–14.
- Kehrli ME, Nonnecke BJ, Roth JA. Alterations in
bovine lymphocyte function during the
periparturient period. Am. J. Vet. Res.
1989b;50(2): 215–20.
- Lee DN, Yen HT, Shen TF, Chen BJ.
Chromium-induced glucose uptake,
superoxide anion production, and
phagocytosis in cultured pulmonary alveolar
macrophages of weanling pigs. Biol. Trace
Elem. Res. 2000;77(1): 53–64.
- Lien TF, Yang KH, Lin KJ. Effects of chromium
propionate supplementation on growth
performance, serum traits and immune
response in weaned pigs. Asian-Australasian J.
Anim. Sci. 2005;18(3): 403–8.
- Lindell SA, Brandt, Robert T. J, Minton JE,
Blecha F, Stokka GL, Milton CT.
Supplemental chromium and revaccination
effects on performance and health of newly
weaned calves. Cattlemen’s Day. Kansas:
Kansas State University. Agricultural
Experiment Station and Cooperative
Extension Service; 1994. p. 32–5.
- Mallard B, Mowat D, Leslie K, Chang X, Wright
A. Immunomodulatory effects of chelated
chromium on dairy health and production.
Annu. Meet. Natl. Mastit. Counc. Virginia;
1994. p. 69–76.
- Mathisonl GW, Engstrom DF. Chromium and
protein supplements for growing-finishing
beef steers fed barley-based diets. Can. J.
Anim. 1995; 549–58.
- McNamara JP, Valdez F. Adipose Tissue
Metabolism and Production Responses to
Calcium Propionate and Chromium
Propionate. J. Dairy Sci. 2005;88(7): 2498–
507.
- Mertz W. Chromium. History and nutritional
importance. Biol. Trace Elem. Res.
1992;32(2): 3–8.
- Moonsie-Shageer S, Mowat DN. Effect of level of
supplemental chromium on performance,
serum constituents, and immune status of
stressed feeder calves. J. Anim. Sci.
1993;71(1): 232–8.
- Mowat DN, Chang X, Yang WZ. Chelated
chromium for stressed feeder calves. Can. J.
Anim. Sci. 1993;73: 49–55.
- Munck A, Guyre PM, Holbrook NJ. Physiological
functions of glucocorticoids in stress and their
relations to pharmacological actions. Endocr
Rev. 1984;5(1): 25–44.
- Myers MJ, Farrell DE, Evock-Clover CM, Cope
C V, Henderson M, Steele NC. Effect of
recombinant growth hormone and chromium
picolinate on cytokine production and growth
performance in swine. Pathobiology.
1995;63(5): 283–7.
- Pechova A, Pavlata L. Chromium as an essential
nutrient: a review. Vet. Med. (Praha).
2007;52(1): 1–18.
- Rabinowitz MB, Gonick HC, Levin SR,
Davidson MB. Clinical trial of chromium and
yeast supplements on carbohydrate and lipid
metabolism in diabetic men. Biol. Trace Elem.
Res. 1983;5(6): 449–66.
- Roth JA, Kaeberle ML. Effect of glucocorticoids
on the bovine immune system. J. Am. Vet.
Med. Assoc. 1982;180: 894–901.
- Schrauzer GN, Shrestha KP, Molenaar TB,
Mead S. Effects of chromium
supplementation on food energy utilization
and the trace-element composition in the liver
and heart of glucose-exposed young mice.
Biol. Trace Elem. Res. 1986;9(2): 79–87.
- Schwarz K, Mertz W. Chromium(III) and the
glucose tolerance factor. Arch. Biochem.
Biophys. 1959;85: 292–5.
- Shrivastava R, Upreti RK, Seth PK, Chaturvedi
UC. Effects of chromium on the immune
system. FEMS Immunol. Med. Microbiol.
2002. p. 1–7.
- Spears JW. Micronutrients and immune function in
cattle. Proc. Nutr. Soc. 2000. p. 587–94.
- Spears JW, Whisnant CS, Huntington GB, Lloyd
KE, Fry RS, Krafka K, Lamptey A, Hyda J.
Chromium propionate enhances insulin
sensitivity in growing cattle. J. Dairy Sci.
2012;95(4): 2037–45.
- Subiyatno A, Mowat DN, Yang WZ. Metabolite
and Hormonal Responses to Glucose or
Propionate Infusions in Periparturient Dairy
Cows Supplemented with Chromium. J. Dairy
Sci. 1996;79(8): 1436–45.
