Liver function tests in chronic viral hepatitis cases

Year 2016, , 6 - 9, 01.08.2016

Goncagül Haklar

https://doi.org/10.5472/MMJsi.2901.03

Cited By: 2

Abstract

The liver has many vital functions and biochemical tests are usedfor the assessment. For the diagnosis of chronic hepatitis: (1)persistence of increased alanine aminotransferase (ALT) for 6months after an episode of acute hepatitis; or (2) increased ALT(without another explanation) on more than one occasion over aperiod of 6 months are needed. The time period may be shorter forthe patients with risk factors. Although the clinical picture of HBVand HCV in chronic cases is similar, aminotransferase activitiesare different. In HBV, ALT activity is generally constant, exceptincreases are evident at seroconversion times. On the other hand,two-third of HCV cases experience fluctuation. In the evaluationof a patient with a new diagnosis of chronic viral hepatitis, acomprehensive medical history should be taken, followed byfull physical examination. Laboratory workup should start with acomprehensive metabolic panel with liver function tests includingassessment of synthetic function with prothrombin time and serumalbumin level measurement. Screening for the chronic hepaticinjury is not cost-effective and should be limited to high-riskindividuals. ALT should be the preferred biochemistry parameterbesides viral serology and increased activity should be confirmedbefore further evaluation. For treatment, patients with increasedALT are more likely to respond than those with initially normalALT activity.Keywords: Chronic viral hepatitis, Hepatitis B virus, Hepatitis Cvirus, Alanine aminotransferase, Aspartate aminotransferase

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