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Year 2022, , 211 - 218, 30.05.2022

Emrah Keskın Ozlem Elmas Havva Hande Keser Sahın Caghan Tonge Ahmet Gunaydın

https://doi.org/10.5472/marumj.1121375
Cited By: 1

Abstract

References

  • [1] Allen C, Her S, Jaffray DA. Radiotherapy for Cancer: Present and Future. Adv Drug Deliv Rev 2017; 109:1-2. doi: 10.1016/j. addr.2017.01.004
  • [2] Citrin DE. Recent developments in radiotherapy. N Engl J Med 2017; 377:1065-75. doi: 10.1056/NEJMra1608986
  • [3] Li Z, Wang D, Zhang Y, Wang S, Wang X, Li Y, et al. The efficacy and safety of Xuebijing injection in the treatment of radiation pneumonitis: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2021; 100:e24344. doi: 10.1097/MD.000.000.0000024344
  • [4] Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, et al. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 2010; 76:94-100. doi: 10.1016/j.ijrobp.2009.06.092
  • [5] Aktas S, Comelekoglu U, Yilmaz SN, et al. Electrophysiological, biochemical and ultrastructural effects of radiotherapy on normal rat sciatic nerve. Int J Radiat Biol 2013; 89:155-61. doi: 10.3109/09553.002.2013.734941
  • [6] Santos MLC, de Brito BB, da Silva FAF, Botelho A, de Melo FF. Nephrotoxicity in cancer treatment: An overview. World J Clin Oncol 2020; 11:190-204. doi: 10.5306/wjco.v11.i4.190
  • [7] Eblan MJ, Corradetti MN, Lukens JN, et al. Brachial plexopathy in apical non-small cell lung cancer treated with definitive radiation: dosimetric analysis and clinical implications. Int J Radiat Oncol Biol Phys 2013; 85:175-81. doi: 10.1016/j. ijrobp.2012.03.051
  • [8] McNeish BL, Zheutlin AR, Richardson JK, Smith SR. Primary cancer location predicts predominant level of brachial plexopathy. Muscle Nerve 2020; 62:386-9. doi: 10.1002/ mus.26994
  • [9] He B, Wang X, He Y, Li H, Yang Y, Shi Z, et al. Gamma rayinduced glial activation and neuronal loss occur before the delayed onset of brain necrosis. FASEB J 2020; 34:13361-75. doi: 10.1096/fj.202000365RR
  • [10] Shabeeb D, Musa AE, Keshavarz M, et al. Histopathological and functional evaluation of radiation-induced sciatic nerve damage: Melatonin as radioprotector. Medicina (Kaunas) 2019; 55:502. doi: 10.3390/medicina55080502
  • [11] Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett 2012; 327:48-60. doi: 10.1016/j.canlet.2011.12.012
  • [12] Helm JS, Rudel RA. Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast. Arch Toxicol 2020; 94:1511-49. doi: 10.1007/s00204.020.02752-z
  • [13] Jacobo-Herrera NJ, Jacobo-Herrera FE, Zentella-Dehesa A, Andrade-Cetto A, Heinrich M, Perez-Plasencia C. Medicinal plants used in Mexican traditional medicine for the treatment of colorectal cancer. J Ethnopharmacol 2016; 179:391-402. doi: 10.1016/j.phymed.2020.153402
  • [14] Fischer N, Seo EJ, Efferth T. Prevention from radiation damage by natural products. Phytomedicine 2018; 47:192-200. doi: 10.1016/j.jep.2015.12.042
  • [15] Harvie M. Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book 2014: e478-86. doi: 10.1016/j.phymed.2017.11.005
  • [16] Liu YQ, Wang XL, He DH, Cheng YX. Protection against chemotherapy – and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine 2021; 80:153402. doi: 10.14694/edbook_am.2014.34.e478
  • [17] Moreau D, Huchot E, Gazaille V, Rossanaly-Vasram R, Andre M. Self medication with Annona muricata L. (corossol) as an anti-cancer agent in Reunion. Rev Mal Respir 2018; 35:948- 55. doi: 10.1016/j.rmr.2018.08.001
  • [18] Coria-Téllez AV, Montalvo-Gónzalez E, Yahia EM, Obledo- Vázquez EN. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arab J Chem 2018; 11:662-91. doi: 10.1016/j.arabjc.2016.01.004
  • [19] Balderrama-Carmona AP, Silva-Beltran NP, Galvez-Ruiz JC, Ruiz-Cruz S, Chaidez-Quiroz C, Moran-Palacio EF. Antiviral, antioxidant, and antihemolytic effect of Annona muricata L. leaves extracts. Plants (Basel) 2020; 9:1650. doi: 10.3390/ plants9121650
  • [20] Kim WS, Kim YE, Cho EJ, et al. Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide. Biosci Biotechnol Biochem 2020; 84:1001-12. doi: 10.1080/09168.451.2020.1715201
  • [21] Cattin AL, Lloyd AC. The multicellular complexity of peripheral nerve regeneration. Curr Opin Neurobiol 2016; 39:38-46. doi: 10.1016/j.conb.2016.04.005
