Pandemi Sürecinde İnsidental Olarak Saptanan Pulmoner Aspergilloz Olgularının Radyolojik ve Patolojik Korelasyonu

Year 2024, Volume: 16 Issue: 1, 1 - 6, 30.04.2024

Tuba Oğuzsoy , Saim Türkoğlu

Abstract

Amaç: Pulmoner Aspergillozis genellikle daha önceden oluşan akciğer kavitelerinde kolonizasyon sonucunda gelişir. Bu çalışmada, retrospektif olarak histopatolojik Aspergillozis tanısı mevcut olgularda Bilgisayarlı tomografi (BT) bulguları ile uyumunun değerlendirilmesi amaçlanmıştır.
Materyal ve Metod: 2020 ve 2023 yılları arasında SBÜ Van Eğitim ve Araştırma Hastanesine histopatolojik olarak Aspergillozis tanısı mevcut 17 olguda BT görüntülemeleri incelenmiştir.
Bulgular: Tüm olgular kliniğe nefes darlığı, öksürük gibi Kovid-19 şüphesi ile başvurmuştur. Histomorfolojik olarak Hematoksilen ve Eosin boyalarında ve PAS ve Giemsa boyaları ile mantar hif ve spor yapıları tespit edilmiştir. En sık yerleşim üst lob olup, görüntülemelerde en sık bulgu kaviter ve nodüler lezyonlardır.
Sonuç: Sonuç olarak Aspergillozis tanısında ve tedavide BT görüntüleme invaziv olmayan kolay ve güvenilir bir yöntem olarak değerlendirilmiştir.

Keywords

Aspergillus, Bilgisayarlı Tomografi, Histopatoloji, Kaviter, Konsolüdasyon, Pulmoner

Radiological and Pathological Correlation of Pulmonary Aspergillosis Cases During The Pandemic

Abstract

Objective: Pulmonary Aspergillosis usually develops as a result of colonization in previously formed lung cavities. In this study, it was aimed to evaluate the compatibility with Computed tomography (CT) findings in cases with a retrospective histopathological diagnosis of Aspergillosis.
Materials and Methods: CT scans of 17 patients with histopathological diagnosis of Aspergillosis at SBU Van Training and Research Hospital between 2020 and 2023 were examined.
Results: All cases applied to the clinic with the suspicion of Covid-19 such as shortness of breath and cough. Histomorphologically, fungal hyphae and spore structures were detected in Hematoxylin and Eosin stains and with PAS and Giemsa stains. The most common location is the upper lobe, and the most common findings on imaging are cavitary and nodular lesions.
Conclusion: In conclusion, CT imaging has been evaluated as a non-invasive, easy and reliable method in the diagnosis and treatment of Aspergillosis.

Keywords

Aspergillus, Computed Tomography, Histopathology, Cavity, Consolidation, Pulmonary

References

• 1. Sakarya ME, Özbay B, Yalçınkaya İ, Arslan H, Uzun K, Poyraz N. Aspergillomas in the lung cavities. Eastern Journal of Medicine. 1998;3(1):7-9.
• 2. Panse P, Smith M, Cummings K, Jensen E, Gotway M, Jokerst C. The many faces of pulmonary aspergillosis: Imaging findings with pathologic correlation. Radiology of Infectious Diseases. 2016;3:192-200.
• 3. PD Barnes, KA Marr. Aspergillosis: spectrum of disease, diagnosis, and treatment. Infect Dis Clin North Am.2006;20:545-61.
• 4. Aquino SL, Kee ST, Warnock ML, Gamsu G. Pulmonary aspergillosis: imaging findings with pathologic correlation. American Journal of Roentgenology. 1994;163:4.
• 5. Sharma A, Ghosh S, Parnita. Ayushman. Imaging Studies with pathologic correlations showing the numerous different manifestations of pulmonary aspergillosis. Journal of Survey in Fisheries Sciences. 2023;10:1233-8.
• 6. Hoenigl M. Invasive Fungal Disease Complicating Coronavirus Disease 2019: When It Rains, It Spores. Clin Infect Dis. 2021;73:1645-8.
• 7. Baddley JW, Thompson GR, Chen SC, White PL, Johnson MD, Nguyen MH, et al. Coronavirus Disease 2019-Associated Invasive Fungal Infection. Open Forum Infect Dis. 2021;8:510.
• 8. Lai CC, Yu WL. COVID-19 associated with pulmonary aspergillosis: A literatüre review. J Microbiol Immunol Infect. 2021;54(1):46-53.
• 9. Gioia F, Walti NL, Cheff AO, Husain S. Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis. The Lancet Respiratory Medicine. 2024;12(3):207-16.
• 10. Collins J, Stern EJ. Chestradiology: The Essentials. Lippincott Williams &Wilkins. 2007
• 11. Parker MS, Christenson ML, Abbott GF. Teaching atlas of chest imaging. Thieme Medical Pub. 2005. ISBN:1588902307.
• 12. Franquet T, Müller NL, Giménez A, Guembe P, La Torre J, Bagué S. Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 2001;21(4):825-37.