- van de Ligt JLG, Lindemann MD, Harmon RJ,
Monegue HJ, Cromwell GL. Effect of
chromium tripicolinate supplementation on
porcine immune response during the postweaning period. J. Anim. Sci. 2002;80(2):
449–55.
- Villalobos-F. JA, Romero-R. C, Tarragó-C. MR,
Rosado A. Supplementation with chromium
picolinate reduces the incidence of placental
retention in dairy cows. Can. J. Anim. Sci.
NRC Research Press Ottawa, Canada;
1997;77(2): 329–30.
- Xu X, Liu L, Long S-F, Piao X-S, Ward TL, Ji F.
Effects of Chromium Methionine
Supplementation with Different Sources of
Zinc on Growth Performance, Carcass Traits,
Meat Quality, Serum Metabolites, Endocrine
Parameters, and the Antioxidant Status in
Growing-Finishing Pigs. Biol. Trace Elem.
Res. 2017;162(1–3): 134–41.
Krom ile Beslemenin Bağışıklık Sistemi Üzerine Etkileri
Year 2017,
Volume: 10 Issue: 2, 99 - 105, 01.03.2017
Eyüp Eren Gültepe
,
Cangir Uyarlar
İsmail Bayram
Abstract
Krom (Cr) beslemesi üzerine birçok çalışma yapılmıştır. İlk dönemlerde araştırmacılar tarafından esansiyel bir besin maddesi/mineral olarak kabul edilmiş ve karbonhidrat metabolizması ile yakın ilişkisi detaylı biçimde ortaya konmuştur. Erken dönemde Cr mineralinin bağışıklık sistemi üzerine bazı etkileri olduğu in vitro çalışmalar ile keşfedilmiştir. Son yıllarda ise bu etkilerinin çiftlik bazındaki yansımaları ortaya konmaktadır. Bu çalışmada, Cr beslemesinin bağışıklık sistemi ve yanıtına etkileri incelenmiştir.
References
- Abraham AS, Sonnenblick M, Eini M. The effect
of chromium on cholesterol-induced
atherosclerosis in rabbits. Atherosclerosis.
1982a;41(2–3): 371–9.
- Abraham AS, Sonnenblick M, Eini M. The action
of chromium on serum lipids and on
atherosclerosis in cholesterol-fed rabbits.
Atherosclerosis. 1982b;42(2–3): 185–95.
- Anderson RA, Bryden NA, Polansky MM,
Deuster PA. Exercise effects on chromium
excretion of trained and untrained men
consuming a constant diet. J. Appl. Physiol.
1988;64(1): 249–52.
- Anderson RA, Polansky MM, Bryden NA,
Roginski EE, Patterson KY, Reamer DC.
Effect of Exercise (Running) on Serum
Glucose, Insulin, Glucagon, and Chromium
Excretion. Diabetes. 1982;31(3): 212–6.
- Arthington JD, Corah LR, Minton JE, Elsasser
TH, Blecha F. Supplemental Dietary
Chromium Does Not Influence ACTH,
Cortisol, or Immune Responses in Young
Calves Inoculated with Bovine Herpesvirus-1.
J. Anim. Sci. 1997;75(1): 217–23.
- Burton JL, Mallard BA, Mowat DN. Effects of
supplemental chromium on immune
responses of periparturient and early lactation
dairy cows. J. Anim. Sci. 1993;71(6): 1532–9.
- Burton JL, Mallard BA, Mowat DN. Effects of
supplemental chromium on antibody
responses of newly weaned feedlot calves to
immunization with infectious bovine
rhinotracheitis and parainfluenza 3 virus. Can.
J. Vet. Res. 1994;58(2): 148–51.
- Burton JL, Nonnecke BJ, Dubeski PL, Elsasser
TH, Mallard BA. Effects of supplemental
chromium on production of cytokines by
mitogen-stimulated bovine peripheral blood
mononuclear cells. J. Dairy Sci. 1996;79(12):
2237–46.
- Burton JL, Nonnecke BJ, Elsasser TH, Mallard
BA, Yang WZ, Mowat DN.
Immunomodulatory activity of blood serum
from chromium-supplemented periparturient
dairy cows. Vet. Immunol. Immunopathol.
1995;49: 29–38.
- Chang X, Mallard BA, Mowat DN. Proliferation
of peripheral blood lymphocytes of feeder
calves in response to chromium. Nutr. Res.