  • [22] Lin Z, Wu VW, Ju W, Yamada Y, Chen L. Radiation-induced changes in peripheral nerve by stereotactic radiosurgery: a study on the sciatic nerve of rabbit. J Neurooncol 2011; 102:179-85. doi: 10.1007/s11060.010.0309-3
  • [23] Stubblefield MD. Clinical evaluation and management of radiation fibrosis syndrome. Phys Med Rehabil Clin N Am 2017; 28:89-100. doi: 10.1016/j.pmr.2016.08.003
  • [24] Love S, Gomez S. Effects of experimental radiation-induced hypomyelinating neuropathy on motor end-plates and neuromuscular transmission. J Neurol Sci 1984; 65:93-109. doi: 10.1016/0022-510X(84)90070-4
  • [25] Ge X, Liao Z, Yuan J, et al. Radiotherapy-related quality of life in patients with head and neck cancers: a meta-analysis. Support Care Cancer 2020; 28:2701-12. doi: 10.1007/ s00520.019.05077-5
  • [26] Egemen E, Öcal Ö, Börcek AÖ, et al. İyonize radyasyon sonrası gelişen oksidatif beyin ve spinal kord hasarını iyileştirmede deksametazon ve melatoninin etkilerinin sıçan modelinde karşılaştırılması. J Nerv Sys Surg 2021; 7:83-95. doi:10.54306/ SSCD.2021.18189
  • [27] Presman DM, Hoijman E, Ceballos NR, Galigniana MD, Pecci A. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Endocrinology 2006; 147: 5452-9. doi. org/10.1210/en.2006-0252
  • [28] Suzuki K. [Neurotoxicity of radiation]. Brain nerve 2015; 67:63-71. doi: 10.11477/mf.141.620.0087
  • [29] Okuhara Y, Shinomiya R, Peng F, et al. Direct effect of radiation on the peripheral nerve in a rat model. J Plast Surg Hand Surg 2014; 48:276-80. doi: 10.3109/2000656X.2014.882343
  • [30] El-Shahat AN. Ameliorative effect of graviola fruit juice on the damaged tissues of gamma-irradiated male rats. Pak J Zool 2021. doi: 10.17582/journal.pjz/202.011.13181133
  • [31] Moghadamtousi SZ, Rouhollahi E, Hajrezaie M, Karimian H, Abdulla MA, Kadir HA. Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence. Int J Surg 2015; 18:110-7. doi: 10.1016/j. ijsu.2015.03.026
  • [32] Keskin E, Elmas Ö, Keser Şahin HH, Güven B. Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis. Turkish Journal of Trauma and Emergency Surgery 2022; 28:233-41. doi: 10.14744/tjtes.2021.70728
  • [33] Heba H Mansour AAE, Amal H Elrefaei, Hafez F Hafez. Radioprotective, antioxidant and antitumor efficacy of Annona muricata L. leaf extract. Indian J Biochem Biophys 2018; 55:205-14.
  • [34] Kavita P, Jaimala S. Effect of Opuntia elatior on Alteration in Glutamic Oxaloacetic Transaminase activity induced by Gamma Radiation in Swiss Albino Mice. Int J Pharma Bio Sci 2020; 10:90-5. doi: 10.22376/ijpbs/lpr.2020.10.4.p90-95
  • [35] Najafi M, Motevaseli E, Shirazi A, Geraily G, Rezaeyan A, Norouzi F, et al. Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications. Int J Radiat Biol 2018; 94:335-56. doi: 10.1080/09553.002.2018.1440092.
  • [36] Vasko MR, Guo C, Thompson EL, Kelley MR. The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. DNA Repair 2011; 10:942-52. doi: 10.1016/j.dnarep.2011.06.004
  • [37] Hadj Abdallah N, Baulies A, Bouhlel A, et al. Zinc mitigates renal ischemia-reperfusion injury in rats by modulating oxidative stress, endoplasmic reticulum stress, and autophagy. J Cell Physiol 2018; 233:8677-90. doi: 10.1002/jcp.26747
  • [38] Tawfik SS, Elkady AA, El Khouly WA. Crocin mitigates gammarays- induced hepatic toxicity in rats. Environ Sci Pollut Res Int 2019; 26:15414-9. doi: 10.1007/s11356.019.04724-y
  • [39] Park S, Imlay JA. High levels of intracellular cysteine promote oxidative DNA damage by driving the fenton reaction. J Bacteriol 2003; 185:1942-50. doi: 10.1128/JB.185.6.1942- 1950.2003
  • [40] Wu Z, Wang H, Fang S, Xu C. Roles of endoplasmic reticulum stress and autophagy on H2O2induced oxidative stress injury in HepG2 cells. Mol Med Rep 2018; 18:4163-74. doi: 10.3892/ mmr.2018.9443
  • [41] Fujiki Y, Bassik MC. A New Paradigm in Catalase Research. Trends Cell Biol 2021; 31:148-51. doi: 10.1016/j. tcb.2020.12.006
  • [42] Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Abdulla MA, Kadir HA. Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement. Drug Des Devel Ther 2014; 8:2099-110. doi: 10.2147/DDDT.S70096

