Case Report
BibTex RIS Cite

Yoğunluk ayarlı radyoterapi sonrasında gelişen carotid blowout sendromu: Olgu sunumu

Year 2017, , 124 - 129, 14.05.2017
https://doi.org/10.5472/marumj.344828

Abstract

Carotid blowout sendromu (CBS) veya pseudoaneurysm,

baş-boyun cerrahisi ve radyoterapi sonrası nadir görülen bir

komplikasyondur. Yüksek morbidite ve mortalite oranları ile masif

kulak kanaması veya epistaksis şeklinde görülür. Zayıflamış damar

yapısı ve masif kanama sebebiyle acil cerrahi ya da endovasküler

tedavilerin başarı şansı oldukça düşüktür. Bu yazıda, nazofarenks

kanseri tanısı olan ve eş zamanlı kemoterapi ile beraber yoğunluk

ayarlı radyoterapi (YART) C alan 3. evre (T3N2M0), 45 yaşında

erkek hasta sunulmuştur. Radyoterapi sonrası 8. ayda epistaksis

ile hastaneye başvuran hastanın sağ internal carotis arter

anjiografisinde petros segmentin antero-superior duvarında 4mm

pseudoanevrizma saptanıp aynı seansta stentle kanama kontrolu

yapılmıştır. Bu yazıda, erken tanı konulabilmesi ve dolayısıyla

daha az morbid tedavi seçeneklerinin sunulabilmesi için nadir

görülen bu klinik duruma dikkat çekilmesi amaçlanmıştır.

References

  • Chaloupka JC, Putman CM, Citardi MJ, et al. Endovascular therapy for the carotid blowout syndrome in head and neck surgical patients: Diagnostic and managerial considerations. AJNR Am J Neuroradiol 1996;17:843–52.
  • Powitzky R, Vasan N, Krempl G, Medina J. Carotid blowout in patients with head and neck cancer. Ann Otol Rhinol Laryngol 2010; 119: 476–84. doi: 10.1177/000348941011900709
  • Corre I, Niaudet C, Paris F. Plasma membrane signaling induced by ionizing radiation. Mutat Res 2010; 704, 61-7. doi: 10.1016/j.mrrev.2010.01.014
  • McDonald MW, Moore MG, Johnstone PA. Risk of carotid blowout after reirradiation of the head and neck: a systematic review. Int J Radiat Oncol Biol Phys 2012;82:1083-9.doi: 10.1016/j.ijrobp.2010.08.029
  • Lee N, Harris J, Garden AS, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009;27:3684-90. doi: 10.1200/JCO.2008.19.9109
  • Kwong DL, Sham JS, Leung LH, et al. Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2006;64:374-81. doi: http://dx.doi.org/10.1016/j.ijrobp.2005.07.968
  • Lin YW, Chen CC, Lin LC, Lee SP. The impact of reduced-volume, intensity-modulated radiation therapy on disease control in nasopharyngeal carcinoma. PLoS ONE. 2015;10:e0125283. doi: https://doi.org/10.1371/journal. pone.0125283
  • Mohan R, Wu Q, Manning M, Schmidt-Ullrich R. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 2000;46:619- 30.
  • Qiu S, Lin S, Tham IW, et al. Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngealcarcinoma. Int J Radiat Oncol Biol Phys 2012;83:676-83. doi: 10.1016/j.ijrobp.2011.07.006.
  • Chua DT, Sham JS, Kwong PW, et al. Linear acceleratorbased stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications. Int J Radiat Oncol Biol Phys 2003;56:177-83.
  • Lu TX, Mai WY, Teh BS, et al. Initial experience using intensitymodulated radiotherapy for recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2004;58:682-7. doi: 10.1016/S0360-3016(03)01508-6
  • Tian YM, Zhao C, Guo Y, et al. Effect of total dose and fraction size on survival of patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: A phase 2, single-center, randomized controlledtrial. Cancer 2014; 120:3502-9. doi: 10.1002/cncr.28934,
  • Yamazaki H, Ogita M, Kodani N, et al. Frequency, outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife: a multi-institutional study. Radiother Oncol 2013;107:305-9.
  • Yazici G, Sanlı T Y, Cengiz M, et al. A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers. Radiat Oncol 2013; 8: 242. doi: 10.1186/1748-717X-8-242
  • Cengiz M, Ozyigit G, Yazici G, et al. Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent headand- neck tumors. Int J Radiat Oncol Biol Phys 2011;81:104- 9. doi: 10.1016/j.ijrobp.2010.04.027

Carotid blowout syndrome after intensity-modulated radiation therapy: A case report

Year 2017, , 124 - 129, 14.05.2017
https://doi.org/10.5472/marumj.344828

Abstract

Carotid blowout syndrome (CBS) is a rarely seen complication of

head-neck surgery and radiation therapy. It may present by massive

ear bleeding or epistaxis with high morbidity and mortality rates.

Success rate of endovascular therapy or emergency surgery is

unfortunately low because of massive bleeding and weakened

vessel architecture. Here, we present a 45-year-old male with

nasopharyngeal carcinoma and treated with intensity-modulated

radiation therapy (IMRT) and concurrent chemotherapy. The

patient was diagnosed with stage III (T3N2M0) carcinoma of the

nasopharynx. Eight months after radiotherapy, he was admitted

to hospital with the complaint of epistaxis. Right internal carotid

angiography revealed a 4 mm pseudoaneurysm at the superioranterior

wall of the petrous and his bleeding was controlled by

stenting in the same session. In this report we aimed to draw

attention to this rare clinical situation that might enhance the chance

of early diagnosis enabling less morbid treatment opportunities.

