Abstract
Peritoneal mesotheliomas are aggressive tumors arising from the
peritoneal mesothelium. Tumor markers are biochemical substances
produced by tumor cells due to the effect of malignant process.
They can be used for screening, diagnosis, and predicting the
prognosis. β-human chorionic β-human chorionic gonadotrophin
(β-hCG), is a marker of germ cell tumors and trophoblastic
diseases. In some reports, a relationship between β-hCG and
other malignant diseases has been described. Hereby, we present
a case of malignant peritoneal mesothelioma associated with
elevated serum β-hCG levels. A 49-year-old man was admitted to
the hospital with ascites. Peritoneal mesothelioma was diagnosed
with peritoneal biopsy. During the treatment period, serum β-hCG
levels were elevated together with disease progression and tissue
samples stained positive for β-hCG. Rising levels of serum β-hCG
due to disease progression can predict the response to treatment.
If these levels were elevated at the beginning of the treatment, it
may be a prognostic marker for peritoneal mesothelioma. Thus,
β-hCG may be an important marker for prognosis or prediction of
treatment for peritoneal mesothelioma patients.
References
- Raptopoulos V. Peritoneal mesothelioma. Crit Rev Diagn Imaging 1985;24:293-328.
- Selvam NT, Elumalai P, Venkatakrishnan V, Damodarkumar S. Molecular markers in cancer diagnosis and management: A Review. JAppl Biol Sci 2011;5: 69-74. doi: 10.1002/ iso.21787
- Hussa RO. The clinical marker hCG. New York: Praeger, 1987.doi: 10.1038/modpathol.3800086
- Berhil H, Chenna H, Nouni K, et al. Malignant mesothelioma of peritoneum: about a case with review of the literature. J Cancer Sci Ther 2012;4:235-6. doi:10.4172/19485956.1000147
- Rich S, Presant CA, Meyer J, Stevens SC, Carr D. Human chorionic gonadrotropin and malignant mesothelioma. Cancer 1979; 43: 1457-62.
- Okamoto H, Matsuno Y, Noguchi M, et al.Malignant pleural mesothelioma producing human chorionic gonadotropin. Am J Surg Pathol 1992;16:969-74.
- Zimmerman R L, Fogt F. The β subunit of human chorionic gonadotropin lacks specificity for malignant cells in serous effusions. Modern Pathology 2004;17:701-4. doi: 10.4172/1948-5956.1000147
- Ugurman F, Gozu A, Akkalyoncu B, et al. Pleural fluid and serum β-hcg levels and pleural fluıd/serum β-hcg ratio for the discrimination of malignant and benign pleural effusions. Solunum Hastalıkları 2003;14: 186-92.doi: 10.4103/09758844.106192
- Gibbs AR, Harach R, Wagner JC, Jasani B. Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. Thorax 1985; 40: 91-5.
- deBruijn HW, ten Hoor KA, Frans M, et al. Rising serum values of beta-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas. Br J Cancer 1997;75:1217-18.
Abstract
Peritoneal mezotelyomalar, peritoneal mezotelyumdan köken alan agresif tümörlerdir. Tümör belirteçleri, malign olayların etkilerinden dolayı üretilen biyokimyasal maddelerdir. Kanser taramasında, tanısında, ya da kanser prognozunu belirlemek için kullanılabilir. β-human koryonik gonadotropin (β-hCG), germ hücreli tümörler ve trofoblastik hastalıklarda kullanılan bir belirteçtir. Bazı yayınlarda yazarlar, β-hCG’nin diğer malignitelerle de ilişkili olabileceğini belirtmişlerdir. Biz burada, serum β-hCG yüksekliği ile seyreden malign peritoneal mezotelyomalı hastamızı sunduk. 49 yaşında bir erkek hasta hastaneye assitle başvurdu. Peritoneal mezotelyoma tanısı periton biyopsisiyle kondu. Tedavisi devam ettiği sırada hastalık progresyonuyla birlikte serum β-hCG seviyesi yükseldi ve doku β-hCG ile pozitif olarak boyandı. Hastalık progresyonuyla artan serum β-hCG seviyeleri tedavi yanıtını predikte edebilir. Eğer peritoneal mezotelyomalı bir hastada serum β-hCG seviyesi tedavi başlangıcında yüksek olarak saptandıysa, prognostik bir belirteç olarak kullanılabilir. Tüm bunlardan dolayı, β-hCG’nin peritoneal mezotelyomalı hastalarda tedaviyi predikte edebilecek ve prognozu belirlemede yardımcı önemli bir belirteç olarak kullanılabileceğini düşünüyoruz
References
- Raptopoulos V. Peritoneal mesothelioma. Crit Rev Diagn Imaging 1985;24:293-328.
- Selvam NT, Elumalai P, Venkatakrishnan V, Damodarkumar S. Molecular markers in cancer diagnosis and management: A Review. JAppl Biol Sci 2011;5: 69-74. doi: 10.1002/ iso.21787
- Hussa RO. The clinical marker hCG. New York: Praeger, 1987.doi: 10.1038/modpathol.3800086
- Berhil H, Chenna H, Nouni K, et al. Malignant mesothelioma of peritoneum: about a case with review of the literature. J Cancer Sci Ther 2012;4:235-6. doi:10.4172/19485956.1000147
- Rich S, Presant CA, Meyer J, Stevens SC, Carr D. Human chorionic gonadrotropin and malignant mesothelioma. Cancer 1979; 43: 1457-62.
- Okamoto H, Matsuno Y, Noguchi M, et al.Malignant pleural mesothelioma producing human chorionic gonadotropin. Am J Surg Pathol 1992;16:969-74.
- Zimmerman R L, Fogt F. The β subunit of human chorionic gonadotropin lacks specificity for malignant cells in serous effusions. Modern Pathology 2004;17:701-4. doi: 10.4172/1948-5956.1000147
- Ugurman F, Gozu A, Akkalyoncu B, et al. Pleural fluid and serum β-hcg levels and pleural fluıd/serum β-hcg ratio for the discrimination of malignant and benign pleural effusions. Solunum Hastalıkları 2003;14: 186-92.doi: 10.4103/09758844.106192
- Gibbs AR, Harach R, Wagner JC, Jasani B. Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. Thorax 1985; 40: 91-5.
- deBruijn HW, ten Hoor KA, Frans M, et al. Rising serum values of beta-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas. Br J Cancer 1997;75:1217-18.