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

Year 2022, , 211 - 218, 30.05.2022

Emrah Keskın Ozlem Elmas Havva Hande Keser Sahın Caghan Tonge Ahmet Gunaydın

https://doi.org/10.5472/marumj.1121375
Cited By: 1

Abstract

Objective: This study aimed to evaluate Annona muricata’s (AM) radioprotective effects on sciatic nerve injury due to ionising
radiation (IR).

Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control (C), Annona
muricata leaf extracts (AME), radiation (RAD), radiation and AME (AME+RAD). In groups AME and AME+RAD, AME was
administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and
AME+RAD, rats were exposed to a single dose of 20 Gray (Gy) IR to their right legs. All the subjects were sacrificed at the end of
the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were
extracted and histomorphology was evaluated.

Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME
(p<0.01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase (p<0.01), superoxide
dismutase (p<0.01) and glutathione peroxidase (p<0.05) in the AME+RAD group compared to the RAD group were found to be
statistically significant.


Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period
on sciatic nerve injury due to IR.

Keywords

Radiation Sciatic nerve Annona muricata Neuroprotection Oxidative stress

References

  • [1] Allen C, Her S, Jaffray DA. Radiotherapy for Cancer: Present and Future. Adv Drug Deliv Rev 2017; 109:1-2. doi: 10.1016/j. addr.2017.01.004
  • [2] Citrin DE. Recent developments in radiotherapy. N Engl J Med 2017; 377:1065-75. doi: 10.1056/NEJMra1608986
  • [3] Li Z, Wang D, Zhang Y, Wang S, Wang X, Li Y, et al. The efficacy and safety of Xuebijing injection in the treatment of radiation pneumonitis: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2021; 100:e24344. doi: 10.1097/MD.000.000.0000024344
  • [4] Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, et al. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 2010; 76:94-100. doi: 10.1016/j.ijrobp.2009.06.092
  • [5] Aktas S, Comelekoglu U, Yilmaz SN, et al. Electrophysiological, biochemical and ultrastructural effects of radiotherapy on normal rat sciatic nerve. Int J Radiat Biol 2013; 89:155-61. doi: 10.3109/09553.002.2013.734941
  • [6] Santos MLC, de Brito BB, da Silva FAF, Botelho A, de Melo FF. Nephrotoxicity in cancer treatment: An overview. World J Clin Oncol 2020; 11:190-204. doi: 10.5306/wjco.v11.i4.190
  • [7] Eblan MJ, Corradetti MN, Lukens JN, et al. Brachial plexopathy in apical non-small cell lung cancer treated with definitive radiation: dosimetric analysis and clinical implications. Int J Radiat Oncol Biol Phys 2013; 85:175-81. doi: 10.1016/j. ijrobp.2012.03.051
  • [8] McNeish BL, Zheutlin AR, Richardson JK, Smith SR. Primary cancer location predicts predominant level of brachial plexopathy. Muscle Nerve 2020; 62:386-9. doi: 10.1002/ mus.26994
  • [9] He B, Wang X, He Y, Li H, Yang Y, Shi Z, et al. Gamma rayinduced glial activation and neuronal loss occur before the delayed onset of brain necrosis. FASEB J 2020; 34:13361-75. doi: 10.1096/fj.202000365RR