1994;14(6): 851–64.
- Chang X, Mallard BA, Mowat DN. Effects of
chromium on health status, blood neutrophil
phagocytosis and in vitro lymphocyte
blastogenesis of dairy cows. Vet. Immunol.
Immunopathol. 1996;52(1–2): 37–52.
- Chang X, Mowat DN. Supplemental chromium for
stressed and growing feeder calves. J. Anim.
Sci. 1992;70(2): 559–65.
- Chang X, Mowat DN, Mallard BA. Supplemental
Chromium and Niacin for Stressed Feeder
Calves. Can. J. Anim. Sci. 1995;75(3): 351–8.
- Faldyna M, Pechova A, Krejci J. Chromium
supplementation enhances antibody response
to vaccination with tetanus toxoid in cattle. J.
Vet. Med. Ser. B Infect. Dis. Vet. Public Heal.
2003;50(7): 326–31.
- Gatta PP, Thompson KD, Smullen R, Piva A,
Testi S, Adams A. Dietary organic chromium
supplementation and its effect on the immune
response of rainbow trout (Oncorhynchus
mykiss). Fish Shellfish Immunol. 2001;11(5):
371–82.
- Guidry AJ, Paape MJ, Pearson RE. Effects of
parturition and lactation on blood and milk
cell concentrations, corticosteroids, and
neutrophil phagocytosis in the cow. Am. J.
Vet. Res. 1976;37(10): 1195–200.
- Haq Z, Jain RK, Khan N, Dar MY, Ali S, Gupta
M, Varun TK. Recent advances in role of
chromium and its antioxidant combinations in
poultry nutrition: A review. Vet. World.
2016;9(12): 1392–9.
- Hayirli A, Bremmer DR, Bertics SJ, Socha MT,
Grummer RR. Effect of Chromium
Supplementation on Production and
Metabolic Parameters in Periparturient Dairy
Cows. J. Dairy Sci. 2001;84(5): 1218–30.
- Jain SK, Kannan K. Chromium chloride inhibits
oxidative stress and TNF-alpha secretion
caused by exposure to high glucose in
cultured U937 monocytes. Biochem. Biophys.
Res. Commun. 2001;289(3): 687–91.
- Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg
GR, Bruce-Robertson A. Chromium
deficiency, glucose intolerance, and
neuropathy reversed by chromium
supplementation, in a patient receiving longterm
total parenteral nutrition. Am. J. Clin.
Nutr. 1977;30(4): 531–8.
- Kafilzadeh F, shabankareh HK, Targhibi MR.
Effect of Chromium Supplementation on
Productive and Reproductive Performances
and Some Metabolic Parameters in Late
Gestation and Early Lactation of Dairy Cows.
Biol. Trace Elem. Res. 2012;149(1): 42–9.
- Kegley EB, Spears JW, Brown TT. Immune
Response and Disease Resistance of Calves
Fed Chromium Nicotinic Acid Complex or
Chromium Chloride. J. Dairy Sci. 1996;79(7):
1278–83.
- Kegley EB, Spears JW, Eisemann JH.
Performance and glucose metabolism in
calves fed a chromium-nicotinic acid complex
or chromium chloride. J. Dairy Sci.
1997;80(8): 1744–50.
- Kehrli ME, Nonnecke BJ, Roth JA. Alterations in
bovine neutrophil function during the
periparturient period. Am. J. Vet. Res.
1989a;50(2): 207–14.
- Kehrli ME, Nonnecke BJ, Roth JA. Alterations in
bovine lymphocyte function during the
periparturient period. Am. J. Vet. Res.
1989b;50(2): 215–20.
- Lee DN, Yen HT, Shen TF, Chen BJ.
Chromium-induced glucose uptake,
superoxide anion production, and
phagocytosis in cultured pulmonary alveolar
macrophages of weanling pigs. Biol. Trace
Elem. Res. 2000;77(1): 53–64.
- Lien TF, Yang KH, Lin KJ. Effects of chromium
propionate supplementation on growth
performance, serum traits and immune
response in weaned pigs. Asian-Australasian J.
Anim. Sci. 2005;18(3): 403–8.
- Lindell SA, Brandt, Robert T. J, Minton JE,
Blecha F, Stokka GL, Milton CT.
Supplemental chromium and revaccination
effects on performance and health of newly
weaned calves. Cattlemen’s Day. Kansas:
Kansas State University. Agricultural
Experiment Station and Cooperative
Extension Service; 1994. p. 32–5.
