Healing effects of L-carnitine on experimental colon anastomosis wound

Year 2023, , 215 - 222, 31.05.2023

Emel Kandas Mustafa Edremıtlıoglu Ufuk Demır Guven Erbıl Muserref Hilal Sehıtoglu

https://doi.org/10.5472/marumj.1307971

Abstract

Objective: The purpose of this study is to examine the effects of L-carnitine on healing of experimental colon anastomosis injury in
early and late period.
Materials and Methods: Forty female Wistar-Albino rats were used in this study. The rats were divided into 4 groups (CONT-3, CONT-
7, CARN-3, and CARN-7). Injury healing was evaluated for CONT-3 group on the 3rd day and for CONT-7 group on the 7th day
following the anastomosis. Following the operation, CARN-3 and CARN-7 groups were intraperitoneally administered with 100 mg/
kg/day L-carnitine and injury healing was evaluated on the 3rd and 7th days. Injury strength, histological evaluation and antioxidant
enzyme activities and oxidant damage were determined in tissue samples of anastomosis area.
Results: Bursting pressure levels and histological scoring values of CARN-3 group were found to be higher than the CONT-3 group
(p<0.05). Antioxidant enzyme activities were found to be high in groups which were administered with L-carnitine, and oxidant
damage was found to be significantly low in CARN-7 group (p<0.05).
Conclusion: It was seen that L-carnitine speeds up the injury healing process and increases the injury strength and antioxidant capacity
in early period. Increase in antioxidant enzyme activities was observed to be continued in late period as well.

Keywords

L-carnitine, Colon anastomosis, Antioxidant, Bursting pressure

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