  • [10] Shabeeb D, Musa AE, Keshavarz M, et al. Histopathological and functional evaluation of radiation-induced sciatic nerve damage: Melatonin as radioprotector. Medicina (Kaunas) 2019; 55:502. doi: 10.3390/medicina55080502
  • [11] Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett 2012; 327:48-60. doi: 10.1016/j.canlet.2011.12.012
  • [12] Helm JS, Rudel RA. Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast. Arch Toxicol 2020; 94:1511-49. doi: 10.1007/s00204.020.02752-z
  • [13] Jacobo-Herrera NJ, Jacobo-Herrera FE, Zentella-Dehesa A, Andrade-Cetto A, Heinrich M, Perez-Plasencia C. Medicinal plants used in Mexican traditional medicine for the treatment of colorectal cancer. J Ethnopharmacol 2016; 179:391-402. doi: 10.1016/j.phymed.2020.153402
  • [14] Fischer N, Seo EJ, Efferth T. Prevention from radiation damage by natural products. Phytomedicine 2018; 47:192-200. doi: 10.1016/j.jep.2015.12.042
  • [15] Harvie M. Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book 2014: e478-86. doi: 10.1016/j.phymed.2017.11.005
  • [16] Liu YQ, Wang XL, He DH, Cheng YX. Protection against chemotherapy – and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine 2021; 80:153402. doi: 10.14694/edbook_am.2014.34.e478
  • [17] Moreau D, Huchot E, Gazaille V, Rossanaly-Vasram R, Andre M. Self medication with Annona muricata L. (corossol) as an anti-cancer agent in Reunion. Rev Mal Respir 2018; 35:948- 55. doi: 10.1016/j.rmr.2018.08.001
  • [18] Coria-Téllez AV, Montalvo-Gónzalez E, Yahia EM, Obledo- Vázquez EN. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arab J Chem 2018; 11:662-91. doi: 10.1016/j.arabjc.2016.01.004
  • [19] Balderrama-Carmona AP, Silva-Beltran NP, Galvez-Ruiz JC, Ruiz-Cruz S, Chaidez-Quiroz C, Moran-Palacio EF. Antiviral, antioxidant, and antihemolytic effect of Annona muricata L. leaves extracts. Plants (Basel) 2020; 9:1650. doi: 10.3390/ plants9121650
  • [20] Kim WS, Kim YE, Cho EJ, et al. Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide. Biosci Biotechnol Biochem 2020; 84:1001-12. doi: 10.1080/09168.451.2020.1715201
  • [21] Cattin AL, Lloyd AC. The multicellular complexity of peripheral nerve regeneration. Curr Opin Neurobiol 2016; 39:38-46. doi: 10.1016/j.conb.2016.04.005
  • [22] Lin Z, Wu VW, Ju W, Yamada Y, Chen L. Radiation-induced changes in peripheral nerve by stereotactic radiosurgery: a study on the sciatic nerve of rabbit. J Neurooncol 2011; 102:179-85. doi: 10.1007/s11060.010.0309-3
  • [23] Stubblefield MD. Clinical evaluation and management of radiation fibrosis syndrome. Phys Med Rehabil Clin N Am 2017; 28:89-100. doi: 10.1016/j.pmr.2016.08.003
  • [24] Love S, Gomez S. Effects of experimental radiation-induced hypomyelinating neuropathy on motor end-plates and neuromuscular transmission. J Neurol Sci 1984; 65:93-109. doi: 10.1016/0022-510X(84)90070-4
  • [25] Ge X, Liao Z, Yuan J, et al. Radiotherapy-related quality of life in patients with head and neck cancers: a meta-analysis. Support Care Cancer 2020; 28:2701-12. doi: 10.1007/ s00520.019.05077-5
  • [26] Egemen E, Öcal Ö, Börcek AÖ, et al. İyonize radyasyon sonrası gelişen oksidatif beyin ve spinal kord hasarını iyileştirmede deksametazon ve melatoninin etkilerinin sıçan modelinde karşılaştırılması. J Nerv Sys Surg 2021; 7:83-95. doi:10.54306/ SSCD.2021.18189