- Mallard B, Mowat D, Leslie K, Chang X, Wright
A. Immunomodulatory effects of chelated
chromium on dairy health and production.
Annu. Meet. Natl. Mastit. Counc. Virginia;
1994. p. 69–76.
- Mathisonl GW, Engstrom DF. Chromium and
protein supplements for growing-finishing
beef steers fed barley-based diets. Can. J.
Anim. 1995; 549–58.
- McNamara JP, Valdez F. Adipose Tissue
Metabolism and Production Responses to
Calcium Propionate and Chromium
Propionate. J. Dairy Sci. 2005;88(7): 2498–
507.
- Mertz W. Chromium. History and nutritional
importance. Biol. Trace Elem. Res.
1992;32(2): 3–8.
- Moonsie-Shageer S, Mowat DN. Effect of level of
supplemental chromium on performance,
serum constituents, and immune status of
stressed feeder calves. J. Anim. Sci.
1993;71(1): 232–8.
- Mowat DN, Chang X, Yang WZ. Chelated
chromium for stressed feeder calves. Can. J.
Anim. Sci. 1993;73: 49–55.
- Munck A, Guyre PM, Holbrook NJ. Physiological
functions of glucocorticoids in stress and their
relations to pharmacological actions. Endocr
Rev. 1984;5(1): 25–44.
- Myers MJ, Farrell DE, Evock-Clover CM, Cope
C V, Henderson M, Steele NC. Effect of
recombinant growth hormone and chromium
picolinate on cytokine production and growth
performance in swine. Pathobiology.
1995;63(5): 283–7.
- Pechova A, Pavlata L. Chromium as an essential
nutrient: a review. Vet. Med. (Praha).
2007;52(1): 1–18.
- Rabinowitz MB, Gonick HC, Levin SR,
Davidson MB. Clinical trial of chromium and
yeast supplements on carbohydrate and lipid
metabolism in diabetic men. Biol. Trace Elem.
Res. 1983;5(6): 449–66.
- Roth JA, Kaeberle ML. Effect of glucocorticoids
on the bovine immune system. J. Am. Vet.
Med. Assoc. 1982;180: 894–901.
- Schrauzer GN, Shrestha KP, Molenaar TB,
Mead S. Effects of chromium
supplementation on food energy utilization
and the trace-element composition in the liver
and heart of glucose-exposed young mice.
Biol. Trace Elem. Res. 1986;9(2): 79–87.
- Schwarz K, Mertz W. Chromium(III) and the
glucose tolerance factor. Arch. Biochem.
Biophys. 1959;85: 292–5.
- Shrivastava R, Upreti RK, Seth PK, Chaturvedi
UC. Effects of chromium on the immune
system. FEMS Immunol. Med. Microbiol.
2002. p. 1–7.
- Spears JW. Micronutrients and immune function in
cattle. Proc. Nutr. Soc. 2000. p. 587–94.
- Spears JW, Whisnant CS, Huntington GB, Lloyd
KE, Fry RS, Krafka K, Lamptey A, Hyda J.
Chromium propionate enhances insulin
sensitivity in growing cattle. J. Dairy Sci.
2012;95(4): 2037–45.
- Subiyatno A, Mowat DN, Yang WZ. Metabolite
and Hormonal Responses to Glucose or
Propionate Infusions in Periparturient Dairy
Cows Supplemented with Chromium. J. Dairy
Sci. 1996;79(8): 1436–45.
- van de Ligt JLG, Lindemann MD, Harmon RJ,
Monegue HJ, Cromwell GL. Effect of
chromium tripicolinate supplementation on
porcine immune response during the postweaning period. J. Anim. Sci. 2002;80(2):
449–55.
- Villalobos-F. JA, Romero-R. C, Tarragó-C. MR,
Rosado A. Supplementation with chromium
picolinate reduces the incidence of placental
retention in dairy cows. Can. J. Anim. Sci.
NRC Research Press Ottawa, Canada;
1997;77(2): 329–30.
- Xu X, Liu L, Long S-F, Piao X-S, Ward TL, Ji F.
Effects of Chromium Methionine
Supplementation with Different Sources of
Zinc on Growth Performance, Carcass Traits,
Meat Quality, Serum Metabolites, Endocrine
Parameters, and the Antioxidant Status in
Growing-Finishing Pigs. Biol. Trace Elem.
Res. 2017;162(1–3): 134–41.