References

  • Chaloupka JC, Putman CM, Citardi MJ, et al. Endovascular therapy for the carotid blowout syndrome in head and neck surgical patients: Diagnostic and managerial considerations. AJNR Am J Neuroradiol 1996;17:843–52.
  • Powitzky R, Vasan N, Krempl G, Medina J. Carotid blowout in patients with head and neck cancer. Ann Otol Rhinol Laryngol 2010; 119: 476–84. doi: 10.1177/000348941011900709
  • Corre I, Niaudet C, Paris F. Plasma membrane signaling induced by ionizing radiation. Mutat Res 2010; 704, 61-7. doi: 10.1016/j.mrrev.2010.01.014
  • McDonald MW, Moore MG, Johnstone PA. Risk of carotid blowout after reirradiation of the head and neck: a systematic review. Int J Radiat Oncol Biol Phys 2012;82:1083-9.doi: 10.1016/j.ijrobp.2010.08.029
  • Lee N, Harris J, Garden AS, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009;27:3684-90. doi: 10.1200/JCO.2008.19.9109
  • Kwong DL, Sham JS, Leung LH, et al. Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2006;64:374-81. doi: http://dx.doi.org/10.1016/j.ijrobp.2005.07.968
  • Lin YW, Chen CC, Lin LC, Lee SP. The impact of reduced-volume, intensity-modulated radiation therapy on disease control in nasopharyngeal carcinoma. PLoS ONE. 2015;10:e0125283. doi: https://doi.org/10.1371/journal. pone.0125283
  • Mohan R, Wu Q, Manning M, Schmidt-Ullrich R. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 2000;46:619- 30.
  • Qiu S, Lin S, Tham IW, et al. Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngealcarcinoma. Int J Radiat Oncol Biol Phys 2012;83:676-83. doi: 10.1016/j.ijrobp.2011.07.006.
  • Chua DT, Sham JS, Kwong PW, et al. Linear acceleratorbased stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications. Int J Radiat Oncol Biol Phys 2003;56:177-83.
  • Lu TX, Mai WY, Teh BS, et al. Initial experience using intensitymodulated radiotherapy for recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2004;58:682-7. doi: 10.1016/S0360-3016(03)01508-6
  • Tian YM, Zhao C, Guo Y, et al. Effect of total dose and fraction size on survival of patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: A phase 2, single-center, randomized controlledtrial. Cancer 2014; 120:3502-9. doi: 10.1002/cncr.28934,
  • Yamazaki H, Ogita M, Kodani N, et al. Frequency, outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife: a multi-institutional study. Radiother Oncol 2013;107:305-9.
  • Yazici G, Sanlı T Y, Cengiz M, et al. A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers. Radiat Oncol 2013; 8: 242. doi: 10.1186/1748-717X-8-242
  • Cengiz M, Ozyigit G, Yazici G, et al. Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent headand- neck tumors. Int J Radiat Oncol Biol Phys 2011;81:104- 9. doi: 10.1016/j.ijrobp.2010.04.027
There are 15 citations in total.

Details

Subjects Clinical Sciences
Journal Section Case Reports
Authors

Bilgehan Sahın This is me

Banu Atalar This is me

Abdullah Yakupoglu This is me

Enis Ozyar This is me

Publication Date May 14, 2017
Published in Issue Year 2017

Cite

APA Sahın, B., Atalar, B., Yakupoglu, A., Ozyar, E. (2017). Carotid blowout syndrome after intensity-modulated radiation therapy: A case report. Marmara Medical Journal, 30(2), 124-129. https://doi.org/10.5472/marumj.344828
AMA Sahın B, Atalar B, Yakupoglu A, Ozyar E. Carotid blowout syndrome after intensity-modulated radiation therapy: A case report. Marmara Med J. May 2017;30(2):124-129. doi:10.5472/marumj.344828
Chicago Sahın, Bilgehan, Banu Atalar, Abdullah Yakupoglu, and Enis Ozyar. “Carotid Blowout Syndrome After Intensity-Modulated Radiation Therapy: A Case Report”. Marmara Medical Journal 30, no. 2 (May 2017): 124-29. https://doi.org/10.5472/marumj.344828.
EndNote Sahın B, Atalar B, Yakupoglu A, Ozyar E (May 1, 2017) Carotid blowout syndrome after intensity-modulated radiation therapy: A case report. Marmara Medical Journal 30 2 124–129.
IEEE B. Sahın, B. Atalar, A. Yakupoglu, and E. Ozyar, “Carotid blowout syndrome after intensity-modulated radiation therapy: A case report”, Marmara Med J, vol. 30, no. 2, pp. 124–129, 2017, doi: 10.5472/marumj.344828.
ISNAD Sahın, Bilgehan et al. “Carotid Blowout Syndrome After Intensity-Modulated Radiation Therapy: A Case Report”. Marmara Medical Journal 30/2 (May 2017), 124-129. https://doi.org/10.5472/marumj.344828.
JAMA Sahın B, Atalar B, Yakupoglu A, Ozyar E. Carotid blowout syndrome after intensity-modulated radiation therapy: A case report. Marmara Med J. 2017;30:124–129.
MLA Sahın, Bilgehan et al. “Carotid Blowout Syndrome After Intensity-Modulated Radiation Therapy: A Case Report”. Marmara Medical Journal, vol. 30, no. 2, 2017, pp. 124-9, doi:10.5472/marumj.344828.
Vancouver Sahın B, Atalar B, Yakupoglu A, Ozyar E. Carotid blowout syndrome after intensity-modulated radiation therapy: A case report. Marmara Med J. 2017;30(2):124-9.