  • [27] Presman DM, Hoijman E, Ceballos NR, Galigniana MD, Pecci A. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Endocrinology 2006; 147: 5452-9. doi. org/10.1210/en.2006-0252
  • [28] Suzuki K. [Neurotoxicity of radiation]. Brain nerve 2015; 67:63-71. doi: 10.11477/mf.141.620.0087
  • [29] Okuhara Y, Shinomiya R, Peng F, et al. Direct effect of radiation on the peripheral nerve in a rat model. J Plast Surg Hand Surg 2014; 48:276-80. doi: 10.3109/2000656X.2014.882343
  • [30] El-Shahat AN. Ameliorative effect of graviola fruit juice on the damaged tissues of gamma-irradiated male rats. Pak J Zool 2021. doi: 10.17582/journal.pjz/202.011.13181133
  • [31] Moghadamtousi SZ, Rouhollahi E, Hajrezaie M, Karimian H, Abdulla MA, Kadir HA. Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence. Int J Surg 2015; 18:110-7. doi: 10.1016/j. ijsu.2015.03.026
  • [32] Keskin E, Elmas Ö, Keser Şahin HH, Güven B. Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis. Turkish Journal of Trauma and Emergency Surgery 2022; 28:233-41. doi: 10.14744/tjtes.2021.70728
  • [33] Heba H Mansour AAE, Amal H Elrefaei, Hafez F Hafez. Radioprotective, antioxidant and antitumor efficacy of Annona muricata L. leaf extract. Indian J Biochem Biophys 2018; 55:205-14.
  • [34] Kavita P, Jaimala S. Effect of Opuntia elatior on Alteration in Glutamic Oxaloacetic Transaminase activity induced by Gamma Radiation in Swiss Albino Mice. Int J Pharma Bio Sci 2020; 10:90-5. doi: 10.22376/ijpbs/lpr.2020.10.4.p90-95
  • [35] Najafi M, Motevaseli E, Shirazi A, Geraily G, Rezaeyan A, Norouzi F, et al. Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications. Int J Radiat Biol 2018; 94:335-56. doi: 10.1080/09553.002.2018.1440092.
  • [36] Vasko MR, Guo C, Thompson EL, Kelley MR. The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. DNA Repair 2011; 10:942-52. doi: 10.1016/j.dnarep.2011.06.004
  • [37] Hadj Abdallah N, Baulies A, Bouhlel A, et al. Zinc mitigates renal ischemia-reperfusion injury in rats by modulating oxidative stress, endoplasmic reticulum stress, and autophagy. J Cell Physiol 2018; 233:8677-90. doi: 10.1002/jcp.26747
  • [38] Tawfik SS, Elkady AA, El Khouly WA. Crocin mitigates gammarays- induced hepatic toxicity in rats. Environ Sci Pollut Res Int 2019; 26:15414-9. doi: 10.1007/s11356.019.04724-y
  • [39] Park S, Imlay JA. High levels of intracellular cysteine promote oxidative DNA damage by driving the fenton reaction. J Bacteriol 2003; 185:1942-50. doi: 10.1128/JB.185.6.1942- 1950.2003
  • [40] Wu Z, Wang H, Fang S, Xu C. Roles of endoplasmic reticulum stress and autophagy on H2O2induced oxidative stress injury in HepG2 cells. Mol Med Rep 2018; 18:4163-74. doi: 10.3892/ mmr.2018.9443
  • [41] Fujiki Y, Bassik MC. A New Paradigm in Catalase Research. Trends Cell Biol 2021; 31:148-51. doi: 10.1016/j. tcb.2020.12.006
  • [42] Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Abdulla MA, Kadir HA. Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement. Drug Des Devel Ther 2014; 8:2099-110. doi: 10.2147/DDDT.S70096
There are 42 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

Emrah Keskın This is me 0000-0001-5326-741X

Ozlem Elmas This is me 0000-0001-8039-9610

Havva Hande Keser Sahın This is me 0000-0003-1827-1039

Caghan Tonge This is me 0000-0002-9921-1750

Ahmet Gunaydın This is me 0000-0002-3292-5791

Publication Date May 30, 2022
Published in Issue Year 2022

Cite

APA Keskın, E., Elmas, O., Keser Sahın, H. H., Tonge, C., et al. (2022). The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury. Marmara Medical Journal, 35(2), 211-218. https://doi.org/10.5472/marumj.1121375
AMA Keskın E, Elmas O, Keser Sahın HH, Tonge C, Gunaydın A. The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury. Marmara Med J. May 2022;35(2):211-218. doi:10.5472/marumj.1121375
Chicago Keskın, Emrah, Ozlem Elmas, Havva Hande Keser Sahın, Caghan Tonge, and Ahmet Gunaydın. “The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury”. Marmara Medical Journal 35, no. 2 (May 2022): 211-18. https://doi.org/10.5472/marumj.1121375.
EndNote Keskın E, Elmas O, Keser Sahın HH, Tonge C, Gunaydın A (May 1, 2022) The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury. Marmara Medical Journal 35 2 211–218.
IEEE E. Keskın, O. Elmas, H. H. Keser Sahın, C. Tonge, and A. Gunaydın, “The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury”, Marmara Med J, vol. 35, no. 2, pp. 211–218, 2022, doi: 10.5472/marumj.1121375.
ISNAD Keskın, Emrah et al. “The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury”. Marmara Medical Journal 35/2 (May 2022), 211-218. https://doi.org/10.5472/marumj.1121375.
JAMA Keskın E, Elmas O, Keser Sahın HH, Tonge C, Gunaydın A. The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury. Marmara Med J. 2022;35:211–218.
MLA Keskın, Emrah et al. “The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury”. Marmara Medical Journal, vol. 35, no. 2, 2022, pp. 211-8, doi:10.5472/marumj.1121375.
Vancouver Keskın E, Elmas O, Keser Sahın HH, Tonge C, Gunaydın A. The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury. Marmara Med J. 2022;35(2):211-8.

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